TGF‐β Latency: Biological Significance and Mechanisms of Activation

Gleizes, Pierre‐Emmanuel; Munger, John S.; Nunes, Irene; Harpel, John G.; Mazzieri, Roberta; Noguera, Irene; Rifkin, Daniel B.

doi:10.1002/stem.150190

Cited by 266TGF-β signaling in diseasesLiver physiology and pathologyProtease and Inhibitor Mechanisms

TGF‐β Latency: Biological Significance and Mechanisms of Activation

Gleizes, Pierre‐Emmanuel, Munger, John S., Nunes, Irene, Harpel, John G., Mazzieri, Roberta, Noguera, Irene, Rifkin, Daniel B.·1997·STEM CELLS

DOI 10.1002/stem.150190

Open this paper in CoChat — free account

Abstract

Transforming growth factor (TGF-) beta is secreted as a latent complex in which the mature growth factor remains associated with its propeptide. In order to elicit a biological response, the cytokine must be released from the latent complex, a process termed latent TGF-beta activation or TGF-beta formation. Although latent TGF-beta activation is a critical step in the regulation of its activity, little is known about the molecular mechanisms that lead to the production of active TGF-beta. In this article, we present an overview of the data available on this topic, and we propose a tentative model for the mechanism of TGF-beta formation based upon the observations with different cell systems and on recent findings on the structure of the latent TGF-beta complex.

Integrity signals

Registry

Crossref · 10.1002/stem.150190

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Mice lacking the TGF-β1 isoform develop severe multi-organ inflammation and die by week 4.
“The importance of TGF-β in the immune system is highlighted by the fact that mice lacking the TGF-β1 isoform, which is predominant in cells of the immune system, develop severe multi-organ inflammation and die by week 4 (70).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [70]
Cleavage by the endoprotease furin, at the ER or in the extracellular environment, is required for activation of TGF-β.
“Cleavage by the endoprotease furin, which can happen at the ER or in the extracellular environment, is required for activation of this cytokine (70).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [70]

