Aberrant Toll Receptor Expression and Endotoxin Hypersensitivity in Mice Lacking a Functional TGF-β1 Signaling Pathway
Open accessAbstract
TGF-β1 plays a central role in maintaining normal immune function and deficiency of this potent immunosuppressive molecule is linked to uncontrolled inflammation, cachexia, and multiorgan failure as seen in the TGF-β1 null mouse. Infiltration of inflammatory cells into vital organs of the null mouse is accompanied by increased gene expression of inflammatory cytokines, including TNF-α and IL-1β, as well as inducible NO synthase, each regulated by NF-κB. Treatment with the proteasome inhibitor MG132 to prevent NF-κB activation dramatically reduced NO production and expression of inflammatory cytokines. This inflammatory phenotype with NF-κB activation in the TGF-β1 null mouse, in the absence of any identifiable pathogen, suggested activation of innate immune responses. Because Toll-like receptors (TLR) are essential in the activation of innate immunity, we examined inflamed tissue from TGF-β1 null and wild-type mice for expression of TLR4, the receptor that interacts with bacterial cell wall LPS to initiate an NF-κB-dependent signaling pathway, leading to gene transcription of inflammatory mediators. Increased TLR4 mRNA expression observed in TGF-β1 null mice as well as in mice lacking the TGF-β transcription factor Smad3 was associated with LPS hyperresponsiveness leading to increased expression of inflammatory cytokines and NO and endotoxemia. Furthermore, mice lacking both TGF-β1 and a functional TLR4 were resistant to endotoxin shock. Constitutive and/or environmental activation of TLR4 and downstream elements, in the absence of TGF-β suppression, may impact on innate and adaptive immunity and contribute to massive uncontrolled inflammation.
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TGF-β suppresses the expression and function of TLR4.
“anti-inflammatory cytokine TGF-β suppresses the expression and function of TLR4 [125]”
From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [125]
Cites
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631 · see citing works
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137 · see citing works
NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007 · see citing works
Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,680 · see citing works
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
Arbour, N. C., Lorenz, E., Schutte, B. C., Zabner, J., Kline, J. N., Jones, M., Frees, K., Watt, J. L., & Schwartz, D. A. (2000) · Nature Genetics · doi:10.1038/76048 · Cited by 2,024 · see citing works
Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967 · see citing works
Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 ( Tlr4 )
Qureshi, S. T., Larivière, L., Leveque, G., Clermont, S., Moore, K. J., Gros, P., & Malo, D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.615 · Cited by 1,525 · see citing works
Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2
Aliprantis, A. O., Yang, R., Mark, M. R., Suggett, S., Devaux, B., Radolf, J. D., Klimpel, G. R., Godowski, P. J., & Zychlinsky, A. (1999) · Science · doi:10.1126/science.285.5428.736 · Cited by 1,463 · see citing works
Signal transduction through NF-κB
May, M. J., & Ghosh, S. (1998) · Immunology Today · doi:10.1016/s0167-5699(97)01197-3 · Cited by 1,098 · see citing works
Toll-like Receptor 4 Polymorphisms and Atherogenesis
Kiechl, S. J., Lorenz, E., Reindl, M., Wiedermann, C. J., Oberhollenzer, F., Bonora, E., Willeit, J., & Schwartz, D. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012673 · Cited by 1,024 · see citing works
Gorelik, L., & Flavell, R. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80170-3 · Cited by 959 · see citing works
Yang, X. Y., Letterio, J. J., Lechleider, R. J., Chen, L., Hayman, R., Gu, H., Roberts, A. B., & Deng, C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1280 · Cited by 889 · see citing works
Zhang, G.-L., & Ghosh, S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11837 · Cited by 842 · see citing works
Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock
van Amersfoort, E. S., van Berkel, T. J. C., & Kuiper, J. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.3.379-414.2003 · Cited by 750 · see citing works
The Toll receptor family and microbial recognition.
