The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
Timing and tuning of CD27–CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology
Abstract
Summary: After binding its natural ligand cluster of differentiation 70 (CD70), CD27, a tumor necrosis factor receptor (TNFR)‐associated factor‐binding member of the TNFR family, regulates cellular activity in subsets of T, B, and natural killer cells as well as hematopoietic progenitor cells. In normal immune responses, CD27 signaling appears to be limited predominantly by the restricted expression of CD70, which is only transiently expressed by cells of the immune system upon activation. Studies performed in CD27‐deficient and CD70‐transgenic mice have defined a non‐redundant role of this receptor–ligand pair in shaping adaptive T‐cell responses. Moreover, adjuvant properties of CD70 have been exploited for the design of anti‐cancer vaccines. However, continuous CD27–CD70 interactions may cause immune dysregulation and immunopathology in conditions of chronic immune activation such as during persistent virus infection and autoimmune disease. We conclude that optimal tuning of CD27–CD70 interaction is crucial for the regulation of the cellular immune response. We provide a detailed comparison of costimulation through CD27 with its closely related family members 4‐1BB (CD137), CD30, herpes virus entry mediator, OX40 (CD134), and glucocorticoid‐induced TNFR family‐related gene, and we argue that these receptors do not have a unique function per se but that rather the timing, context, and intensity of these costimulatory signals determine the functional consequence of their activity.
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Cites
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Cited by
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Chen, L., & Flies, D. B. (2013) · Nature Reviews Immunology · doi:10.1038/nri3405 · Cited by 3,114
The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry
Dominguez-Sola, D., Victora, G. D., Ying, C. Y., Phan, R. T., Saito, M., Nussenzweig, M. C., & Dalla-Favera, R. (2012) · Nature Immunology · doi:10.1038/ni.2428 · Cited by 490
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Waugh, K. A., Araya, P., Pandey, A., Jordan, K. R., Smith, K. P., Granrath, R. E., Khanal, S., Butcher, E. T., Estrada, B. E., Rachubinski, A. L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.038 · Cited by 150
Wang, M., Liu, Y., Cheng, Y., Wei, Y., & Wei, X. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.12.002 · Cited by 66
Metadata
- Authors
- Nolte, M. A., Van Olffen, R. W., Van Gisbergen, K. P. J. M., & Van Lier, R. A. W.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2009-04-21
- Volume
- 229
- Issue
- 1
- Pages
- 216-231
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2098582760
- Cited by
- 305
- References
- 131
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nolte, M. A., Van Olffen, R. W., Van Gisbergen, K. P. J. M., & Van Lier, R. A. W. (2009). Timing and tuning of CD27–CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology. Immunological Reviews. https://doi.org/10.1111/j.1600-065x.2009.00774.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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