The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Critical Role for IL-13 in the Development of Allergen-Induced Airway Hyperreactivity
Open accessAbstract
Airway hyperresponsiveness to a variety of specific and nonspecific stimuli is a cardinal feature of asthma, which affects nearly 10% of the population in industrialized countries. Eosinophilic pulmonary inflammation, eosinophil-derived products, as well as Th2 cytokines IL-13, IL-4, and IL-5, have been associated with the development of airway hyperreactivity (AHR), but the specific immunological basis underlying the development of AHR remains controversial. Herein we show that mice with targeted deletion of IL-13 failed to develop allergen-induced AHR, despite the presence of vigorous Th2-biased, eosinophilic pulmonary inflammation. However, AHR was restored in IL-13−/− mice by the administration of recombinant IL-13. Moreover, adoptive transfer of OVA-specific Th2 cells generated from TCR-transgenic IL-13−/− mice failed to induce AHR in recipient SCID mice, although such IL-13−/− Th2 cells produced high levels of IL-4 and IL-5 and induced significant airway inflammation. These studies definitively demonstrate that IL-13 is necessary and sufficient for the induction of AHR and that eosinophilic airway inflammation in the absence of IL-13 is inadequate for the induction of AHR. Therefore, treatment of human asthma with antagonists of IL-13 may be very effective.
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Cites
Interleukin-13: Central Mediator of Allergic Asthma
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NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway
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Self-citationFibrotic disease and the TH1/TH2 paradigm
Wynn, T. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1412 · Cited by 1,765
Targeting key proximal drivers of type 2 inflammation in disease
Gandhi, N. A., Bennett, B. L., Graham, N. M. H., Pirozzi, G., Stahl, N., & Yancopoulos, G. D. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd4624 · Cited by 766
Interleukin‐13 in asthma pathogenesis
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Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
Rangasamy, T., Guo, J., Mitzner, W. A., Roman, J., Singh, A., Fryer, A. D., Yamamoto, M., Kensler, T. W., Tuder, R. M., Georas, S. N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050538 · Cited by 580
Metadata
- Authors
- Walter, D. M., McIntire, J. J., Berry, G., McKenzie, A. N. J., Donaldson, D. D., DeKruyff, R. H., & Umetsu, D. T.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-10
- Volume
- 167
- Issue
- 8
- Pages
- 4668-4675
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2165933222
- Cited by
- 396
- References
- 45
- FWCI
- 14.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Walter, D. M., McIntire, J. J., Berry, G., McKenzie, A. N. J., Donaldson, D. D., DeKruyff, R. H., & Umetsu, D. T. (2001). Critical Role for IL-13 in the Development of Allergen-Induced Airway Hyperreactivity. The Journal of Immunology. https://doi.org/10.4049/jimmunol.167.8.4668
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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