Medzhitov, R., & Janeway, C. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01845-x · Cited by 739 · see citing works
Relevance of Mutations in the TLR4 Receptor in Patients With Gram-Negative Septic Shock
Lorenz, E., Mira, J. P., Frees, K. L., & Schwartz, D. A. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.9.1028 · Cited by 726 · see citing works
Blocking Smad7 restores TGF-β1 signaling in chronic inflammatory bowel disease
Monteleone, G., Kumberová, A., Croft, N. M., McKenzie, C. A., Steer, H. W., & MacDonald, T. T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12821 · Cited by 602 · see citing works
Toll receptors, CD14, and macrophage activation and deactivation by LPS
Dobrovolskaia, M. A., & Vogel, S. N. (2002) · Microbes and Infection · doi:10.1016/s1286-4579(02)01613-1 · Cited by 565 · see citing works
Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation
Hausmann, M., Kießling, S., Mestermann, S., Webb, G. R., Spöttl, T., Andus, T., Schölmerich, J., Herfarth, H. H., Ray, K., Falk, W., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.33662 · Cited by 488 · see citing works
The IκB/NF-κB system: a key determinant of mucosal inflammation and protection
Jobin, C., & Sartor, R. B. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.3.c451 · Cited by 382 · see citing works
Activation of the transcription factor nuclear factor‐κB in human inflamed synovial tissue
Marok, R., Winyard, P. G., Coumbe, A., Kus, M. L., Gaffney, K., Blades, S., Mapp, P. I., Morris, C. J., Blake, D. R., Kaltschmidt, C., et al. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390407 · Cited by 316 · see citing works
Nuclear factor–kB in rheumatoid synovium. Localization of P50 and P65
Handel, M. L., Mcmorrow, L. B., & Gravallese, E. M. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780381209 · Cited by 289 · see citing works
Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis
Palombella, V. J., Conner, E. M., Fuseler, J. W., Destree, A. T., Davis, J. M., Laroux, F. S., Wolf, R. E., Huang, J., Brand, S., Elliott, P. J., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15671 · Cited by 286 · see citing works
Diebold, R. J., Eis, M. J., Yin, M., Ormsby, I., Boivin, G. P., Darrow, B. J., Saffitz, J. E., & Doetschman, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12215 · Cited by 278 · see citing works
The biology of Toll-like receptors
Means, T. K., Golenbock, D. T., & Fenton, M. J. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00006-x · Cited by 266 · see citing works
Lucas, P. J., Kim, S., Melby, S. J., & Gress, R. E. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.7.1187 · Cited by 244 · see citing works
Letterio, J. J., Geiser, A. G., Kulkarni, A. B., Dang, H., Kong, L., Nakabayashi, T., Mackall, C. L., GRESS, R. E., & Roberts, A. B. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119017 · Cited by 232 · see citing works
Toll-like receptors as potential therapeutic targets for multiple diseases
Zuany‐Amorim, C., Hastewell, J. G., & Walker, C. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd914 · Cited by 231 · see citing works
Kb, H., Im, Y.-H., Parks, W. T., Park, S.-H., Markowitz, S. D., Hy, J., Green, J., & Kim, S.-J. (2001) · Gut · doi:10.1136/gut.49.2.190 · Cited by 196 · see citing works
McCartney-Francis, N. L., Frazier-Jessen, M. R., & Wahl, S. M. (1998) · International Reviews of Immunology · doi:10.3109/08830189809043009 · Cited by 117 · see citing works
Self-citationYoram Vodovotz, B., Geiser, A. G., Chesler, L., Letterio, J. J., Campbell, A., Lucia, M. S., Sporn, M. B., & Roberts, A. B. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.5.2337 · Cited by 112 · see citing works
Dewan, M. Z., Terashima, K., Taruishi, M., Hasegawa, H., Ito, M., Tanaka, Y., Mori, N., Sata, T., Koyanagi, Y., Maeda, M., et al. (2003) · Journal of Virology · doi:10.1128/jvi.77.9.5286-5294.2003 · Cited by 107 · see citing works
