Cited by 173Immune Response and InflammationImmune responses and vaccinationsImmunotherapy and Immune Responses

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Toll-Like Receptor 4 Dependence of Innate and Adaptive Immunity to Salmonella : Importance of the Kupffer Cell Network

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Vazquez-Torres, Andrés, Vallance, Bruce A, Bergman, Molly A, Finlay, B Brett, Cookson, Brad T, Jones-Carson, Jessica, Fang, Ferric C·2004·The Journal of Immunology

DOI 10.4049/jimmunol.172.10.6202

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Abstract

Mammalian cells recognize LPS from Gram-negative bacteria via the Toll-like receptor 4 (TLR4) complex. During experimental Salmonella infection, C3H/HeJ mice carrying a dominant-negative mutation in TLR4 exhibited delayed chemokine production, impaired NO generation, and attenuated cellular immune responses. However, dramatically enhanced bacterial growth within the Kupffer cell network before the recruitment of inflammatory cells appeared to be primarily responsible for the early demise of Salmonella-infected TLR4-deficient mice. LPS-TLR4 signaling plays an essential role in the generation of both innate and adaptive immune responses throughout the course of infection with Gram-negative bacteria. Alternative pattern-recognition receptors cannot completely compensate for the loss of TLR4, and compensation occurs at the expense of an increased microbial burden.

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Authors: Vazquez-Torres, A., Vallance, B. A., Bergman, M. A., Finlay, B. B., Cookson, B. T., Jones-Carson, J., & Fang, F. C.
Affiliations: Department of Microbiology, University of Colorado Health Sciences Center , Denver, CO 80262
University of British Columbia (CA)
University of Washington (US)
ORCID: Vallance, Bruce A
Finlay, B Brett
Fang, Ferric C
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2004-05
Volume: 172
Issue: 10
Pages: 6202-6208
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.172.10.6202
OpenAlex: W2138298422
Cited by: 173
References: 39
Citations by year: 2026: 4 · 2025: 7 · 2024: 3 · 2022: 1 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 8 · 2016: 6 · 2015: 11 · 2014: 7 · 2013: 7 · 2012: 17
FWCI: 6.14
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (AI54959, AI39557)
National Institute of Allergy and Infectious Diseases (AI47242, AI 54959, AI 39557, R01AI047242, AI-10181)
National Center for Research Resources (K01RR016082, RR16082)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: TLR4, salmonellosis, Kupffer cells, lipopolysaccharide signaling, innate immunity, adaptive immunity, chemokine production, nitric oxide, TLR4-deficient mice, bacterial clearance, Gram-negative bacteria
MeSH terms: Animals, Bacterial Proteins, Cytotoxicity, Immunologic, Immunity, Innate, Kupffer Cells, Liver, Membrane Glycoproteins, Mice, Inbred C3H, Phagocytosis, Receptors, Cell Surface, Salmonella Infections, Animal, Signal Transduction, Macrophages, Peritoneal, Mice, Knockout, Chemokines, CXC, Salmonella enterica, Genetic Predisposition to Disease, Mice, Congenic, Neutrophil Infiltration, Toll-Like Receptors, Toll-Like Receptor 4, Mice

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Toll-Like Receptor 4 Dependence of Innate and Adaptive Immunity to Salmonella : Importance of the Kupffer Cell Network

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