Novel Quantitative Trait Loci Controlling Development of Experimental Autoimmune Encephalomyelitis and Proportion of Lymphocyte Subpopulations
Open accessAbstract
The B10.RIII mouse strain (H-2r) develops chronic experimental autoimmune encephalomyelitis (EAE) upon immunization with the myelin basic protein 89–101 peptide. EAE was induced and studied in a backcross between B10.RIII and the EAE-resistant RIIIS/J strain (H-2r), and a complete genome scan with microsatellite markers was performed. Five loci were significantly linked to different traits and clinical subtypes of EAE on chromosomes 1, 5, 11, 15, and 16, three of the loci having sex specificity. The quantitative trait locus on chromosome 15 partly overlapped with the Eae2 locus, previously identified in crosses between the B10.RIII and RIIIS/J mouse strains. The loci on chromosomes 11 and 16 overlapped with Eae loci identified in other mouse crosses. By analyzing the backcross animals for lymphocyte phenotypes, the proportion of B and T cells in addition to the levels of CD4+CD8− and CD4−CD8+ T cells and the CD4+/CD8+ ratio in spleen were linked to different loci on chromosomes 1, 2, 3, 5, 6, 11, and 15. On chromosome 16, we found significant linkage to spleen cell proliferation. Several linkages overlapped with the quantitative trait loci for disease phenotypes. The identification of subphenotypes that are linked to the same loci as disease traits could be most useful in the search for candidate genes and biological pathways involved in the pathological process.
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The Eae39 locus on mouse chromosome 5 was previously linked to experimental autoimmune encephalomyelitis and also influences collagen-induced arthritis development and severity.
“The genetic locus Eae39, located on mouse chromosome 5, was previously linked to experimental autoimmune encephalomyelitis (EAE), an experimental model for multiple sclerosis. Subsequently, it was also shown to influence CIA development and severity [8, 10].”
From The oncoprotein TBX3 is controlling severity in experimental arthritis (2019) · cites this paper as [10]
The Linkage analysis section identifies the chromosome 5 EAE locus as Eae26, not Eae39, and the Discussion says no Eae locus had previously been reported on mouse chromosome 5. The Discussion mentions other arthritis loci on chromosome 5 but does not link Eae26 to collagen-induced arthritis development or severity. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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- Authors
- Karlsson, J., Zhao, X., Lonskaya, I., Neptin, M., Holmdahl, R., & Andersson, A.
- Affiliations
- Lund University (SE)
- Department for Cell and Molecular Biology, Section for Medical Inflammation Research, University of Lund , Lund ,
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-01
- Volume
- 170
- Issue
- 2
- Pages
- 1019-1026
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1813779047
- Cited by
- 43
- References
- 47
- Citations by year
- 2023: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2014: 1 · 2013: 3
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Vetenskapsrådet
- Reumatikerförbundet
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- experimental autoimmune encephalomyelitis, quantitative trait loci, lymphocyte subsets, CD4/CD8 ratio, T and B cells, spleen cell proliferation, disease subphenotypes, candidate genes, genome scan
- MeSH terms
- Animals, Crosses, Genetic, Encephalomyelitis, Autoimmune, Experimental, Female, Genotype, Genetic Linkage, Male, Mice, Inbred C57BL, Mice, Inbred Strains, Incidence, Immunophenotyping, Lymphocyte Subsets, Lymphocyte Count, Quantitative Trait Loci, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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