Hou, L., Sasaki, H., & Stashenko, P. (2000) · Infection and Immunity · doi:10.1128/iai.68.8.4681-4687.2000 · Cited by 106 · see citing works
Hines, K. L., Kulkarni, A. B., McCarthy, J. B., Tian, H., Ward, J. M., Christ, M., McCartney-Francis, N. L., Furcht, L. T., Karlsson, S., & Wahl, S. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.5187 · Cited by 95 · see citing works
Self-citationFiocchi, C. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13863 · Cited by 91 · see citing works
Qureshi, N., Perera, P., Shen, J., Zhang, G., Lenschat, A., Splitter, G. A., Morrison, D. C., & Vogel, S. N. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.3.1515 · Cited by 90 · see citing works
Inhibition of NF-κB activation in vitro and in vivo: Role of 26S proteasome
Grisham, M. B., Palombella, V. J., Elliott, P. J., Conner, E. M., Brand, S. J., Wong, H. L., Pien, C. S., Mazzola, L. M., Destree, A. T., Parent, L. A., et al. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)00140-8 · Cited by 89 · see citing works
TGF-β: Receptors, Signaling Pathways and Autoimmunity
Chen, W., & Wahl, S. M. (2001) · KARGER eBooks · doi:10.1159/000060548 · Cited by 75 · see citing works
Self-citationMcCartney-Francis, N. L., Mizel, D. E., Redman, R. S., Frazier-Jessen, M. R., Panek, R. B., Kulkarni, A. B., Ward, J. M., McCarthy, J. B., & Wahl, S. M. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.3.1306 · Cited by 62 · see citing works
Self-citationSalkowski, C. A., Thomas, K. E., Cody, M. J., & Vogel, S. N. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.3970 · Cited by 42 · see citing works
Germ-free and barrier-raised TGFβ1-deficient mice have similar inflammatory lesions
Boivin, G. P., Ormsby, I., Jones‐Carson, J., O’Toole, B. A., & Doetschman, T. (1997) · Transgenic Research · doi:10.1023/a:1018490007745 · Cited by 39 · see citing works
Dysregulation of IFN-γ Signaling Pathways in the Absence of TGF-β1
McCartney-Francis, N. L., & Wahl, S. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5941 · Cited by 38 · see citing works
Self-citationLacrimal gland inflammation is responsible for ocular pathology in TGF-beta 1 null mice.
McCartney-Francis, N. L., Mizel, D. E., Frazier-Jessen, M. R., Kulkarni, A. B., McCarthy, J. B., & Wahl, S. M. (1997) · Europe PMC (PubMed Central) · Cited by 38 · see citing works
Self-citation
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Transition from inflammation to proliferation: a critical step during wound healing
Landén, N. X., Li, D., & Ståhle, M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2268-0 · Cited by 1,980 · see citing works
“A plethora of inhibitory mechanisms have been identified in TLR signaling: (i) interference of ligand binding, e.g., soluble forms of TLR2 and TLR4 compete with membrane-bond forms of TLRs for ligands binding; (ii) reduction of TLR expression, e.g., TGF-b suppresses the expression and function of TLR4; (iii) degradati…”
BackgroundInfluentialNegative regulation of Toll-like receptor-mediated immune responses
Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509 · see citing works
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
Thimmulappa, R. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25790 · Cited by 1,028 · see citing works
IL-37 is a fundamental inhibitor of innate immunity
Nold, M. F., Nold‐Petry, C. A., Zepp, J. A., Palmer, B. E., Bufler, P., & Dinarello, C. A. (2010) · Nature Immunology · doi:10.1038/ni.1944 · Cited by 850 · see citing works
Signaling Pathways Downstream of Pattern-Recognition Receptors and Their Cross Talk
Lee, M. S., & Kim, Y. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060605.122847 · Cited by 756 · see citing works
Elson, C. O., Cong, Y., McCracken, V. J., Dimmitt, R. A., Lorenz, R. G., & Weaver, C. T. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00291.x · Cited by 469 · see citing works
Transforming growth factor‐β and Smad signalling in kidney diseases
