The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
IFN-γ Overproduction and High Level Apoptosis Are Associated with High but Not Low Virulence Toxoplasma gondii Infection
Open accessAbstract
Toxoplasma gondii is an opportunistic intracellular parasite which induces a highly strong type 1 cytokine response. The present study focuses on defining the factors influencing the outcome of infection with tachyzoites of the type I, highly lethal RH strain, relative to the type II, low virulence strain ME49. Infection with the RH strain led to widespread parasite dissemination and rapid death of mice; in contrast, mice survived low virulence strain ME49 infection, and tachyzoite dissemination was much less extensive. Furthermore, massive apoptosis and disintegration of the splenic architecture was characteristic of RH, but not ME49, infection. In addition, hyperinduction of IFN-γ and lack of NO production were found during RH, in contrast to ME49 infection. These data demonstrate that Toxoplasma strain characteristics exert a profound effect on the host immune response and that the latter itself is a crucial determinant in parasite virulence.
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Cites
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287
Cited by
Pyroptotic cell death defends against intracellular pathogens
Jorgensen, I., & Miao, E. A. (2015) · Immunological Reviews · doi:10.1111/imr.12287 · Cited by 1,021
Acute Toxoplasmosis Leads to Lethal Overproduction of Th1 Cytokines
Mordue, D. G., Monroy, F., La Regina, M., Dinarello, C. A., & Sibley, L. D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.8.4574 · Cited by 396
Saeij, J. P. J., Boyle, J. P., & Boothroyd, J. C. (2005) · Trends in Parasitology · doi:10.1016/j.pt.2005.08.001 · Cited by 351
Toxoplasma Effectors Targeting Host Signaling and Transcription
Hakimi, M.-A., Olias, P., & Sibley, L. D. (2017) · Clinical Microbiology Reviews · doi:10.1128/cmr.00005-17 · Cited by 339
Alternatively activated macrophages during parasite infections
Noël, W. (2004) · Trends in Parasitology · doi:10.1016/j.pt.2004.01.004 · Cited by 301
Metadata
- Authors
- Gavrilescu, L. C., & Denkers, E. Y.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-07
- Volume
- 167
- Issue
- 2
- Pages
- 902-909
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2138814634
- Cited by
- 179
- References
- 1
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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