The Transforming Growth Factor-Beta Family
Massagué, J. (1990) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.06.110190.003121 · Cited by 3,041 · see citing works
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.
Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967 · see citing works
Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice
Dickson, M. C., Martin, J. S., Cousins, F. M., Kulkarni, A. B., Karlsson, S., & Akhurst, R. J. (1995) · Development · doi:10.1242/dev.121.6.1845 · Cited by 1,029 · see citing works
Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.
Lyons, R. M., Keski‐Oja, J., & Moses, H. L. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.106.5.1659 · Cited by 969 · see citing works
Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.
Sato, Y., & Rifkin, D. B. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.1.309 · Cited by 908 · see citing works
Self-citation
Transforming growth factor–β3 is required for secondary palate fusion
Proetzel, G., Pawlowski, S. A., Wiles, M. V., Yin, M., Boivin, G. P., Howles, P. N., Ding, J., Ferguson, M. W. J., & Doetschman, T. (1995) · Nature Genetics · doi:10.1038/ng1295-409 · Cited by 908 · see citing works
The Transforming Growth Factor-βs
Roberts, A. B., & Sporn, M. B. (1991) · Springer eBooks · doi:10.1007/978-1-4612-3210-0_8 · Cited by 869 · see citing works
An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.
Orlidge, A., Saunders, K. B., Smith, S. R., & D'Amore, P. A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.12.4544 · Cited by 756 · see citing works
The Transforming Growth Factor-βs
Roberts, A. B., & Sporn, M. B. (1990) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-49295-2_8 · Cited by 744 · see citing works
Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.
Lyons, R. M., Gentry, L. E., Purchio, A. F., & Moses, H. L. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.4.1361 · Cited by 737 · see citing works
Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.
Sanderson, N., Factor, V., Nagy, P., Kopp, J. B., Kondaiah, P., Wakefield, L. M., Roberts, A. B., Sporn, M. B., & Thorgeirsson, S. S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2572 · Cited by 671 · see citing works
Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.
Miyazono, K., Hellman, U., Wernstedt, C., & Heldin, C. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68800-3 · Cited by 637 · see citing works
Redox-mediated activation of latent transforming growth factor-beta 1
Barcellos‐Hoff, M. H., & Dix, T. A. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.9.8885242 · Cited by 580 · see citing works
Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.
Dennis, P. A., & Rifkin, D. B. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.2.580 · Cited by 519 · see citing works
Self-citation
A role of the latent TGF‐beta 1‐binding protein in the assembly and secretion of TGF‐beta 1.
Miyazono, K., Olofsson, A., Colosetti, P., & Heldin, C. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb08049.x · Cited by 509 · see citing works
Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]
Schultz‐Cherry, S. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.4.923 · Cited by 468 · see citing works
TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences
Kanzaki, T., Olofsson, A., Morén, A., Wernstedt, C., Hellman, U., Miyazono, K., Claesson, L., & Heldin, C. (1990) · Cell · doi:10.1016/0092-8674(90)90069-q · Cited by 446 · see citing works
Latent transforming growth factor-beta 1 associates to fibroblast extracellular matrix via latent TGF-beta binding protein
Taipale, J., Miyazono, K., Ch, H., & Keski‐Oja, J. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.1.171 · Cited by 445 · see citing works
Crystal Structure of Transforming Growth Factor-β2: an Unusual Fold for the Superfamily
Daopin, S., Piez, K. A., Ogawa, Y., & Davies, D. R. (1992) · Science · doi:10.1126/science.1631557 · Cited by 440 · see citing works
Transforming growth factor-beta activation in irradiated murine mammary gland.
Barcellos‐Hoff, M. H., Derynck, R., Tsang, M., & Weatherbee, J. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117045 · Cited by 428 · see citing works
Proliferation of Human Smooth Muscle Cells Promoted by Lipoprotein(a)
Grainger, D. J., Kirschenlohr, H. L., Metcalfe, J. C., Weissberg, P. L., Wade, D. P., & Lawn, R. M. (1993) · Science · doi:10.1126/science.8503012 · Cited by 407 · see citing works
Processing of Transforming Growth Factor β1 Precursor by Human Furin Convertase
Dubois, C. M., Laprise, M., Blanchette, F., Gentry, L. E., & Leduc, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10618 · Cited by 405 · see citing works
A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells
Borkowski, T. A., Letterio, J. J., Farr, A. G., & Udey, M. C. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.6.2417 · Cited by 402 · see citing works
Human Mast Cell Chymase and Leukocyte Elastase Release Latent Transforming Growth Factor-β1 from the Extracellular Matrix of Cultured Human Epithelial and Endothelial Cells
Taipale, J., Lohi, J., Saarinen, J., Kovanen, P. T., & Keski‐Oja, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4689 · Cited by 396 · see citing works
Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β
Nunes, I., Gleizes, P., Metz, C. N., & Rifkin, D. B. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.5.1151 · Cited by 395 · see citing works
Self-citation
Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions
Lawrence, D. A., Pircher, R., & Jullien, P. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)91239-2 · Cited by 365 · see citing works
Activation of transforming growth factor-β is inhibited in transgenic apolipoprotein(a) mice
Grainger, D. J., Kemp, P. R., Liu, A. C., Lawn, R. M., & Metcalfe, J. C. (1994) · Nature · doi:10.1038/370460a0 · Cited by 352 · see citing works
Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3
Brownh, P. D., Wakefield, L. M., Levinson, A. D., & Sporn, M. B. (1990) · Growth Factors · doi:10.3109/08977199009037500 · Cited by 346 · see citing works
An unusual feature revealed by the crystal structure at 2.2 Å resolution of human transforming growth fact or-β2
Schlunegger, M. P., & Grütter, M. G. (1992) · Nature · doi:10.1038/358430a0 · Cited by 336 · see citing works
Activation of the bone-derived latent TGF beta complex by isolated osteoclasts
Oreffo, R. O. C., Mundy, G. R., Seyedin, S. M., & Bonewald, L. F. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92795-2 · Cited by 285 · see citing works
Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells.
Kojima, S., Nara, K., & Rifkin, D. B. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.2.439 · Cited by 283 · see citing works
Self-citation
Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.
Diebold, R. J., Eis, M. J., Yin, M., Ormsby, I., Boivin, G. P., Darrow, B. J., Saffitz, J. E., & Doetschman, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12215 · Cited by 278 · see citing works
Role for carbohydrate structures inTGF-β1 latency
Miyazono, K., & Heldin, C. (1989) · Nature · doi:10.1038/338158a0 · Cited by 265 · see citing works
Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1.Preprint
Pierce, D. F., Johnson, M. D., Matsui, Y., Robinson, S. D., Gold, L. I., Purchio, A. F., Daniel, C. W., Hogan, B. L. M., & Moses, H. L. (1993) · Genes & Development · doi:10.1101/gad.7.12a.2308 · Cited by 264 · see citing works
Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein.
Dallas, S. L., Miyazono, K., Skerry, T. M., Mundy, G. R., & Bonewald, L. F. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.2.539 · Cited by 263 · see citing works
Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.
Sellheyer, K., Bickenbach, J. R., Rothnagel, J. A., Bundman, D. S., Longley, M. A., Krieg, T. M., Roche, N. S., Roberts, A. B., & Roop, D. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5237 · Cited by 254 · see citing works
The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.
Schultz‐Cherry, S., Lawler, J., & Murphy-Ullrich, J. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47087-1 · Cited by 252 · see citing works
Influenza virus neuraminidase activates latent transforming growth factor beta
Schultz‐Cherry, S., & Hinshaw, V. S. (1996) · Journal of Virology · doi:10.1128/jvi.70.12.8624-8629.1996 · Cited by 246 · see citing works
Association of the small latent transforming growth factor‐beta with an eight cysteine repeat of its binding protein LTBP‐1.
Saharinen, J., Taipale, J., & Keski‐Oja, J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00355.x · Cited by 240 · see citing works
Role of the latent TGF-beta binding protein in the activation of latent TGF-beta by co-cultures of endothelial and smooth muscle cells.