WANG, W., Koka, V., & Lan, H. Y. (2005) · Nephrology · doi:10.1111/j.1440-1797.2005.00334.x · Cited by 347 · see citing works
Limiting inflammatory responses during activation of innate immunity
Han, J., & Ulevitch, R. J. (2005) · Nature Immunology · doi:10.1038/ni1274 · Cited by 316 · see citing works
New insights into the regulation of TLR signaling
Miggin, S. M., & O'Neill, L. A. J. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1105672 · Cited by 267 · see citing works
Naiki, Y., Michelsen, K. S., Zhang, W., Chen, S., Doherty, T. M., & Arditi, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400503200 · Cited by 183 · see citing works
TGF-β: the perpetrator of immune suppression by regulatory T cells and suicidal T cells
Wahl, S. M., Swisher, J. F. A., McCartney-Francis, N. L., & Chen, W. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.1103539 · Cited by 172 · see citing works
Self-citationCreus, A. D., Abe, M., Lau, A. H., Hackstein, H., Raimondi, G., & Thomson, A. W. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2037 · Cited by 162 · see citing works
Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells
Chen, C., Tsukamoto, H., Liu, J.-C., Kashiwabara, C., Feldman, D. E., Sher, L. S., Dooley, S., French, S. W., Mishra, L., Petrovic, L., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65859 · Cited by 161 · see citing works
RetractedTGF-β-induced IRAK-M expression in tumor-associated macrophages regulates lung tumor growth
Standiford, T. J., Kuick, R., Bhan, U., Chen, J., Newstead, M., & Keshamouni, V. G. (2011) · Oncogene · doi:10.1038/onc.2010.619 · Cited by 151 · see citing works
Lan, Y. Y., Wang, Z., Raimondi, G., Wu, W., Colvin, B. L., Creus, A. D., & Thomson, A. W. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.5868 · Cited by 151 · see citing works
The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling
Moynagh, P. N. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.10.001 · Cited by 142 · see citing works
The negative regulation of Toll‐like receptor and associated pathways
Lang, T., & Mansell, A. S. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100094 · Cited by 133 · see citing works
Choi, K., Lee, Y. S., Lim, S., Choi, H. K., Lee, C., Lee, E., Hong, S., Kim, I.-H., Kim, S., & Park, S. H. (2006) · Nature Immunology · doi:10.1038/ni1383 · Cited by 127 · see citing works
Peroval, M. Y., Boyd, A. C., Young, J. R., & Smith, A. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0051243 · Cited by 122 · see citing works
Lyakh, L. A., Sanford, M. E., Chekol, S., Young, H. A., & Roberts, A. B. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2061 · Cited by 118 · see citing works
Interleukin-37 ameliorates myocardial ischaemia/reperfusion injury in mice
Wu, B., Meng, K., Ji, Q., Cheng, M., Yu, K., Zhao, X., Tony, H., Liu, Y., Zhou, Y., Chang, C. C., et al. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12284 · Cited by 116 · see citing works
Günther, J., Petzl, W., Bauer, I., Ponsuksili, S., Zerbe, H., Schuberth, H., Brunner, R. M., & Seyfert, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-05107-4 · Cited by 106 · see citing works
Genetics of the innate immune response in inflammatory bowel disease
Limbergen, J. V., Russell, R. K., Nimmo, E. R., Ho, G., Arnott, I. D., Wilson, D. C., & Satsangi, J. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20096 · Cited by 88 · see citing works
Toll-Like Receptors in Acute Kidney Injury
Vázquez‐Carballo, C., Guerrero‐Hue, M., García‐Caballero, C., Rayego‐Mateos, S., Opazo-Ríos, L., Morgado‐Pascual, J. L., Herencia, C., Vallejo‐Mudarra, M., Cortegano, I., Gaspar, M.-L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020816 · Cited by 82 · see citing works
Chase, J. C., Celli, J., & Bosio, C. M. (2008) · Infection and Immunity · doi:10.1128/iai.00879-08 · Cited by 82 · see citing works
Modulation of dendritic cell phenotype and functionin an in vitro model of the intestinal epithelium
