The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by Interacting with the Poliovirus Receptor (CD155)
Open accessAbstract
The poliovirus receptor (PVR) belongs to a large family of Ig molecules called nectins and nectin-like proteins, which mediate cell-cell adhesion, cell migration, and serve as entry receptors for viruses. It has been recently shown that human NK cells recognize PVR through the receptor DNAM-1, which triggers NK cell stimulation in association with β2 integrin. In this study, we show that NK cells recognize PVR through an additional receptor, CD96, or T cell-activated increased late expression (Tactile). CD96 promotes NK cell adhesion to target cells expressing PVR, stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. Thus, NK cells have evolved a dual receptor system that recognizes nectins and nectin-like molecules on target cells and mediates NK cell adhesion and triggering of effector functions. As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors.
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DNAM-1, A Novel Adhesion Molecule Involved in the Cytolytic Function of T Lymphocytes
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Overexpression of the CD155 gene in human colorectal carcinoma
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Cited by
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
Stanietsky, N., Simic, H., Arapovic, J., Toporik, A., Levy, O., Novik, A., Levine, Z., Beiman, M., Dassa, L., Achdout, H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903474106 · Cited by 3,524
Lanier, L. L. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115526 · Cited by 2,769
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
Cella, M., Fuchs, A., Vermi, W., Facchetti, F., Otero, K., Lennerz, J. K. M., Doherty, J. M., Mills, J. C., & Colonna, M. (2009) · Nature · doi:10.1038/nature07537 · Cited by 1,251
Self-citationTIGIT and PD-1 impair tumor antigen–specific CD8+ T cells in melanoma patients
Chauvin, J.-M., Pagliano, O., Fourcade, J., Sun, Z., Wang, H., Sander, C., Kirkwood, J. M., Chen, T.-H. T., Maurer, M., Korman, A. J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80445 · Cited by 784
Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation
Takai, Y., Miyoshi, J., Ikeda, W., & Ogita, H. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2457 · Cited by 586
Metadata
- Authors
- Fuchs, A., Cella, M., Giurisato, E., Shaw, A. S., & Colonna, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-04-01
- Volume
- 172
- Issue
- 7
- Pages
- 3994-3998
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1634951127
- Cited by
- 358
- References
- 19
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fuchs, A., Cella, M., Giurisato, E., Shaw, A. S., & Colonna, M. (2004). Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by Interacting with the Poliovirus Receptor (CD155). The Journal of Immunology. https://doi.org/10.4049/jimmunol.172.7.3994
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