Flaumenhaft, R. C., Abé, M., Sato, Y., Miyazono, K., Harpel, J. G., Heldin, C., & Rifkin, D. B. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.4.995 · Cited by 236 · see citing works
Self-citation
Lipoprotein (a) inhibits the generation of transforming growth factor beta: an endogenous inhibitor of smooth muscle cell migration.
Kojima, S., Harpel, P. C., & Rifkin, D. B. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.113.6.1439 · Cited by 231 · see citing works
Self-citation
Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils.
Taipale, J., Saharinen, J., Hedman, K., & Keski‐Oja, J. (1996) · Journal of Histochemistry & Cytochemistry · doi:10.1177/44.8.8756760 · Cited by 224 · see citing works
Arrested Lung Morphogenesis in Transgenic Mice Bearing an SP-C–TGF-β1 Chimeric Gene
Zhou, L., Dey, C. R., Wert, S. E., & Whitsett, J. A. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0110 · Cited by 223 · see citing works
Identification of mannose 6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor-beta 1 precursor.
Purchio, A. F., Cooper, J. A., Brunner, A. M., Lioubin, M. N., Gentry, L. E., Kovacina, K. S., Roth, R. A., & Marquardt, H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68207-9 · Cited by 207 · see citing works
Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity.
Flaumenhaft, R. C., Abé, M., Mignatti, P., & Rifkin, D. B. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.4.901 · Cited by 201 · see citing works
Self-citation
Identification and characterization of LTBP-2, a novel latent transforming growth factor-beta-binding protein.
Morén, A., Olofsson, A., Stenman, G., Sahlin, P., Kanzaki, T., Claesson, L., ten Dijke, P., Miyazono, K., & Heldin, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31659-4 · Cited by 190 · see citing works
Bovine Latent Transforming Growth Factor β1-Binding Protein 2: Molecular Cloning, Identification of Tissue Isoforms, and Immunolocalization to Elastin-Associated Microfibrils
Gibson, M. A., Hatzinikolas, G., Davis, E. C., Baker, E., Sutherland, G. R., & Mecham, R. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.6932 · Cited by 187 · see citing works
The pro domain of pre-pro-transforming growth factor .beta.1 when independently expressed is a functional binding protein for the mature growth factor
Gentry, L. E., & Nash, B. W. (1990) · Biochemistry · doi:10.1021/bi00481a014 · Cited by 184 · see citing works
Characterization of latent TGF-β activation by murine peritoneal macrophages
Nunes, I., Shapiro, R. L., & Rifkin, D. B. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1450 · Cited by 176 · see citing works
Self-citation
Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein.
Dallas, S. L., Park-Snyder, S., Miyazono, K., Twardzik, D. R., Mundy, G. R., & Bonewald, L. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37449-5 · Cited by 171 · see citing works
Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues.
Tsuji, T., Okada, F., Yamaguchi, K., & Nakamura, T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.22.8835 · Cited by 161 · see citing works
Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma.Preprint
Glick, A. B., Lee, M., Darwiche, N., Kulkarni, A. B., Karlsson, S., & Yuspa, S. H. (1994) · Genes & Development · doi:10.1101/gad.8.20.2429 · Cited by 157 · see citing works
Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor beta 1.
Arrick, B. A., Lopez, A. R., Elfman, F., Ebner, R., Damsky, C. H., & Derynck, R. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.3.715 · Cited by 157 · see citing works
Latent high molecular weight complex of transforming growth factor. beta. 1
Miyazono, K., Hellman, U., Wernstedt, C., & Heldin, C. H. (1988) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · Cited by 146 · see citing works
Identification and Characterization of an Eight-cysteine Repeat of the Latent Transforming Growth Factor-β Binding Protein-1 that Mediates Bonding to the Latent Transforming Growth Factor-β1
Gleizes, P., Beavis, R. C., Mazzieri, R., Shen, B., & Rifkin, D. B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.29891 · Cited by 145 · see citing works
Self-citation
Isolation of a Novel Latent Transforming Growth Factor-β Binding Protein Gene (LTBP-3)
Yin, W., Smiley, E. C., Germiller, J. A., Mecham, R. P., Florer, J. B., WENSTRUP, R. J., & Bonadio, J. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.10147 · Cited by 142 · see citing works
The control of hematopoiesis and leukemia: from basic biology to the clinic.
Sachs, L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4742 · Cited by 136 · see citing works
Insulinlike growth factor—ii/mannose 6-phosphate receptor is expressed on ccl4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-β in cocultures with sinusoidal endothelial cells
Bleserc, P. J. D., Jannes, P., van Buul-Offers, S. C., Hoogerbrugge, C. M., Schravendijk, C. F. H. V., Niki, T., Rogiers, V., den Brande, J. L. V., Wisse, E., & Geerts, A. E. (1995) · Hepatology · doi:10.1002/hep.1840210529 · Cited by 119 · see citing works
Mechanism of retinoid‐induced activation of latent transforming growth factor‐β in bovine endothelial cells
Kojima, S., & Rifkin, D. B. (1993) · Journal of Cellular Physiology · doi:10.1002/jcp.1041550213 · Cited by 114 · see citing works
Self-citation
Glucocorticoid-induced activation of latent transforming growth factor- beta by normal human osteoblast-like cells
Oursler, M. J., Riggs, B. L., & Spelsberg, T. C. (1993) · Endocrinology · doi:10.1210/endo.133.5.8404670 · Cited by 111 · see citing works
Overexpression of TGF-β1 in the Central Nervous System of Transgenic Mice Results in Hydrocephalus
Galbreath, E. J., Kim, S., Park, K., Brenner, M., & Messing, A. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199505000-00007 · Cited by 111 · see citing works
Efficient Association of an Amino-terminally Extended Form of Human Latent Transforming Growth Factor-β Binding Protein with the Extracellular Matrix
Olofsson, A., Ichijo, H., Morén, A., ten Dijke, P., Miyazono, K., & Heldin, C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.52.31294 · Cited by 85 · see citing works
Structural characterization of the latent complex between transforming growth factor β1 and β1-latency-associated peptide
McMahon, G. A., Dignam, J. D., & Gentry, L. E. (1996) · Biochemical Journal · doi:10.1042/bj3130343 · Cited by 77 · see citing works
Identification and activation of latent transforming growth factor β
Lawrence, D. A. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)98033-3 · Cited by 73 · see citing works
Feedback Mechanism of Focal Vascular Lesion Formation in Transgenic Apolipoprotein(a) Mice
Lawn, R. M., Pearle, A. D., Kunz, L. L., Rubin, E. M., Reckless, J., Metcalfe, J. C., & Grainger, D. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31367 · Cited by 55 · see citing works
Structure and activation of the large latent transforming growth factor-beta complex.
Nunes, I., Munger, J. S., Harpel, J. G., Nagano, Y., Rl, S., Gleizes, P., & Db, R. (1996) · PubMed · Cited by 48 · see citing works
Self-citation
Role of Transforming Growth Factor Beta in Bone Remodeling: A Review
Bonewald, L. F., & Mundy, G. R. (1989) · Connective Tissue Research · doi:10.3109/03008208909002418 · Cited by 46 · see citing works
Mediation of glucocorticoid receptor function by the activation of latent transforming growth factor beta 1 in MG‐63 human osteosarcoma cells
Boulanger, J., Reyes‐Moreno, C., & Koutsilieris, M. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910610517 · Cited by 44 · see citing works
Thrombospondins selectively activate one of the two latent forms of transforming growth factor-beta present in adrenocortical cell-conditioned medium.
Souchelnitskiy, S., CHAMBAZ, E. M., & Feige, J. (1995) · Endocrinology · doi:10.1210/endo.136.11.7588249 · Cited by 41 · see citing works
Effects of endogenously activated transforming growth factor-beta on growth and differentiation of retinoic acid-treated HL-60 cells.
Nunes, I., Kojima, S., & Rifkin, D. B. (1996) · PubMed · Cited by 41 · see citing works
Self-citation
Cloning and Overexpression of TGF-β1 cDNA in a Mammary Adenocarcinoma: In Vitro and In Vivo Effects
Theodorescu, D., Bergsma, D. J., Man, M. S., Elshourbagy, N. A., Sheehan, C., Rieman, D. J., & Kerbel, R. S. (1991) · Growth Factors · doi:10.3109/08977199109000294 · Cited by 15 · see citing works
Active transforming growth factor-β in human melanoma cell lines: No evidence for plasmin-related activation of latent TGF-β
Bízik, J., Felnerova, D., Grofova, M., & Vaheri, A. I. (1996) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(199607)62:1 · Cited by 10 · see citing works