Butler, M., Ng, C., van Heel, D. A., Lombardi, G., Lechler, R. I., Playford, R. J., & Ghosh, S. K. (2006) · European Journal of Immunology · doi:10.1002/eji.200535497 · Cited by 75 · see citing works
Dampening Ab responses using proteasome inhibitors following in vivo B cell activation
Cascio, P., Oliva, L., Cerruti, F., Mariani, E., Pasqualetto, E., Cenci, S., & Sitia, R. (2008) · European Journal of Immunology · doi:10.1002/eji.200737743 · Cited by 62 · see citing works
Malik, M. Q., Jividen, K., Padmakumar, V. C., Cataisson, C., Li, L., Lee, J., Howard, O. M. Z., & Yuspa, S. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201351109 · Cited by 60 · see citing works
The effect of proteasome inhibitor MG132 on experimental inflammatory bowel disease
Inoue, S., Nakase, H., Matsuura, M., Mikami, S., Ueno, S., Uza, N., & Chiba, T. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03872.x · Cited by 60 · see citing works
Zhang, Y., Liu, S., Liu, J., Zhang, T., Shen, Q., Yu, Y., & Cao, X. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.554 · Cited by 56 · see citing works
Cathepsin K Activity Controls Injury-Related Vascular Repair in Mice
Hu, L., Cheng, X. W., Song, H., Inoue, A., Jiang, H., Li, X., Shi, G., Kozawa, E., Okumura, K., & Kuzuya, M. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02141 · Cited by 52 · see citing works
SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-β1/Smad3 signaling
Liu, X., Zhang, Y., Yu, Y., Yang, X. Y., & Cao, X. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.08.018 · Cited by 49 · see citing works
Ozawa, T., Miyata, M., Nishimura, M., Ando, T., Ouyang, Y., Ohba, T., Shimokawa, N., Ohnuma, Y., Katoh, R., Ogawa, H., et al. (2008) · Journal of Nutrition · doi:10.3945/jn.108.092528 · Cited by 46 · see citing works
Ropert, C., Franklin, B. S., & Gazzinelli, R. T. (2007) · Seminars in Immunopathology · doi:10.1007/s00281-007-0103-2 · Cited by 46 · see citing works
Smad3 Deficiency in Mast Cells Provides Efficient Host Protection against Acute Septic Peritonitis
Kanamaru, Y., Sumiyoshi, K., Ushio, H., Ogawa, H., Okumura, K., & Nakao, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.7.4193 · Cited by 45 · see citing works
Roelofs, M. F., Abdollahi‐Roodsaz, S., Joosten, L. A. B., van den Berg, W. B., & Radstake, T. R. D. J. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23217 · Cited by 44 · see citing works
Chen, Y., Kam, C., Liu, F. Q., Liu, Y., Lui, V. C. H., Lamb, J. R., & Tam, P. K. H. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0807521 · Cited by 43 · see citing works
The proteasome inhibitor MG132 protects against acute pancreatitis
Letoha, T., Somlai, C., Takács, T., Szabolcs, A., Rakonczay, Z., Jármay, K., Szalontai, T., Varga, I., Kaszaki, J., Boros, I., et al. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.06.003 · Cited by 43 · see citing works
Xiao, K., Jiao, L., Cao, S., Song, Z., Hu, C., & Han, X. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114515005085 · Cited by 42 · see citing works
Ding, Y., Peng, Z., Ding, L., & Peng, Y. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00389 · Cited by 41 · see citing works
Hu, Y., Liu, J., Zhu, Y., & Lü, N. (2016) · Helicobacter · doi:10.1111/hel.12292 · Cited by 41 · see citing works
Novel Regulators of the Systemic Response to Lipopolysaccharide
Yang, I. V., Alper, S., Lackford, B. L., Rutledge, H. R., Warg, L. A., Burch, L. H., & Schwartz, D. A. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0342oc · Cited by 40 · see citing works
Basile, M. S., Mazzon, E., Krajnović, T., Drača, D., Cavalli, E., Al‐Abed, Y., Bramanti, P., Nicoletti, F., Mijatović, S., & Maksimović‐Ivanić, D. (2018) · Molecules · doi:10.3390/molecules23102463 · Cited by 39 · see citing works
Kumpf, O., & Schumann, R. (2010) · Journal of Innate Immunity · doi:10.1159/000314269 · Cited by 41 · see citing works
Regulation of TLR expression, a new perspective for the role of VIP in immunity
