The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
TCR-Mediated Internalization of Peptide-MHC Complexes Acquired by T Cells
Abstract
Peptide–major histocompatibility complex protein complexes (pMHCs) on antigen-presenting cells (APCs) are central to T cell activation. Within minutes of peptide-specific T cells interacting with APCs, pMHCs on APCs formed clusters at the site of T cell contact. Thereafter, these clusters were acquired by T cells and internalized through T cell receptor–mediated endocytosis. During this process, T cells became sensitive to peptide-specific lysis by neighboring T cells (fratricide). This form of immunoregulation could explain the “exhaustion” of T cell responses that is induced by high viral loads and may serve to down-regulate immune responses.
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Cites
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Cited by
What is trogocytosis and what is its purpose?
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T Cells Compete for Access to Antigen-Bearing Antigen-Presenting Cells
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Metadata
- Authors
- Huang, J.-F., Yang, Y., Sepulveda, H., Shi, W., Hwang, I., Peterson, P. A., Jackson, M. R., Sprent, J., & Cai, Z.
- Venue
- Science
- Published
- 1999-10-29
- Volume
- 286
- Issue
- 5441
- Pages
- 952-954
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2076121010
- Cited by
- 462
- References
- 31
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huang, J.-F., Yang, Y., Sepulveda, H., Shi, W., Hwang, I., Peterson, P. A., Jackson, M. R., Sprent, J., & Cai, Z. (1999). TCR-Mediated Internalization of Peptide-MHC Complexes Acquired by T Cells. Science. https://doi.org/10.1126/science.286.5441.952
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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