Flagged first, then by citations

Sorted by citations

Macrophage Cytokines: Involvement in Immunity and Infectious Diseases
Arango Duque, G., & Descoteaux, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00491 · Cited by 2,708 · see citing works
“Cleavage by the endoprotease furin, which can happen at the ER or in the extracellular environment, is required for activation of this cytokine (70).”
Background
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation.
Huynh, M.-L. N., Fadok, V., & Henson, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci11638 · Cited by 1,333 · see citing works
Targeting TGF-β signal transduction for fibrosis and cancer therapy
Peng, D., Fu, M., Wang, M., Wei, Y., & Wei, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01569-x · Cited by 1,106 · see citing works
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation
Huynh, M.-L. N., Fadok, V. A., & Henson, P. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0211638 · Cited by 957 · see citing works
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs
Henderson, N. C., Arnold, T. D., Katamura, Y., Giacomini, M. M., Rodriguez, J. D., McCarty, J. H., Pellicoro, A., Raschperger, E., Betsholtz, C., Ruminski, P. G., et al. (2013) · Nature Medicine · doi:10.1038/nm.3282 · Cited by 866 · see citing works
TGF-β Activation and Function in Immunity
Travis, M. A., & Sheppard, D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120257 · Cited by 856 · see citing works
GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3 + regulatory T cells
Tran, D. Q., Andersson, J., Wang, R., Ramsey, H. E., Unutmaz, D., & Shevach, E. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901944106 · Cited by 473 · see citing works
The Myostatin Propeptide and the Follistatin-related Gene Are Inhibitory Binding Proteins of Myostatin in Normal Serum
Hill, J. J., Davies, M. V., Pearson, A. A., Wang, J. H., Hewick, R. M., Wolfman, N. M., & Qiu, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206379200 · Cited by 444 · see citing works
Activation of hepatic stellate cells - a key issue in liver fibrosis
Reeves, H. L. (2002) · Frontiers in bioscience · doi:10.2741/reeves · Cited by 420 · see citing works
The Role of IL-10 and TGF-β in the Differentiation and Effector Function of T Regulatory Cells
Levings, M. K., Bacchetta, R., Schulz, U., & Roncarolo, M. G. (2002) · International Archives of Allergy and Immunology · doi:10.1159/000067596 · Cited by 423 · see citing works
Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation
Horan, G. S., Wood, S., Ona, V., Li, D. J., Lukashev, M. E., Weinreb, P. H., Simon, K. J., Hahm, K., Allaire, N. E., Rinaldi, N. J., et al. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200706-805oc · Cited by 420 · see citing works
The aryl hydrocarbon receptor: studies using the AHR-null mice.
Gonzalez, F. J., & Fernández‐Salguero, P. M. (1998) · PubMed · Cited by 375 · see citing works
Cell Biology of Cardiac Cushion Development
Person, A. D., Klewer, S. E., & Runyan, R. B. (2005) · International review of cytology · doi:10.1016/s0074-7696(05)43005-3 · Cited by 369 · see citing works
Transforming growth factor-β: pleiotropic role in the regulation of hematopoiesis
Fortunel, N. O., Hatzfeld, A., & Hatzfeld, J. (2000) · Blood · doi:10.1182/blood.v96.6.2022.h8002022_2022_2036 · Cited by 314 · see citing works
Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1
Zhuang, X., Zhang, H., Li, X., Li, X., Cong, M., Peng, F., Yu, J., Zhang, X., Yang, Q., & Hu, G. (2017) · Nature Cell Biology · doi:10.1038/ncb3613 · Cited by 309 · see citing works
Circulating Transforming Growth Factor-β in Marfan Syndrome
Matt, P., Schoenhoff, F., Habashi, J. P., Holm, T. M., van Erp, C., Loch, D. C., Carlson, O. D., Griswold, B. F., Fu, Q., Backer, J. F. A. D., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.841981 · Cited by 273 · see citing works
Extracellular Matrix Proteoglycans Control the Fate of Bone Marrow Stromal Cells
Bi, Y., Stuelten, C. H., Kilts, T. M., Wadhwa, S., Iozzo, R. V., Robey, P. G., Chen, X., & Young, M. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500573200 · Cited by 256 · see citing works
Molecular regulation of hepatic fibrogenesis
Olaso, E., & Friedman, S. L. (1998) · Journal of Hepatology · doi:10.1016/s0168-8278(98)80269-9 · Cited by 244 · see citing works
A macrophage-pericyte axis directs tissue restoration via amphiregulin-induced transforming growth factor beta activation
Minutti, C. M., Modak, R. V., Macdonald, F., Li, F., Smyth, D. J., Dorward, D. A., Blair, N., Husovsky, C., Muir, A., Giampazolias, E., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.01.008 · Cited by 228 · see citing works
Regulation of Myostatin in Vivo by Growth and Differentiation Factor-Associated Serum Protein-1: A Novel Protein with Protease Inhibitor and Follistatin Domains
Hill, J. J., Qiu, Y., Hewick, R. M., & Wolfman, N. M. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0366 · Cited by 225 · see citing works
Adenoviral Gene Transfer of Active Human Transforming Growth Factor-β2 Elevates Intraocular Pressure and Reduces Outflow Facility in Rodent Eyes
Shepard, A. R., Millar, J. C., Pang, I.-H., Jacobson, N., Wang, W.-H., & Clark, A. F. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4567 · Cited by 219 · see citing works
Inhibition of Endogenous TGF-β During Experimental Osteoarthritis Prevents Osteophyte Formation and Impairs Cartilage Repair
Scharstuhl, A., Glansbeek, H. L., van Beuningen, H. M., Vitters, E. L., van der Kraan, P. M., & van den Berg, W. B. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.507 · Cited by 217 · see citing works
Integrin-mediated regulation of TGFβ in fibrosis
Henderson, N. C., & Sheppard, D. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.10.005 · Cited by 209 · see citing works
α-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGFβ activation or collagen production across multiple models of organ fibrosis
Sun, K.-H., Chang, Y., Reed, N. I., & Sheppard, D. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00350.2015 · Cited by 200 · see citing works
Soluble Transforming Growth Factor-β Type II Receptor Inhibits Negative Remodeling, Fibroblast Transdifferentiation, and Intimal Lesion Formation But Not Endothelial Growth
Smith, J. D., Bryant, S. R., Couper, L. L., Vary, C., Gotwals, P. J., Koteliansky, V., & Lindner, V. (1999) · Circulation Research · doi:10.1161/01.res.84.10.1212 · Cited by 197 · see citing works
