The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Complement-Induced Impairment of Innate Immunity During Sepsis
Abstract
This study defines the molecular basis for defects in innate immunity involving neutrophils during cecal ligation/puncture (CLP)-induced sepsis in rats. Blood neutrophils from CLP rats demonstrated defective phagocytosis and defective assembly of NADPH oxidase, the latter being due to the inability of p47phox to translocate from the cytosol to the cell membrane of neutrophils after cell stimulation by phorbol ester (PMA). The appearance of these defects was prevented by in vivo blockade of C5a in CLP rats. In vitro exposure of neutrophils to C5a led to reduced surface expression of C5aR and defective assembly of NADPH oxidase, as defined by failure in phosphorylation of p47phox and its translocation to the cell membrane, together with failure in phosphorylation of p42/p44 mitogen-activated protein kinases. These data identify a molecular basis for defective innate immunity involving neutrophils during sepsis.
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Citations
Cites
Oxygen-dependent and oxygen-independent mechanisms of microbicidal activity of neutrophils
Elsbach, P., & Weiss, J. (1985) · Immunology Letters · doi:10.1016/0165-2478(85)90163-4 · Cited by 52
Cited by
Harmful molecular mechanisms in sepsis
Rittirsch, D., Flierl, M. A., & Ward, P. A. (2008) · Nature Reviews Immunology · doi:10.1038/nri2402 · Cited by 1,202
Self-citationNovel strategies for the treatment of sepsis
Riedemann, N. C., Guo, R.-F., & Ward, P. A. (2003) · Nature Medicine · doi:10.1038/nm0503-517 · Cited by 773
Self-citationThe dark side of C5a in sepsis
Ward, P. A. (2004) · Nature Reviews Immunology · doi:10.1038/nri1269 · Cited by 422
Self-citationTherapeutic effects of lysophosphatidylcholine in experimental sepsis
Yan, J.-J., Jung, J.-S., Lee, J.-E., Lee, J., Huh, S.-O., Kim, H.-S., Jung, K. C., Cho, J.-Y., Nam, J.-S., Suh, H.-W., et al. (2004) · Nature Medicine · doi:10.1038/nm989 · Cited by 329
C5a anaphylatoxin and its role in critical illness-induced organ dysfunction
Wood, A. J. T., Vassallo, A., Summers, C., Chilvers, E. R., & Conway‐Morris, A. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.13028 · Cited by 45
Metadata
- Authors
- Huber-Lang, M. S., Younkin, E. M., Sarma, J. V., McGuire, S. R., Lu, K. T., Guo, R. F., Padgaonkar, V. A., Curnutte, J. T., Erickson, R., & Ward, P. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-09
- Volume
- 169
- Issue
- 6
- Pages
- 3223-3231
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1890847758
- Cited by
- 200
- References
- 1
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Huber-Lang, M. S., Younkin, E. M., Sarma, J. V., McGuire, S. R., Lu, K. T., Guo, R. F., Padgaonkar, V. A., Curnutte, J. T., Erickson, R., & Ward, P. A. (2002). Complement-Induced Impairment of Innate Immunity During Sepsis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.169.6.3223
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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