The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells
Open accessAbstract
The characteristics and functions of CD4+CD25+ regulatory cells have been well defined in murine and human systems. However, the interaction between CD4+CD25+ T cells and dendritic cells (DC) remains unclear. In this study, we examined the effect of human CD4+CD25+ T cells on maturation and function of monocyte-derived DC. We show that regulatory T cells render the DC inefficient as APCs despite prestimulation with CD40 ligand. This effect was marginally reverted by neutralizing Abs to TGF-β. There was an increased IL-10 secretion and reduced expression of costimulatory molecules in DC. Thus, in addition to direct suppressor effect on CD4+ T cells, regulatory T cells may modulate the immune response through DC.
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Cites
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Cited by
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The PD‐1 pathway in tolerance and autoimmunity
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Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death
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Metadata
- Authors
- Misra, N., Bayry, J., Lacroix-Desmazes, S., Kazatchkine, M. D., & Kaveri, S. V.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-04
- Volume
- 172
- Issue
- 8
- Pages
- 4676-4680
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1962132325
- Cited by
- 477
- References
- 22
- FWCI
- 13.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Misra, N., Bayry, J., Lacroix-Desmazes, S., Kazatchkine, M. D., & Kaveri, S. V. (2004). Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.172.8.4676
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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