Activation of Rat Alveolar Macrophage-Derived Latent Transforming Growth Factor β-1 by Plasmin Requires Interaction with Thrombospondin-1 and its Cell Surface Receptor, CD36
Yehualaeshet, T., O'Connor, R. N., Green-Johnson, J. M., Mai, S., Silverstein, R. L., Murphy-Ullrich, J. E., & Khalil, N. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65183-8 · Cited by 180 · see citing works
Expression of myostatin pro domain results in muscular transgenic mice
Yang, J., Ratovitski, T., Brady, J. P., Solomon, M. B., Wells, K. D., & Wall, R. J. (2001) · Molecular Reproduction and Development · doi:10.1002/mrd.1097 · Cited by 177 · see citing works
Review of the activation of TGF-β in immunity
Taylor, A. W. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0708415 · Cited by 169 · see citing works
Integration of the TGF-β pathway into the cellular signalling network
Lutz, M., & Knaus, P. I. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(02)00058-x · Cited by 168 · see citing works
Endosomal signalling via exosome surface TGFβ‐1
Shelke, G. V., Yin, Y., Jang, S. C., Lässer, C., Wennmalm, S., Hoffmann, H. J., Li, L., Gho, Y. S., Nilsson, J. A., & Lötvall, J. O. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1650458 · Cited by 167 · see citing works
Integrins and integrin-related proteins in cardiac fibrosis
Chen, C., Li, R., Ross, R. S., & Manso, A. M. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.010 · Cited by 162 · see citing works
ATF3, an adaptive-response gene, enhances TGFβ signaling and cancer-initiating cell features in breast cancer cells
Yin, X. H., Wolford, C. C., Chang, Y.-S., McConoughey, S. J., Ramsey, S. A., Aderem, A. A., & Hai, T. (2010) · Journal of Cell Science · doi:10.1242/jcs.064915 · Cited by 160 · see citing works
Identification of a Novel Family of Cell-surface Proteins Expressed in Human Vascular Endothelium
Yang, R., Ng, C. K. D., Wasserman, S. M., Colman, S. D., Shenoy, S. G., Mehraban, F., Kömüves, L. G., Tomlinson, J. E., & Topper, J. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207410200 · Cited by 159 · see citing works
SPARC Inhibits Epithelial Cell Proliferation in Part through Stimulation of the Transforming Growth Factor-β–Signaling System
Schiemann, B. J., Neil, J. R., & Schiemann, W. P. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-01-0001 · Cited by 159 · see citing works
Pre‐culture period of mesenchymal stem cells in osteogenic media influences their in vivo bone forming potential
Castano‐Izquierdo, H., Álvarez-Barreto, J. F., van den Dolder, J., Jansen, J. A., Mikos, A. G., & Sikavitsas, V. I. (2007) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31082 · Cited by 155 · see citing works
αvβ6 integrin in wound healing and cancer of the oral cavity
Thomas, G. J., Nystrom, M. L., & Marshall, J. F. (2005) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2005.00374.x · Cited by 155 · see citing works
Submandibular gland morphogenesis: Stage-specific expression of TGF-?/EGF, IGF, TGF-?, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-?2, TGF-?3, and EGF-r null mutations
Jaskoll, T. F., & Melnick, M. (1999) · The Anatomical Record · doi:10.1002/(sici)1097-0185(19991101)256:3 · Cited by 153 · see citing works
<p>Blocking TGF-β Signaling To Enhance The Efficacy Of Immune Checkpoint Inhibitor</p>
Bai, X., Yi, M., Jiao, Y., Chu, Q., & Wu, K. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s224013 · Cited by 153 · see citing works
The Involvement of Aryl Hydrocarbon Receptor in the Activation of Transforming Growth Factor-β and Apoptosis
Zaher, H., Fernández‐Salguero, P. M., Letterio, J. J., Sheikh, M. S., Fornace, A. J., Roberts, A. B., & Gonzalez, F. J. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.2.313 · Cited by 151 · see citing works
Asbestos-Derived Reactive Oxygen Species Activate TGF-Β1
Pociask, D. A., Sime, P. J., & Brody, A. R. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700109 · Cited by 149 · see citing works
Impairment of NKG2D-Mediated Tumor Immunity by TGF-β
Lazarova, M., & Steinle, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02689 · Cited by 149 · see citing works
Function-blocking Integrin αvβ6 Monoclonal Antibodies
Weinreb, P. H., Simon, K. J., Rayhorn, P., Yang, W. J., Leone, D. R., Dolinski, B. M., Pearse, B. R., Yokota, Y., Kawakatsu, H., Atakilit, A., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312103200 · Cited by 149 · see citing works
Processing of Anti-Mullerian Hormone Regulates Receptor Activation by a Mechanism Distinct from TGF-β
di Clemente, N., Jamin, S. P., Lugovskoy, A. A., Carmillo, P., Ehrenfels, C. W., Picard, J., Whitty, A., Josso, N., Pepinsky, R. B., & Cate, R. L. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0273 · Cited by 146 · see citing works
αv integrins: key regulators of tissue fibrosis
Conroy, K. P., Kitto, L. J., & Henderson, N. C. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2407-9 · Cited by 146 · see citing works
PAI-1, fibrosis, and the elusive provisional fibrin matrix
Loskutoff, D. J., & Quigley, J. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11765 · Cited by 143 · see citing works
Role of transforming growth factor-β in the progression of heart failure
Lim, H., & Zhu, Y. Z. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6085-8 · Cited by 138 · see citing works
Smad7 in TGF-β-mediated negative regulation of gut inflammation
Monteleone, G., Pallone, F., & MacDonald, T. T. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.07.008 · Cited by 136 · see citing works
Amniotic Membrane for Ocular Surface Reconstruction: Donor Variations and the Effect of Handling on TGF-β Content
Hopkinson, A., McIntosh, R. S., Tighe, P. J., James, D. K., & Dua, H. S. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1415 · Cited by 133 · see citing works
Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis
Bian, Q., Ma, L., Jain, A., Crane, J. L., Kebaish, K. M., Wan, M., Zhang, Z., Guo, X.-D. E., Sponseller, P. D., Séguin, C. A., et al. (2017) · Bone Research · doi:10.1038/boneres.2017.8 · Cited by 130 · see citing works
Human monocytes and macrophages regulate immune tolerance via integrin αvβ8–mediated TGFβ activation
Kelly, A., Gunaltay, S., McEntee, C. P., Shuttleworth, E. E., Smedley, C., Houston, S. A., Fenton, T. M., Levison, S., Mann, E. R., & Travis, M. A. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171491 · Cited by 124 · see citing works
Macrophages play a key role in tissue repair and regeneration
