The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Blockade of S100A8 and S100A9 Suppresses Neutrophil Migration in Response to Lipopolysaccharide
Open accessAbstract
Recently, proinflammatory activities had been described for S100A8 and S100A9, two proteins found at inflammatory sites and within the neutrophil cytoplasm. In this study, we investigated the role of these proteins in neutrophil migration in vivo in response to LPS. LPS was injected into the murine air pouch, which led to the release of S100A8, S100A9, and S100A8/A9 in the pouch exudates that preceded accumulation of neutrophils. Passive immunization against S100A8 and S100A9 led to a 52% inhibition of neutrophil migration in response to LPS at 3 h postinjection. Injection of LPS was also associated with an increase in peripheral blood neutrophils and the presence in serum of S100A9 and S100A8/A9. Intravenous injection of S100A8, S100A9, or S100A8/A9 augmented the number of circulating neutrophils and diminished the number of neutrophils in the bone marrow, demonstrating that S100A8 and S100A9 induced the mobilization of neutrophils from the bone marrow to the blood. Finally, passive immunization with anti-S100A9 inhibited the neutrophilia associated with LPS injection in the air pouch. These results suggest that S100A8 and S100A9 play a role in the inflammatory response to LPS by inducing the release of neutrophils from the bone marrow and directing their migration to the inflammatory site.
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Cites
Human Neutrophil-Mediated Nonoxidative Antifungal Activity against Cryptococcus neoformans
Mambula, S. S., Simons, E. R., Hastey, R., Selsted, M. E., & Levitz, S. M. (2000) · Infection and Immunity · doi:10.1128/iai.68.11.6257-6264.2000 · Cited by 104
Cited by
Vogl, T., Tenbrock, K., Ludwig, S., Leukert, N., Ehrhardt, C., van Zoelen, M. A. D., Nacken, W., Foell, D., van der Poll, T., Sorg, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1638 · Cited by 1,418
Kowanetz, M., Wu, X., Lee, J., Tan, M., Hagenbeek, T., Qu, X., Yu, L., Ross, J., Korsisaari, N., Cao, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015855107 · Cited by 663
Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins
Zenz, R., Eferl, R., Kenner, L., Florin, L., Hummerich, L., Mehic, D., Scheuch, H., Angel, P., Tschachler, E., & Wagner, E. F. (2005) · Nature · doi:10.1038/nature03963 · Cited by 599
Guilloteau, K., Paris, I., Pedretti, N., Boniface, K., Juchaux, F., Huguier, V., Guillet, G., Bernard, F.-X., Lecron, J.-C., & Morel, F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902464 · Cited by 353
Sunahori, K., Yamamura, M., Yamana, J., Takasugi, K., Kawashima, M., Yamamoto, H., Chazin, W. J., Nakatani, Y., Yui, S., & Makino, H. (2006) · Arthritis Research & Therapy · doi:10.1186/ar1939 · Cited by 321
Metadata
- Authors
- Vandal, K., Rouleau, P., Boivin, A., Ryckman, C., Talbot, M., & Tessier, P. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-09-01
- Volume
- 171
- Issue
- 5
- Pages
- 2602-2609
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2145120842
- Cited by
- 223
- References
- 1
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Blockade of S100A8 and S100A9 Suppresses Neutrophil Migration in Response to Lipopolysaccharide. https://app.cochat.ai/papers/10.4049/jimmunol.171.5.2602
- The paper
- Vandal, K., Rouleau, P., Boivin, A., Ryckman, C., Talbot, M., & Tessier, P. A. (2003). Blockade of S100A8 and S100A9 Suppresses Neutrophil Migration in Response to Lipopolysaccharide. The Journal of Immunology. https://doi.org/10.4049/jimmunol.171.5.2602
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