Gomariz, R. P., Arranz, A., Juarranz, Y., Gutiérrez‐Cañas, I., Garcia-Gomez, M., Leceta, J., & Martínez, C. (2007) · Peptides · doi:10.1016/j.peptides.2007.07.005 · Cited by 38 · see citing works
SMAD4 Is Required for Development of Maximal Endotoxin Tolerance
Pan, H., Ding, E., Hu, M., Lagoo, A. S., Datto, M., & Lagoo‐Deenadayalan, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901601 · Cited by 37 · see citing works
Meyerholz, D. K., Kawashima, K., Gallup, J. M., Grubor, B., & Ackermann, M. R. (2006) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2006.01.001 · Cited by 37 · see citing works
Extracellular Matrix and Growth Factors Improve the Efficacy of Intramuscular Islet Transplantation
Tsuchiya, H., Sakata, N., Yoshimatsu, G., Fukase, M., Aoki, T., Ishida, M., Katayose, Y., Egawa, S., & Unno, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140910 · Cited by 35 · see citing works
Farkas, L., Farkas, D., Warburton, D., Gauldie, J., Shi, W., Stämpfli, M. R., Voelkel, N. F., & Kolb, M. R. J. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00369.2010 · Cited by 33 · see citing works
Qiu, H., Chen, X., Luo, Z., Zhao, L., Zhang, T., Yang, N., Long, X., Xie, H., Liu, J., & Xu, W. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6520 · Cited by 32 · see citing works
Decreased expression of TGF- type II receptor in bronchial glands of smokers with COPD
Baraldo, S. (2005) · Thorax · doi:10.1136/thx.2005.046292 · Cited by 31 · see citing works
Kim, E.-Y., & Kim, B.-C. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.01.044 · Cited by 30 · see citing works
Zhang, W., Wang, X., Xia, X., Liu, X., Suo, S., Guo, J., Li, M., Cao, W., Cai, Z., Hui, Z., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201242697 · Cited by 29 · see citing works
Abdelhamid, A. E., Chuang, S., Hayes, P., & Fell, J. M. E. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31826ee9ec · Cited by 28 · see citing works
Malipiero, U., Koedel, U., Pfister, W., & Fontana, A. (2007) · Neurodegenerative Diseases · doi:10.1159/000100358 · Cited by 26 · see citing works
Impaired Function of Dendritic Cells Deficient in Angiotensin II Type 1 Receptors
Nahmod, K. A., Gentilini, C., Vermeulen, M. E., Uharek, L., Wang, Y., Zhang, J., Schultheiss, H., Geffner, J. R., & Walther, T. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.161760 · Cited by 26 · see citing works
TLR signaling that induces weak inflammatory response and SHIP1 enhances osteogenic functions
Muthukuru, M., & Darveau, R. P. (2014) · Bone Research · doi:10.1038/boneres.2014.31 · Cited by 25 · see citing works
Evren, S., Loai, Y., Antoon, R., Islam, S. S., Yeger, H., Moore, K., Wong, K. K. W., Gorczynski, R. M., & Farhat, W. A. (2010) · Cells Tissues Organs · doi:10.1159/000317332 · Cited by 25 · see citing works
Debrah, A. Y., Debrah, L. B., Albers, A., Mand, S., Toliat, M. R., Nürnberg, P., Adjei, O., Hoerauf, A. M., & Pfarr, K. M. (2011) · Human Immunology · doi:10.1016/j.humimm.2011.07.305 · Cited by 24 · see citing works
CD14 Deficiency Impacts Glucose Homeostasis in Mice through Altered Adrenal Tone
Young, J. L., Mora, A., Cerny, A., Czech, M., Woda, B. A., Kurt‐Jones, E. A., Finberg, R. W., & Corvera, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029688 · Cited by 24 · see citing works
Machida, K., Feldman, D. E., & Tsukamoto, H. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-09614-8_8 · Cited by 23 · see citing works
Al-Kuhlani, M., Rothchild, J., Pal, S., de la Maza, L. M., Ouburg, S., Morré, S. A., Dean, D., & Ojcius, D. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093939 · Cited by 23 · see citing works
Bommireddy, R., Engle, S. J., Ormsby, I., Boivin, G. P., Babcock, G. F., & Doetschman, T. (2004) · Cellular Immunology · doi:10.1016/j.cellimm.2005.02.004 · Cited by 23 · see citing works
Cancer- and cardiac-induced cachexia: same fate through different inflammatory mediators?