Yu, Y.-J., Yue, Z., Xu, M.-L., Zhang, M., Shen, X., Ma, Z., Li, J., & Xie, X. (2022) · PeerJ · doi:10.7717/peerj.14053 · Cited by 118 · see citing works
Thrombospondin-1 in the trabecular meshwork: localization in normal and glaucomatous eyes, and induction by TGF-β1 and dexamethasone in vitro
Flügel‐Koch, C., Ohlmann, A., Fuchshofer, R., Welge‐Lüßen, U., & Tamm, E. R. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2004.07.005 · Cited by 120 · see citing works
Roles of TGF-β signaling pathway in tumor microenvirionment and cancer therapy
Zhao, H., Wei, J., & Sun, J. M. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107101 · Cited by 117 · see citing works
Pathogenesis of pleural fibrosis
Mutsaers, S. E., Prêle, C. M., Brody, A. R., & Idell, S. (2004) · Respirology · doi:10.1111/j.1440-1843.2004.00633.x · Cited by 117 · see citing works
Myofibroblasts and lung fibrosis induced by carbon nanotube exposure
Dong, J., & Ma, Q. (2016) · Particle and Fibre Toxicology · doi:10.1186/s12989-016-0172-2 · Cited by 113 · see citing works
Morphogen gradients, positional information, and Xenopus: Interplay of theory and experiment
Green, J. B. A. (2002) · Developmental Dynamics · doi:10.1002/dvdy.10170 · Cited by 98 · see citing works
IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition
Walsh, L. A., & Damjanovski, S. (2011) · Cell Communication and Signaling · doi:10.1186/1478-811x-9-10 · Cited by 100 · see citing works
Up-regulated Transcriptional Repressors SnoN and Ski Bind Smad Proteins to Antagonize Transforming Growth Factor-β Signals during Liver Regeneration
Macías‐Silva, M., Li, W., Leu, J. I.-J., Crissey, M. A. S., & Taub, R. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202403200 · Cited by 99 · see citing works
A blocking peptide for transforming growth factor-β1 activation prevents hepatic fibrosis in vivo
Kondou, H., Mushiake, S., Etani, Y., Miyoshi, Y., Michigami, T., & Ozono, K. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00377-5 · Cited by 99 · see citing works
The role of matricellular proteins in glaucoma
Wallace, D., Murphy-Ullrich, J. E., Downs, J. C., & O'Brien, C. J. (2014) · Matrix Biology · doi:10.1016/j.matbio.2014.03.007 · Cited by 97 · see citing works
Extracellular matrix provides an optimal niche for the maintenance and propagation of mesenchymal stem cells
Chen, X. (2010) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.20171 · Cited by 97 · see citing works
One size does not fit all: developing a cell-specific niche for in vitro study of cell behavior
Marinkovic, M., Block, T. J., Rakian, R., Li, Q., Wang, E., Reilly, M. A., Dean, D. D., & Chen, X. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.01.004 · Cited by 95 · see citing works
Overexpression of TGF-β by infiltrated granulocytes correlates with the expression of collagen mRNA in pancreatic cancer
Aoyagi, Y., Oda, T., Kinoshitá, T., Nakahashi, C., Hasebe, T., Ohkohchi, N., & Ochiai, A. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602141 · Cited by 90 · see citing works
Upregulation of TGF-β1 Expression May Be Necessary but Is Not Sufficient for Excessive Scarring
Campaner, A. B., Ferreira, L. M., Gragnani, A., Bruder, J. M., Cusick, J. L., & Morgan, J. R. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700200 · Cited by 84 · see citing works
Roles of TGF β and FGF Signals in the Lens: Tropomyosin Regulation for Posterior Capsule Opacity
Kubo, E., Shibata, T., Singh, D. P., & Sasaki, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103093 · Cited by 85 · see citing works
Implication of Transforming Growth Factor–β1 in Chagas Disease Myocardiopathy
de Araújo-Jorge, T. C., Waghabi, M. C., Hasslocher‐Moreno, A. M., Xavier, S. S., Higuchi, M. D. L., Kéramidas, M., Bailly, S., & Feige, J. (2002) · The Journal of Infectious Diseases · doi:10.1086/345882 · Cited by 85 · see citing works
A system for the direct co-culture of endothelium on smooth muscle cells
Lavender, M. D., Pang, Z., Wallace, C. S., Niklason, L. E., & Truskey, G. A. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.11.045 · Cited by 83 · see citing works
Pharmacologic inhibition of lactate production prevents myofibroblast differentiation
Kottmann, R. M., Trawick, E. C., Judge, J., Wahl, L. A., Epa, A. P., Owens, K. M., Thatcher, T. H., Phipps, R. P., & Sime, P. J. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00058.2015 · Cited by 82 · see citing works
Immune‐ and non‐immune‐mediated roles of regulatory T‐cells during wound healing
Zaiss, D. M. W., Minutti, C. M., & Knipper, J. A. (2019) · Immunology · doi:10.1111/imm.13057 · Cited by 81 · see citing works
Differential Response to Exogenous and Endogenous Myostatin in Myoblasts Suggests that Myostatin Acts as an Autocrine Factorin Vivo
Rı́os, R., Fernández‐Nocelo, S., Carneiro, I., Arce, V. M., & Devesa, J. (2004) · Endocrinology · doi:10.1210/en.2003-1166 · Cited by 75 · see citing works
Transforming growth factor-beta (TGF-β) in prostate cancer: A dual function mediator?
Mirzaei, S., Paskeh, M. D. A., Saghari, Y., Zarrabi, A., Hamblin, M. R., Entezari, M., Hashemi, M., Aref, A. R., Hushmandi, K., Kumar, A. P., et al. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.02.094 · Cited by 74 · see citing works
Natural Killer Cell Cytotoxicity and Immunosuppressive Cytokines (IL-10, TGF- β 1) in Patients with Gastric Cancer
Szkaradkiewicz, A., Karpiński, T. M. M., Drews, M., Borejsza‐Wysocki, M., Majewski, P., & Andrzejewska, E. (2010) · BioMed Research International · doi:10.1155/2010/901564 · Cited by 74 · see citing works
Transforming growth factor-β1 produced by hippocampal cells modulates microglial reactivity in culture
Herrera‐Molina, R., & Rommy von Bernhardi, M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.003 · Cited by 74 · see citing works
The Latent Transforming Growth Factor-β–binding Protein-1 Promotes In Vitro Differentiation of Embryonic Stem Cells into Endothelium
Gualandris, A., Annes, J. P., Arese, M., Noguera, I., Jurukovski, V., & Rifkin, D. B. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4295 · Cited by 72 · see citing works
Self-citation
Autocrine TGFβ signaling mediates vitamin D3 analog‐induced growth inhibition in breast cells
Yang, L., Yang, J., Venkateswarlu, S., Ko, T. C., & Brattain, M. G. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1125 · Cited by 72 · see citing works
Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture
Xu, Z., Castellino, F., & Ploplis, V. A. (2009) · Blood · doi:10.1182/blood-2009-09-244962 · Cited by 71 · see citing works
