The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Inhibition of Endogenous TGF-β During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage Repair
Abstract
Osteoarthritis has as main characteristics the degradation of articular cartilage and the formation of new bone at the joint edges, so-called osteophytes. In this study enhanced expression of TGF-β1 and -β3 was detected in developing osteophytes and articular cartilage during murine experimental osteoarthritis. To determine the role of endogenous TGF-β on osteophyte formation and articular cartilage, TGF-β activity was blocked via a scavenging soluble TGF-β-RII. Our results clearly show that inhibition of endogenous TGF-β nearly completely prevented osteophyte formation. In contrast, treatment with recombinant soluble TGF-β-RII markedly enhanced articular cartilage proteoglycan loss and reduced the thickness of articular cartilage. In conclusion, we show for the first time that endogenous TGF-β is a crucial factor in the process of osteophyte formation and has an important function in protection against cartilage loss.
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Cites
TGF‐β Latency: Biological Significance and Mechanisms of Activation
Gleizes, P., Munger, J. S., Nunes, I., Harpel, J. G., Mazzieri, R., Noguera, I., & Rifkin, D. B. (1997) · STEM CELLS · doi:10.1002/stem.150190 · Cited by 266
Cited by
Goldring, S. R., & Goldring, M. B. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.148 · Cited by 896
Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis
Blom, A. B., van Lent, P. L. E. M., Holthuysen, A. E. M., van der Kraan, P. M., Roth, J., van Rooijen, N., & van den Berg, W. B. (2004) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2004.03.003 · Cited by 373
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Metadata
- Authors
- Scharstuhl, A., Glansbeek, H. L., van Beuningen, H. M., Vitters, E. L., van der Kraan, P. M., & van den Berg, W. B.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-07-01
- Volume
- 169
- Issue
- 1
- Pages
- 507-514
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2113905699
- Cited by
- 219
- References
- 1
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Inhibition of Endogenous TGF-β During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage Repair. https://app.cochat.ai/papers/10.4049/jimmunol.169.1.507
- The paper
- Scharstuhl, A., Glansbeek, H. L., van Beuningen, H. M., Vitters, E. L., van der Kraan, P. M., & van den Berg, W. B. (2002). Inhibition of Endogenous TGF-β During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage Repair. The Journal of Immunology. https://doi.org/10.4049/jimmunol.169.1.507
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
