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Cited by 608T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

Tissue-Resident T Cells and Other Resident Leukocytes

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Masopust, David, Soerens, Andrew G.·2019·Annual Review of Immunology
DOI 10.1146/annurev-immunol-042617-053214PMC PMC7175802
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Abstract

Resident memory T (Trm) cells stably occupy tissues and cannot be sampled in superficial venous blood. Trm cells are heterogeneous but collectively constitute the most abundant memory T cell subset. Trm cells form an integral part of the immune sensing network, monitor for local perturbations in homeostasis throughout the body, participate in protection from infection and cancer, and likely promote autoimmunity, allergy, and inflammatory diseases and impede successful transplantation. Thus Trm cells are major candidates for therapeutic manipulation. Here we review CD8 + and CD4 + Trm ontogeny, maintenance, function, and distribution within lymphoid and nonlymphoid tissues and strategies for their study. We briefly discuss other resident leukocyte populations, including innate lymphoid cells, macrophages, natural killer and natural killer T cells, nonclassical T cells, and memory B cells. Lastly, we highlight major gaps in knowledge and propose ways in which a deeper understanding could result in new methods to prevent or treat diverse human diseases.

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  • TRM cells can be distinguished from effector memory T cells by downregulation of S1PR1 and upregulation of tissue retention molecules like CD103 and CD69.

    “T RM cells can be distinguished from effector memory T cells by their downregulation of tissue egress protein S1PR1 (sphingosine 1-phosphate receptor) and upregulation of tissue retention molecules like CD103 and CD69. 292-294”

    From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [293]

    The Resident Memory T Cell Maintenance section says TRM cells lack surface S1PR1 and describes CD69 as an antagonist of S1PR1. The Tools for Identifying Resident Memory T Cells section says most TRM cells express CD69 and many CD8 TRM cells express CD103, supporting a typical phenotypic distinction. But it cautions that most TRM cells likely lack CD103, some lack CD69, and recirculating T cells can express CD69; these markers cannot reliably distinguish every TRM cell from recirculating memory cells. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Masopust, D., & Soerens, A. G.
Affiliations
University of Minnesota (US)
ORCID
Venue
Annual Review of Immunology
Publisher
Annual Reviews
Published
2019-04-26
Volume
37
Issue
1
Pages
521-546
ISSN
  • 0732-0582 (ISSN-L)
  • 1545-3278
DOI
10.1146/annurev-immunol-042617-053214
PMC
PMC7175802
OpenAlex
W2914668666
Cited by
608
References
13
Citations by year
2026: 56 · 2025: 84 · 2024: 81 · 2023: 81 · 2022: 93 · 2021: 97 · 2020: 81 · 2019: 35
FWCI
6.68
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (T32HL007741)
  • National Institute of Allergy and Infectious Diseases (R01AI084913, R01AI111671, R01AI146032, R37AI084913)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
tissue-resident memory T cells, CD8+ T cells, CD4+ T cells, innate lymphoid cells, macrophages, natural killer cells, NKT cells, memory B cells, immune surveillance, autoimmunity, transplantation tolerance, immunotherapy
MeSH terms
Animals, B-Lymphocytes, Cell Movement, Humans, Immunity, Innate, Immunologic Memory, Killer Cells, Natural, Leukocytes, Macrophages, Organ Specificity, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes

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