How many aqueous humor outflow pathways are there?
Costagliola, C., dell’Omo, R., Agnifili, L., Bartollino, S., Fea, A. M., Uva, M. G., Zeppa, L., & Mastropasqua, L. (2019) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2019.10.002 · Cited by 70 · see citing works
Pivotal role for TGF-β in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy
de Araújo-Jorge, T. C., Waghabi, M. C., Soeiro, M. D. N. C., Kéramidas, M., Bailly, S., & Feige, J. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.08.002 · Cited by 70 · see citing works
The role of the insulin-like growth factor-I receptor in malignancy: An update
Seccareccia, E., & Brodt, P. (2012) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2012.09.003 · Cited by 68 · see citing works
Transforming Growth Factor- β Signaling in Normal and Malignant Hematopoiesis
Isufi, I., Seetharam, M., Zhou, L., Sohal, D. P. S., Opalinska, J., Pahanish, P., & Verma, A. K. (2007) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2007.0009 · Cited by 68 · see citing works
Skeletal development: insights from targeting the mouse genome
Horton, W. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14119-0 · Cited by 68 · see citing works
Binding of TGF-β1 latency-associated peptide (LAP) to αvβ6 integrin modulates behaviour of squamous carcinoma cells
Thomas, G. J., Hart, I. R., Speight, P. M., & Marshall, J. F. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600545 · Cited by 67 · see citing works
Dimerization of the Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor
Byrd, J. C., Park, J. H. Y., Schaffer, B. S., Garmroudi, F., & MacDonald, R. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001273200 · Cited by 66 · see citing works
Characterization of Interleukin-4–Stimulated Nasal Polyp Fibroblasts
Steinke, J. W., Crouse, C. D., Bradley, D. T., Hise, K., Lynch, K. R., Kountakis, S. E., & Borish, L. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0071oc · Cited by 64 · see citing works
Modulation of bcl-2 and p27 in human primitive proliferating hematopoietic progenitors by autocrine TGF-β1 is a cell cycle–independent effect and influences their hematopoietic potential
Pierelli, L., Marone, M., Bonanno, G., Mozzetti, S., Rutella, S., Roberta Morosetti, A., Rumi, C., Mancuso, S., Leone, G. G. M., & Scambia, G. (2000) · Blood · doi:10.1182/blood.v95.10.3001 · Cited by 63 · see citing works
Synergy between anti‐endoglin (CD105) monoclonal antibodies and TGF‐β in suppression of growth of human endothelial cells
She, X., Matsuno, F., Harada, N., Tsai, H., & Seon, B. K. (2003) · International Journal of Cancer · doi:10.1002/ijc.11551 · Cited by 62 · see citing works
Activation of Transforming Growth Factor β in Chondrocytes Undergoing Endochondral Ossification
D’Angelo, M., Sarment, D. P., Billings, P. C., & Pacifici, M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.12.2339 · Cited by 61 · see citing works
Systemic transforming growth factor-beta in patients with bone marrow fibrosis—pathophysiological implications
Rameshwar, P., Chang, V. T.-S., Thacker, U. F., & Gascón, P. (1998) · American Journal of Hematology · doi:10.1002/(sici)1096-8652(199810)59:2 · Cited by 61 · see citing works
Noncanonical WNT5A controls the activation of latent TGF-β to drive fibroblast activation and tissue fibrosis
Trinh‐Minh, T., Chen, C.-W., Manh, C. T., Li, Y., Zhu, H., Zhou, X., Chakraborty, D., Zhang, Y., Rauber, S., Dees, C., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci159884 · Cited by 67 · see citing works
NRF2 deficiency reduces life span of mice administered thoracic irradiation
Travis, E. L., Rachakonda, G., Zhou, X., Korhonen, K. E., Sekhar, K. R., Biswas, S., & Freeman, M. L. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.038 · Cited by 60 · see citing works
Identification of binding partners interacting with the α1-N-propeptide of type V collagen
Symoens, S., Renard, M., Bonod‐Bidaud, C., Syx, D., Vaganay, E., Malfait, F., Ricard‐Blum, S., Kessler, E., Laer, L. V., Coucke, P. J., et al. (2010) · Biochemical Journal · doi:10.1042/bj20101061 · Cited by 60 · see citing works
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-β1 secretion and the resolution of inflammation
Huynh, M.-L. N., Fadok, V. A., & Henson, P. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200211638 · Cited by 59 · see citing works
Integrin αvβ8-Mediated Activation of Transforming Growth Factor-β Inhibits Human Airway Epithelial Proliferation in Intact Bronchial Tissue
Fjellbirkeland, L., Cambier, S., Broaddus, V. C., Hill, A. C., Brunetta, P. G., Dolganov, G., Jablons, D. M., & Nishimura, S. L. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63681-4 · Cited by 59 · see citing works
Human cytomegalovirus infection of cells of hematopoietic origin: HCMV-induced immunosuppression, immune evasion, and latency
Bego, M. G., & Jeor, S. S. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2005.11.012 · Cited by 58 · see citing works
Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol
Judge, J., Nagel, D. J., Owens, K. M., Rackow, A. R., Phipps, R. P., Sime, P. J., & Kottmann, R. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197936 · Cited by 58 · see citing works
TGF-β signaling pathway: Therapeutic targeting and potential for anti-cancer immunity
Ali, S., Rehman, M. U., Yatoo, A. M., Arafah, A. M., Khan, A., Rashid, S., Majid, S., Ali, A., & Ali, M. N. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175678 · Cited by 57 · see citing works
Conformation and Self-association of Human Recombinant Transforming Growth Factor-β3 in Aqueous Solutions
Pellaud, J., Schote, U., Arvinte, T., & Seelig, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7699 · Cited by 57 · see citing works
Diabetic kidney disease: impact of puberty
Lane, P. H. (2002) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00368.2001 · Cited by 57 · see citing works
TSG6‐Exo@CS/GP Attenuates Endometrium Fibrosis by Inhibiting Macrophage Activation in a Murine IUA Model
Sun, H., Dong, J., Fu, Z., Lu, X., Chen, X., Lei, H., Xiao, X., Chen, S., Lu, J., Su, D., et al. (2024) · Advanced Materials · doi:10.1002/adma.202308921 · Cited by 56 · see citing works
Real Time Kinetics of Insulin-like Growth Factor II (IGF-II) Interaction with the IGF-II/Mannose 6-Phosphate Receptor
Linnell, J., Groeger, G., & Hassan, A. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100700200 · Cited by 56 · see citing works

