The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses
Open accessAbstract
Specific and selective immunological unresponsiveness to donor alloantigens can be induced in vivo. We have shown previously that CD25+CD4+ T cells from mice exhibiting long-term operational tolerance to donor alloantigens can regulate rejection of allogeneic skin grafts mediated by CD45RBhighCD4+ T cells. In this study, we wished to determine whether donor-specific regulatory cells can be generated during the induction phase of unresponsiveness, i.e., before transplantation. We provide evidence that pretreatment with anti-CD4 Ab plus a donor-specific transfusion generates donor-specific regulatory CD25+CD4+ T cells that can suppress rejection of skin grafts mediated by naive CD45RBhighCD4+ T cells. Regulatory cells were contained only in the CD25+ fraction, as equivalent numbers of CD25−CD4+ T cells were unable to regulate rejection. This pretreatment strategy led to increased expression of CD122 by the CD25+CD4+ T cells. Blockade of both the IL-10 and CTLA-4 pathways abrogated immunoregulation mediated by CD25+ T cells, suggesting that IL-10 and CTLA-4 are required for the functional activity of this population of immunoregulatory T cells. In clinical transplantation, the generation of regulatory T cells that could provide dynamic control of rejection responses is a possible route to permanent graft survival without the need for long-term immunosuppression.
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Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4
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Molecular Basis of T Cell Inactivation by CTLA-4
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Regulation of Cytotoxic T Lymphocyte-Associated Molecule-4 by Src Kinases
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“These include recruitment of the phosphatase SHP-2 into the immunological synapse (48, 49) and the secretion of the immunoregulatory cytokine TGF- (50).”
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Cited by
Schwartz, R. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141110 · Cited by 1,487
Modulation of tryptophan catabolism by regulatory T cells
Fallarino, F., Grohmann, U., Hwang, K. W., Orabona, C., Vacca, C., Bianchi, R., Belladonna, M. L., Fioretti, M. C., Alegre, M.-L., & Puccetti, P. (2003) · Nature Immunology · doi:10.1038/ni1003 · Cited by 1,374
Regulatory T cells in transplantation tolerance
Wood, K. J., & Sakaguchi, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri1027 · Cited by 1,317
Self-citationHuman T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death
Grossman, W. J., Verbsky, J. W., Barchet, W., Colonna, M., Atkinson, J. P., & Ley, T. J. (2004) · Immunity · doi:10.1016/j.immuni.2004.09.002 · Cited by 1,020
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
Tang, Q., Adams, J. Y., Tooley, A. J., Bi, M., Fife, B. T., Serra, P., Santamaria, P., Locksley, R. M., Krummel, M. F., & Bluestone, J. A. (2006) · Nature Immunology · doi:10.1038/ni1289 · Cited by 774
Metadata
- Authors
- Kingsley, C. I., Karim, M., Bushell, A. R., & Wood, K. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-02-01
- Volume
- 168
- Issue
- 3
- Pages
- 1080-1086
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2114412297
- Cited by
- 743
- References
- 5
- FWCI
- 21.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses. https://app.cochat.ai/papers/10.4049/jimmunol.168.3.1080
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- Kingsley, C. I., Karim, M., Bushell, A. R., & Wood, K. J. (2002). CD25+CD4+ Regulatory T Cells Prevent Graft Rejection: CTLA-4- and IL-10-Dependent Immunoregulation of Alloresponses. The Journal of Immunology. https://doi.org/10.4049/jimmunol.168.3.1080
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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