Cited by 209T-cell and B-cell ImmunologyLiver physiology and pathologyTransplantation: Methods and Outcomes

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Antigen-Specific Primary Activation of CD8+ T Cells Within the Liver

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Bertolino, Patrick, Bowen, David G, McCaughan, Geoffrey W, Fazekas de St. Groth, Barbara·2001·The Journal of Immunology

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Abstract

It is generally accepted that naive T cells recirculate via the blood and lymph, but do not enter nonlymphoid tissues without prior activation and differentiation. In this study, we demonstrate that the liver is an exception to this rule. Naive Des-TCR transgenic CD8+ T cells specific for H-2Kb were selectively retained in the liver within a few minutes of adoptive transfer into transgenic Met-Kb mice expressing H-2Kb in the liver. Activated CD8+ cells were found in the liver, but not the blood, as soon as 2 h after transfer and underwent cell division and started to recirculate within 24 h of transfer. In contrast, CD8+ cells activated in the lymph nodes remained sequestered at that site for 2 days before entering the blood. Our results therefore suggest that, in addition to its previously described role as a non Ag-specific activated T cell graveyard, the liver is involved in Ag-specific activation of naive recirculating CD8+ T cells. This particular property of the liver, combined with the previously demonstrated ability of hepatocytes to induce tolerance by means of premature CD8+ T cell death, may be a major mechanism contributing to the acceptance of liver allografts and the chronicity of viral hepatitis.

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Tolerance, Danger and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 5,107
Hepatitis B Virus Immunopathogenesis
Chisari, F. V., & Ferrari, C. I. (1995) · Annual Review of Immunology · doi:10.1146/annurev.iy.13.040195.000333 · Cited by 1,584
Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors.
Unkeless, J. C. (1979) · The Journal of Experimental Medicine · doi:10.1084/jem.150.3.580 · Cited by 1,271
Induction of Immunological Tolerance by Porcine Liver Allografts
Calne, R. Y., Sells, R. A., Peña, J., Davis, D., Millard, P. R., Herbertson, B. M., BINNS, R. M., & Davies, D. A. L. (1969) · Nature · doi:10.1038/223472a0 · Cited by 837
IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.
Sarmiento, M., Glasebrook, A. L., & Fitch, F. W. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.125.6.2665 · Cited by 816
Naive and memory T cells show distinct pathways of lymphocyte recirculation.
Mackay, C. R., Marston, W. L., & Dudler, L. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.3.801 · Cited by 787
Hepatology. A Textbook of Liver Disease
(1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-3-259_2 · Cited by 624
Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells
Ceredig, R. H., Lowenthal, J. W., Nabholz, M., & MacDonald, H. R. (1985) · Nature · doi:10.1038/314098a0 · Cited by 594
Pathology of the liver
MacSween, N. M. R. (1979) · Churchill Livingstone eBooks · Cited by 572
The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.
Metlay, J. P., Witmer-Pack, M. D., Agger, R., Crowley, M. T., Lawless, D., & Steinman, R. M. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.5.1753 · Cited by 555

Show all 47 references

Research works printed but not linked: 44

1990, J. Exp. Med., 801
1993, Adv. Immunol., 217
1994, J. Immunol., 482
1996, Immunol. Today, 522
2000, Hepatology, 1374
1995, Eur. J. Immunol., 1932
1969, Nature, 472
1981, Nature, 840
1994, Hepatology, 916
1994, Annu. Rev. Immunol., 991
1998, Eur. J. Immunol., 2395
1989, Proc. Natl. Acad. Sci. USA, 3782
1995, J. Immunol., 2339
1991, Cell, 293
1986, J. Immunol., 1927
1985, Nature, 98
1980, J. Immunol., 2665
1998, Eur. J. Immunol., 221
1999, J. Exp. Med., 593
1997, J. Immunol., 565
1990, J. Exp. Med., 1753
1988, J. Immunol., 369
1982, Immunogenetics, 299
1979, J. Exp. Med., 580
1996, Cytometry, 131
1994, Immunity, 741
1993, J. Exp. Med., 1807
1996, J. Exp. Med., 687
1996, Eur. J. Immunol., 3114
1999, J. Immunol., 3202
1999, Hepatology, 705
1998, J. Exp. Med., 1147
1994, Transgenics, 1
1992, Nature, 547
1999, Int. Immunol., 101
1999, Hepatology, 595
1997, J. Viral Hepatitis, 31
1997, J. Gastroenterol. Hepatol., S227
1995, Annu. Rev. Immunol., 29
1995, J. Virol., 2462
1995, J. Clin. Invest., 521
1996, J. Virol., 7092
2000, Immunol. Rev., 5
2000, Immunol. Rev., 77

