The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Cutting Edge: Distinct Toll-Like Receptor 2 Activators Selectively Induce Different Classes of Mediator Production from Human Mast Cells
Open accessAbstract
Mast cells play a critical role in host defense against bacterial infection. Murine mast cells produce cytokines in response to bacterial peptidoglycan and LPS via Toll-like receptor (TLR) TLR2- and TLR4-dependent mechanisms. The expression of TLRs by human mast cells and responses to known TLR activators was examined. Human mast cells expressed mRNA for TLR1, TLR2, and TLR6 but not TLR4. Bacterial peptidoglycan and yeast zymosan were potent inducers of GM-CSF and IL-1β and also induced substantial short-term cysteinyl leukotriene generation. In contrast, a synthetic triacylated lipopeptide induced short-term degranulation but failed to induce cysteinyl leukotriene production. The TLR4 activator Escherichia coli LPS did not induce a GM-CSF, IL-1β leukotriene, or degranulation response. These data demonstrate highly selective production of different classes of mast cell mediators in response to distinct TLR activators of potential importance to the host response to bacterial or fungal pathogens.
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Cites
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Cited by
Mast Cell: A Multi-Functional Master Cell
Krystel-Whittemore, M., Dileepan, K. N., & Wood, J. G. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00620 · Cited by 890
Theoharides, T. C., Alysandratos, K.-D., Angelidou, A., Delivanis, D.-A., Sismanopoulos, N., Zhang, B., Asadi, S., Vasiadi, M., Weng, Z., Miniati, A., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.014 · Cited by 680
The role of the mast cell in the pathophysiology of asthma
Bradding, P., Walls, A. F., & Holgate, S. T. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.02.039 · Cited by 573
Recognition of Staphylococcus aureus by the Innate Immune System
Fournier, B., & Philpott, D. J. (2005) · Clinical Microbiology Reviews · doi:10.1128/cmr.18.3.521-540.2005 · Cited by 477
Differential release of mast cell mediators and the pathogenesis of inflammation
Theoharides, T. C., Kempuraj, D., Tagen, M., Conti, P., & Kalogeromitros, D. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00519.x · Cited by 425
Metadata
- Authors
- McCurdy, J. D., Olynych, T. J., Maher, L. H., & Marshall, J. S.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-02
- Volume
- 170
- Issue
- 4
- Pages
- 1625-1629
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1791079802
- Cited by
- 349
- References
- 29
- FWCI
- 9.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- McCurdy, J. D., Olynych, T. J., Maher, L. H., & Marshall, J. S. (2003). Cutting Edge: Distinct Toll-Like Receptor 2 Activators Selectively Induce Different Classes of Mediator Production from Human Mast Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.170.4.1625
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