The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis
Open accessAbstract
S100A8 and S100A9, two Ca 2+-binding proteins of the S100 family, are secreted as a heterodimeric complex (S100A8/A9) from neutrophils and monocytes/macrophages. Serum and synovial fluid levels of S100A8, S100A9, and S100A8/A9 were all higher in patients with rheumatoid arthritis (RA) than in patients with osteoarthritis (OA), with the S100A8/A9 heterodimer being prevalent. By two-color immunofluorescence labeling, S100A8/A9 antigens were found to be expressed mainly by infiltrating CD68+ macrophages in RA synovial tissue (ST). Isolated ST cells from patients with RA spontaneously released larger amounts of S100A8/A9 protein than did the cells from patients with OA. S100A8/A9 complexes, as well as S100A9 homodimers, stimulated the production of proinflammatory cytokines, such as tumor necrosis factor alpha, by purified monocytes and in vitro-differentiated macrophages. S100A8/A9-mediated cytokine production was suppressed significantly by p38 mitogen-activated protein kinase (MAPK) inhibitors and almost completely by nuclear factor kappa B (NF-κB) inhibitors. NF-κB activation was induced in S100A8/A9-stimulated monocytes, but this activity was not inhibited by p38 MAPK inhibitors. These results indicate that the S100A8/A9 heterodimer, secreted extracellularly from activated tissue macrophages, may amplify proinflammatory cytokine responses through activation of NF-κB and p38 MAPK pathways in RA.
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Self-citationThe codependence of angiogenesis and chronic inflammation
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Cited by
Donato, R., R. Cannon, B., Sorci, G., Riuzzi, F., Hsu, K., J. Weber, D., & L. Geczy, C. (2013) · Current Molecular Medicine · doi:10.2174/156652413804486214 · Cited by 1,316
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HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins
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Role of S100 proteins in health and disease
Gonzalez, L. L., Garrie, K., & Turner, M. D. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118677 · Cited by 361
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Metadata
- Authors
- Sunahori, K., Yamamura, M., Yamana, J., Takasugi, K., Kawashima, M., Yamamoto, H., Chazin, W. J., Nakatani, Y., Yui, S., & Makino, H.
- Venue
- Arthritis Research & Therapy
- Published
- 2006-04-13
- Volume
- 8
- Issue
- 3
- Pages
- R69-R69
- ISSN
- 1478-6354 (ISSN-L)
- OpenAlex
- W1774714795
- Cited by
- 321
- References
- 44
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis. https://app.cochat.ai/papers/10.1186/ar1939
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- Sunahori, K., Yamamura, M., Yamana, J., Takasugi, K., Kawashima, M., Yamamoto, H., Chazin, W. J., Nakatani, Y., Yui, S., & Makino, H. (2006). The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis. Arthritis Research & Therapy. https://doi.org/10.1186/ar1939
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