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Polakos, N. K., Klein, I., Richter, M. V., Zaiss, D. M. W., Giannandrea, M., Crispe, I. N., & Topham, D. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.201 · Cited by 38
Characterization of the liver-draining lymph nodes in mice and their role in mounting regional immunity to HBV
Zheng, M., Yu, J., & Tian, Z. (2013) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.59 · Cited by 39
Antigen Export during Liver Infection of the Malaria Parasite Augments Protective Immunity
Montagna, G., Bompadre, M. B., Becker, M., Kroczek, R. A., Kaufmann, S. H. E., & Matuschewski, K. (2014) · mBio · doi:10.1128/mbio.01321-14 · Cited by 38
T‐cell migration: a naive paradigm?
Cose, S. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02511.x · Cited by 39
Immune response and tolerance during chronic hepatitis B virus infection
Bertoletti, A., & Gehring, A. J. (2007) · Hepatology Research · doi:10.1111/j.1872-034x.2007.00221.x · Cited by 36
Liver immunity, autoimmunity, and inborn errors of immunity
Parlar, Y. E., Ayar, Ş. N., Cağdaş, D. N., & Balaban, Y. H. (2023) · World Journal of Hepatology · doi:10.4254/wjh.v15.i1.52 · Cited by 36
Regulatory T-cell therapy in liver transplantation
Whitehouse, G. P., Hope, A. J., & Fueyo, A. S. (2017) · Transplant International · doi:10.1111/tri.12998 · Cited by 35
Red blood cells promote survival and cell cycle progression of human peripheral blood T cells independently of CD58/LFA-3 and heme compounds
Fonseca, A. M., Pereira, C., Porto, G., & Arosa, F. A. (2003) · Cellular Immunology · doi:10.1016/s0008-8749(03)00170-9 · Cited by 35
Role of T cells in liver metastasis
Wu, K., Zhang, G., Shen, C., Zhu, L., Yu, C., Sartorius, K., Ding, W., Jiang, Y., & Lu, Y. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06726-2 · Cited by 38
Tolerance in liver transplantation
Bishop, G. A., Bertolino, P., Bowen, D. G., & McCaughan, G. W. (2012) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2012.01.003 · Cited by 35
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Calzada‐Fraile, D., Iborra, S., Ramírez‐Huesca, M., Jorge, I., Dotta, E., Hernández‐García, E., Martin-Cofreces, N. B., Nistal‐Villán, E., Veiga, E., Vázquez, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42480-3 · Cited by 33
HBV-Specific Adaptive Immunity
Bertoletti, A., Tan, A. T., & Gehring, A. J. (2009) · Viruses · doi:10.3390/v1020091 · Cited by 34
Extranodal induction of therapeutic immunity in the tumor microenvironment after intratumoral delivery of Tbet gene-modified dendritic cells
Chen, L. C., Taylor, J. L., Chi-Sabins, N., Lowe, D. B., Qu, Y., You, Z., & Storkus, W. J. (2013) · Cancer Gene Therapy · doi:10.1038/cgt.2013.42 · Cited by 33
CD1d-Restricted pathways in hepatocytes control local natural killer T cell homeostasis and hepatic inflammation
Zeissig, S., Peuker, K., Iyer, S., Gensollen, T., Dougan, S., Olszak, T., Kaser, A., & Blumberg, R. (2017) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1701428114 · Cited by 29
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Wang, L. (2015) · World Journal of Hepatology · doi:10.4254/wjh.v7.i30.2980 · Cited by 31
Animal models of autoimmune liver disease
Peters, M. G. (2002) · Immunology and Cell Biology · doi:10.1046/j.0818-9641.2001.01059.x · Cited by 31
TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling
Kumar, S. R. P., Biswas, M., Cao, D., Arisa, S., Muñoz-Melero, M., Lam, A. K., Piñeros, A. R., Kapur, R., Kaisho, T., Kaufman, R. J., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2023.11.029 · Cited by 31
Memory CD8 T Cells Specific for Plasmodia Liver-Stage Antigens Maintain Protracted Protection Against Malaria
Krzych, U., Dalai, S. K., Zarling, S., & Pichugin, A. V. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00370 · Cited by 30
Influence of CD8 T cell priming in liver and gut on the enterohepatic circulation
Eickmeier, I., Seidel, D., Grün, J. R., Derkow, K., Lehnardt, S., Kühl, A. A., Hamann, A., & Schott, E. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.02.011 · Cited by 30
Alloantigen gene transfer to hepatocytes promotes tolerance to pancreatic islet graft by inducing CD8 + regulatory T cells
Guen, V. L., Judor, J., Boeffard, F., Gauttier, V., Ferry, N., Soulillou, J., Brouard, S., & Conchon, S. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.11.019 · Cited by 34
Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation
Tay, S. S., Lü, B., Sierro, F., Benseler, V., McGuffog, C., Bishop, A. G., Cowan, P. J., McCaughan, G. W., Dwyer, K. M., Bowen, D. G., et al. (2013) · Liver Transplantation · doi:10.1002/lt.23720 · Cited by 29
Self-citation
The role of hepatic immune regulation in systemic immunity to viral infection
Knolle, P. A., Böttcher, J. P., & Huang, L. (2014) · Medical Microbiology and Immunology · doi:10.1007/s00430-014-0371-0 · Cited by 29
Liver-resident memory T cells: life in lockdown
Pallett, L. J., & Maini, M. K. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00932-w · Cited by 28
Imbalance of Vaginal Microbiota and Immunity: Two Main Accomplices of Cervical Cancer in Chinese Women
Li, X., Wu, J., Wu, Y., Duan, Z., Luo, M., Li, L., Li, S., & Jia, Y. (2023) · International Journal of Women s Health · doi:10.2147/ijwh.s406596 · Cited by 28
Dendritic cell function and antigen presentation in malaria.
Cockburn, I., & Zavala, F. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.01.010 · Cited by 28
Vaginal type-II mucosa is an inductive site for primary CD8+ T-cell mucosal immunity
Wang, Y., Sui, Y., Kato, S., Hogg, A. E., Steel, J. C., Morris, J. C., & Berzofsky, J. A. (2015) · Nature Communications · doi:10.1038/ncomms7100 · Cited by 29

