The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Protective Effects of IL-6 Blockade in Sepsis Are Linked to Reduced C5a Receptor Expression
Abstract
IL-6 is known to be an important pro- and anti-inflammatory cytokine, which is up-regulated during sepsis. Our previous work has suggested a role for IL-6 in the up-regulation of C5aR in sepsis. We reported earlier that interception of C5a or C5aR results in improved outcomes in experimental sepsis. Using the cecal ligation/puncture (CLP) model in mice, we now demonstrate that treatment with anti-IL-6 Ab (anti-IL-6) results in significantly improved survival, dependent on the amount of Ab infused. CLP animals showed significantly increased binding of 125I-labeled anti-C5aR to organs when compared to either control mice at 0 h or CLP animals infused with normal rabbit 125I-labeled IgG. Binding of 125I-labeled anti-C5aR to lung, liver, kidney, and heart was significantly decreased in anti-IL-6-treated animals 6 h after CLP. RT-PCR experiments with mRNA isolated from various organs obtained 3, 6, and 12 h after CLP demonstrated increased C5aR mRNA expression during the onset of sepsis, which was greatly suppressed in CLP mice treated with anti-IL-6. These data suggest that IL-6 plays an important role in the increased expression of C5aR in lung, liver, kidney, and heart during the development of sepsis in mice and that interception of IL-6 leads to reduced expression of C5aR and improved survival.
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1 retracted
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“I nterleukin-6 is a 212-aa polypeptide (1) known to have a variety of biological effects.”
Impaired immune and acute-phase responses in interleukin-6-deficient mice
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“It has been reported that IL-6 knockout mice do not show improved survival in CLP-induced sepsis (39) and that they suffer from impaired immune and acute-phase responses (40).”
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Cited by
Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer
Jones, S. A., & Jenkins, B. J. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0066-7 · Cited by 1,102
Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?
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Novel strategies for the treatment of sepsis
Riedemann, N. C., Guo, R.-F., & Ward, P. A. (2003) · Nature Medicine · doi:10.1038/nm0503-517 · Cited by 773
Self-citationImmunotherapeutic Implications of Il-6 Blockade for Cytokine Storm
Tanaka, T., Narazaki, M., & Kishimoto, T. (2016) · Immunotherapy · doi:10.2217/imt-2016-0020 · Cited by 708
Systemic inflammation after trauma
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Metadata
- Authors
- Riedemann, N. C., Neff, T. A., Guo, R.-F., Bernacki, K. D., Laudes, I. J., Sarma, J. V., Lambris, J. D., & Ward, P. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-01-01
- Volume
- 170
- Issue
- 1
- Pages
- 503-507
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1569271652
- Cited by
- 330
- References
- 40
- FWCI
- 14.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Riedemann, N. C., Neff, T. A., Guo, R.-F., Bernacki, K. D., Laudes, I. J., Sarma, J. V., Lambris, J. D., & Ward, P. A. (2003). Protective Effects of IL-6 Blockade in Sepsis Are Linked to Reduced C5a Receptor Expression. The Journal of Immunology. https://doi.org/10.4049/jimmunol.170.1.503
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