The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Temporal Segregation of 4-1BB Versus CD28-Mediated Costimulation: 4-1BB Ligand Influences T Cell Numbers Late in the Primary Response and Regulates the Size of the T Cell Memory Response Following Influenza Infection
Abstract
In this report, we demonstrate that CD28−/− mice are severely impaired in the initial expansion of Db/NP366-374-specific CD8 T cells in response to influenza virus infection, whereas 4-1BB ligand (4-1BBL)−/− mice show no defect in primary T cell expansion to influenza virus. In contrast, 4-1BBL−/− mice show a decrease in Db/NP366-374-specific T cells late in the primary response. Upon secondary challenge with influenza virus, 4-1BBL−/− mice show a decrease in the number of Db/NP366-374-specific T cells compared to wild-type mice such that the level of the CD8 T cell expansion during the in vivo secondary response is reduced to the level of a primary response, with concomitant reduction of CTL effector function. In contrast, Ab responses, as well as secondary CD4 T cell responses, to influenza are unaffected by 4-1BBL deficiency. Thus, CD28 is critical for initial T cell expansion, whereas 4-1BB/4-1BBL signaling affects T cell numbers much later in the response and is essential for the survival and/or responsiveness of the memory CD8 T cell pool.
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Cites
CD28/B7 SYSTEM OF T CELL COSTIMULATION
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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL
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CD27 is required for generation and long-term maintenance of T cell immunity
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Virus-Specific CD8+ T Cells in Primary and Secondary Influenza Pneumonia
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OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells
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Cited by
TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES
Watts, T. H. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115839 · Cited by 1,353
Self-citationSignals required for programming effector and memory development by CD8+ T cells
Mescher, M. F., Curtsinger, J. M., Agarwal, P., Casey, K. A., Gerner, M., Hammerbeck, C. D., Popescu, F., & Xiao, Z. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00382.x · Cited by 601
The B7 family member B7-H3 preferentially down-regulates T helper type 1–mediated immune responses
Suh, W.-K., Gajewska, B. U., Okada, H., Gronski, M. A., Bertram, E. M., Dawicki, W., Duncan, G. S., Bukczynski, J., Plyte, S., Elia, A., et al. (2003) · Nature Immunology · doi:10.1038/ni967 · Cited by 576
Self-citationCD8 T Cell Responses to Infectious Pathogens
Wong, P., & Pamer, E. G. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141114 · Cited by 425
Nolte, M. A., Van Olffen, R. W., Van Gisbergen, K. P. J. M., & Van Lier, R. A. W. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00774.x · Cited by 305
Metadata
- Authors
- Bertram, E. M., Lau, P., & Watts, T. H.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-04
- Volume
- 168
- Issue
- 8
- Pages
- 3777-3785
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1605178114
- Cited by
- 265
- References
- 49
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Temporal Segregation of 4-1BB Versus CD28-Mediated Costimulation: 4-1BB Ligand Influences T Cell Numbers Late in the Primary Response and Regulates the Size of the T Cell Memory Response Following Influenza Infection. https://app.cochat.ai/papers/10.4049/jimmunol.168.8.3777
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- Bertram, E. M., Lau, P., & Watts, T. H. (2002). Temporal Segregation of 4-1BB Versus CD28-Mediated Costimulation: 4-1BB Ligand Influences T Cell Numbers Late in the Primary Response and Regulates the Size of the T Cell Memory Response Following Influenza Infection. The Journal of Immunology. https://doi.org/10.4049/jimmunol.168.8.3777
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