Nogueira‐Ferreira, R., Sousa‐Nunes, F., Leite-Moreira, A. F., Moreira‐Costa, L., Vitorino, R. M. P., Santos, L. L., Moreira‐Gonçalves, D., & Ferreira, R. M. (2022) · Inflammation Research · doi:10.1007/s00011-022-01586-y · Cited by 21 · see citing works
GONNELLA, P. A., Waldner, H., del Nido, P. J., & McGowan, F. X. J. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.06.002 · Cited by 20 · see citing works
Bojalil, R., Ruíz-Hernández, A., Villanueva-Arias, A., Amezcua-Guerra, L. M., Cásarez-Alvarado, S., Hernández-Dueñas, A. M. D. R., Rodríguez-Galicia, V., Pavón, L., Marquina, B., Becerril‐Villanueva, E., et al. (2023) · Biological Research · doi:10.1186/s40659-023-00469-8 · Cited by 19 · see citing works
Matsumura, S., Shibakusa, T., Fujikawa, T., Yamada, H., Inoue, K., & Fushiki, T. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.037 · Cited by 18 · see citing works
Aberrant innate immune responses in TLR-ligand activated HLA-B27 transgenic rat cells
Qian, B., Tonkonogy, S. L., & Sartor, R. B. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20502 · Cited by 17 · see citing works
Molecular Regulation of Hepatic Dendritic Cell Function and Its Relation to Liver Transplant Outcome
Sumpter, T. L., Lunz, J. G., Demetris, A. J., & Thomson, A. W. (2009) · Transplantation · doi:10.1097/tp.0b013e3181af7c0d · Cited by 16 · see citing works
Stewart, I. (2005) · The University of Queensland · doi:10.14264/9880 · Cited by 16 · see citing works
Maternal exercise training attenuates endotoxin-induced sepsis in mice offspring
Yamada, M., Hokazono, C., & Okutsu, M. (2018) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2018.06.001 · Cited by 15 · see citing works
Nakayama, T., Illoh, K., Ruetzler, C. A., Auh, S., Sokoloff, L., & Hallenbeck, J. M. (2007) · Brain Research · doi:10.1016/j.brainres.2006.09.116 · Cited by 13 · see citing works
Ma, Y., Lin, J.-P., Lin, J.-X., Hou, J.-F., Xiao, Q., Yu, F., Ma, Z., Li, P., Tu, R., Xie, J., et al. (2020) · Journal of Cancer · doi:10.7150/jca.52299 · Cited by 12 · see citing works
Kassimatis, T. I., Giannopoulou, I., Koumoundourou, D., Theodorakopoulou, E., Varakis, I., & Nakopoulou, L. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00534.x · Cited by 12 · see citing works
Expression and Function of Transforming Growth Factor β in Melioidosis
Weehuizen, T. A. F., Wieland, C. W., van der Windt, G. J. W., Duitman, J., Boon, L., Day, N., Peacock, S. J., van der Poll, T., & Wiersinga, W. J. (2012) · Infection and Immunity · doi:10.1128/iai.05534-11 · Cited by 12 · see citing works
Lv, K., Zhong, Q.-S., Liu, X.-F., Zhu, S., Xiao, S.-C., Wang, G., Ma, B., & Xia, Z. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.11.1090 · Cited by 11 · see citing works
Inoue, T., Ikegame, K., Kaida, K., Okada, M., Yoshihara, S., Tamaki, H., Fujimori, Y., Soma, T., & Ogawa, H. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402950 · Cited by 10 · see citing works
Erbüyün, K., Tok, D., Vatansever, S., Ok, G., Uluer, E. T., Aydede, H., Erhan, Y., & Tekin, İ. (2010) · PubMed · Cited by 9 · see citing works
The study on role of endothelial cell autophagy in rats with sepsis-induced acute kidney injury
Pang, R., Dong, L., Liu, J., Ji, X., Zhuang, H., & Duan, M.-L. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13796 · Cited by 8 · see citing works
Zheng, R., Fu, Z., & Zhao, Z.-M. (2021) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2020.0143 · Cited by 8 · see citing works
Dhaouadi, N., Nehme, A., Faour, W. H., Feugier, P., Cerutti, C., Kacem, K., Eid, A. H., Li, J., & Zibara, K. (2021) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12666 · Cited by 7 · see citing works
Protective properties of human milk.