Authors: Bertolino, P., Bowen, D. G., McCaughan, G. W., & Fazekas de St. Groth, B.
Affiliations: Centenary Institute (AU)
Centenary Institute of Cancer Medicine and Cell Biology , Newtown ,
ORCID: Bertolino, Patrick
Bowen, David G
McCaughan, Geoffrey W
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2001-05-01
Volume: 166
Issue: 9
Pages: 5430-5438
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.166.9.5430
OpenAlex: W2141770821
Cited by: 209
References: 47
Citations by year: 2026: 3 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 8 · 2015: 10 · 2014: 11 · 2013: 15 · 2012: 8
FWCI: 2.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: University of Sydney
Medical Research Council
National Health and Medical Research Council
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
Keywords: CD8+ T cells, liver, antigen-specific T cell activation, H-2Kb, viral hepatitis, T cell division
MeSH terms: Animals, Antigens, Differentiation, T-Lymphocyte, Autoantigens, Cell Division, Cell Movement, H-2 Antigens, Interphase, Liver, Lymph Nodes, Lymphocyte Activation, Metallothionein, Mice, Inbred C57BL, Mice, Transgenic, Receptors, Antigen, T-Cell, Time Factors, Apoptosis, Lymphocyte Transfusion, CD8-Positive T-Lymphocytes, Epitopes, T-Lymphocyte, Adoptive Transfer, Mice

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Antigen-Specific Primary Activation of CD8+ T Cells Within the Liver

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