Pyroptotic cell death defends against intracellular pathogens
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Summary: Inflammatory caspases play a central role in innate immunity by responding to cytosolic signals and initiating a twofold response. First, caspase‐1 induces the activation and secretion of the two prominent pro‐inflammatory cytokines, interleukin‐1β ( IL ‐1β) and IL ‐18. Second, either caspase‐1 or caspase‐11 can trigger a form of lytic, programmed cell death called pyroptosis. Pyroptosis operates to remove the replication niche of intracellular pathogens, making them susceptible to phagocytosis and killing by a secondary phagocyte. However, aberrant, systemic activation of pyroptosis in vivo may contribute to sepsis. Emphasizing the efficiency of inflammasome detection of microbial infections, many pathogens have evolved to avoid or subvert pyroptosis. This review focuses on molecular and morphological characteristics of pyroptosis and the individual inflammasomes and their contribution to defense against infection in mice and humans.
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Pyroptosis manifests with a peculiar form of chromatin condensation that differs from apoptosis, and cellular swelling culminating with plasma membrane permeabilization.
“These include a peculiar form of chromatin condensation that differs from its apoptotic counterpart, as well as cellular swelling culminating with plasma membrane permeabilization [602].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [602]
Pyroptosis has a major role in innate immunity against intracellular pathogens.
“(3) has a major role in innate immunity against intracellular pathogens [602]”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [602]
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“A newly identified PRR, first described in detail in 2002, is the inflammasome (Martinon et al., 2002; Gentile et al., 2015; Jorgensen and Miao, 2015; Sanders et al., 2015).”
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- Authors
- Jorgensen, I., & Miao, E. A.
- Affiliations
- Department of Microbiology and Immunology Center for Gastrointestinal Biology and Disease University of North Carolina at Chapel Hill Chapel Hill NC USA
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Miao, Edward A.
- ORCID
- Miao, Edward A.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2015-04-16
- Volume
- 265
- Issue
- 1
- Pages
- 130-142
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC4400865
- OpenAlex
- W2003605139
- Cited by
- 1,021
- References
- 125
- Citations by year
- 2026: 47 · 2025: 79 · 2024: 115 · 2023: 127 · 2022: 169 · 2021: 125 · 2020: 103 · 2019: 86 · 2018: 57 · 2017: 51 · 2016: 47 · 2015: 15
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (DK007737, AI097518)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- pyroptosis, inflammatory caspases, caspase-1, caspase-11, inflammasome, IL-1β, IL-18, innate immunity, intracellular pathogens, sepsis, phagocytosis, innate immune defense
- MeSH terms
- Pyroptosis, Animals, DNA Replication, Humans, Immunity, Innate, Infections, Interleukin-1, Caspases, Caspase 1, Interleukin-18, Intracellular Space, Mice, Caspases, Initiator, Immune Evasion, Inflammasomes
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