Goldman, A. S., Goldblum, R. M., Schmalstieg, F. C., Walker, W. A., Watkins, J. B., & Duggan, C. (2003) · Cited by 6 · see citing works
Suppressor αβ T Lymphocytes Control Innate Resistance to Endotoxic Shock
Jones‐Carson, J., Fantuzzi, G., Siegmund, B., Dinarello, C. A., Tracey, K. J., Wang, H., Fang, F. C., & Vázquez‐Torres, A. (2005) · The Journal of Infectious Diseases · doi:10.1086/432727 · Cited by 6 · see citing works
Li, H., Shen, X., Tong, Y., Ji, T., Feng, Y., Tang, Y., Mai, R., Ye, J., Que, T., & Luo, X. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12219 · Cited by 4 · see citing works
The Sympathetic Nervous System Regulates Inflammation in Amoebic Liver Abscess in Hamsters
Ávila‐Blanco, M. E., Muñoz‐Ortega, M. H., Lorenzana, M. G., Quintanar‐Stephano, A., CAMPOS‐ESPARZA, M. R., Campos-Rodriguez, R., & Ventura‐Juárez, J. (2015) · Advances in Neuroimmune Biology · doi:10.3233/nib-150108 · Cited by 3 · see citing works
Kassimatis, T. I., Giannopoulou, I., Koumoundourou, D., Theodorakopoulou, E., Varakis, I., & Nakopoulou, L. (2006) · Journal of Cellular and Molecular Medicine · doi:10.2755/jcmm010.004.05 · Cited by 3 · see citing works
Hepatic Smad4 mediates antibacterial defense via macrophage recruitment
Chen, L., Zhao, W., Wu, Q., Lin, C., Wang, R., Song, Z., Luo, H., Yu, Y., Weiß, G., Min, J., et al. (2026) · Element · doi:10.20517/element.2026.05 · Cited by 1 · see citing works
Buerfent, B. C., Ajendra, J., Stamminger, W., Gondorf, F., Hoerauf, A. M., & Hübner, M. P. (2019) · PubMed Central · doi:10.3205/id000044 · Cited by 1 · see citing works
Krämer, S. (2007) · University writing server of the University of Hohenheim (Universität Hohenheim) · Cited by 1 · see citing works
Functional epithelial cell proteomics under conditions of chronic intestinal inflammation
Shkoda, A. (2007) · mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) · Cited by 1 · see citing works
Lan, Y. Y. (2006) · D-Scholarship@Pitt (University of Pittsburgh)
REGULATORY B CELLS IN THE JEJUNAL PEYER’S PATCHES OF BOVINE AND SHEEP
Jimbo, S. (2014) · University Library - University of Saskatchewan (University of Saskatchewan)
van Keulen, J. K. (2009) · Utrecht University Repository (Utrecht University)
Host-parasite interactions mediated by toll-like receptors in malaria liver infection
França, A. R. S. D. C. (2009) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Participação do Receptor "toll-like"4 na resposta imune durante a esporotricose experimental
Filho, J. D. M., Farmacêuticas, F. D. C., & Araraquara, C. D. (2008)
MAPPIT analysis of the early events in Toll-Like receptor signalling
Ulrichts, P. (2007) · Ghent University Academic Bibliography (Ghent University)
Defining microglial phenotypic diversity and the impact of ageing
Grabert, K. (2015) · ERA
Kassimatis, T. I., Giannopoulou, I., Koumoundourou, D., Theodorakopoulou, E., Varakis, I., & Nakopoulou, L. (2006) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2006.tb00443.x
(2005) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/01.all.0000162314.10050.34
Dendritic Cells Inflammatory Signature Induced by Microbial Pathogens
Foti, M., Beretta, O., Pelizzola, M., & Ricciardi‐Castagnoli, P. (2008) · doi:10.1002/9783527611614.ch19
- Authors
- McCartney-Francis, N., Jin, W., & Wahl, S. M.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Jin, Wenwen
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-03
- Volume
- 172
- Issue
- 6
- Pages
- 3814-3821
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1768438545
- Cited by
- 101
- References
- 43
- Citations by year
- 2026: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 5
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- TGF-β1, TLR4, endotoxemia, NF-κB activation, Smad3, nitric oxide, inflammatory cytokines, innate immunity, uncontrolled inflammation
- MeSH terms
- Animals, Immunity, Innate, Inflammation, Injections, Intraperitoneal, Lipopolysaccharides, Membrane Glycoproteins, Mice, Inbred C3H, Mice, Inbred C57BL, Multiple Organ Failure, Nitric Oxide, Phenotype, Receptors, Cell Surface, Signal Transduction, Up-Regulation, Transforming Growth Factor beta, NF-kappa B, Mice, Knockout, Endotoxemia, Toll-Like Receptors, Toll-Like Receptor 4, Mice, Transforming Growth Factor beta1
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