Measurement of Active TGF-β Generated by Cultured Cells
Mazzieri, R., Munger, J. S., & Rifkin, D. B. (2003) · Humana Press eBooks · doi:10.1385/1-59259-053-5:13 · Cited by 24 · see citing works
Self-citation
Latent-TGF-β: An overview
Lawrence, D. A. (2001) · Molecular and Cellular Biochemistry · doi:10.1023/a:1010819716023 · Cited by 117 · see citing works
Latency and activation in the control of TGF-β
Barcellos‐Hoff, M. H. (1996) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/bf02017391 · Cited by 121 · see citing works
7 TGF-β Bioavailability: Latency, Targeting, and ActivationPreprint
Dabovic, B., & Rifkin, D. B. (2008) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969752.50.179 · Cited by 7 · see citing works
Self-citation
Role of TGF-? in immune-evasion of cancer
Beck, C., Schreiber, H. W., & Rowley, D. A. (2001) · Microscopy Research and Technique · doi:10.1002/1097-0029(20010215)52:4 · Cited by 103 · see citing works

Authors: Gleizes, P., Munger, J. S., Nunes, I., Harpel, J. G., Mazzieri, R., Noguera, I., & Rifkin, D. B.
Affiliations: NYU Langone Health (US)
Corresponding author: Gleizes, Pierre‐Emmanuel
ORCID: Gleizes, Pierre‐Emmanuel
Munger, John S.
Mazzieri, Roberta
Rifkin, Daniel B.
Venue: STEM CELLS
Publisher: Oxford University Press (OUP)
Published: 1997-05
Volume: 15
Issue: 3
Pages: 190-197
ISSN: 1066-5099 (ISSN-L)
1549-4918
DOI: 10.1002/stem.150190
OpenAlex: W2064881656
Cited by: 266
References: 72
Citations by year: 2026: 6 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 11 · 2021: 2 · 2020: 4 · 2019: 10 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 8 · 2014: 12 · 2013: 7 · 2012: 9
FWCI: 0.60
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Stem Cells (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ca023753-22)
National Eye Institute (EY-06537)
National Cancer Institute (CA23753)
National Institute of General Medical Sciences (T32GM007238, T32GM 07238)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Keywords: TGF-beta, latent TGF-beta complex, latent TGF-beta activation
MeSH terms: Animals, Stem Cells, Transforming Growth Factor beta

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

TGF‐β Latency: Biological Significance and Mechanisms of Activation

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks