The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Two Human ULBP/RAET1 Molecules with Transmembrane Regions Are Ligands for NKG2D
Abstract
We characterized two novel members of the RAET1/ULBP gene cluster, RAET1E and RAET1G. The encoded proteins were similar to the ULBP in their class I-like α1 and α2 domains, but differed in that, instead of being GPI-anchored, their sequences were type 1 membrane-spanning molecules. Both proteins were capable of being expressed at the cell surface. Both proteins bound the activating receptor NKG2D, and RAET1G bound the human CMV protein UL16. The expression of diverse NKG2D-binding molecules in different tissues and with different properties is consistent with multiple modes of infection- or stress-induced activation.
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Cites
Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity
Diefenbach, A., Jensen, E. R., Jamieson, A. M., & Raulet, D. H. (2001) · Nature · doi:10.1038/35093109 · Cited by 1,083
Diefenbach, A., Jamieson, A. M., Liu, S. D., Shastri, N., & Raulet, D. H. (2000) · Nature Immunology · doi:10.1038/77793 · Cited by 878
MICA Engagement by Human Vγ2Vδ2 T Cells Enhances Their Antigen-Dependent Effector Function
Das, H., Groh, V., Kuijl, C., Sugita, M., Morita, C. T., Spies, T., & Bukowski, J. F. (2001) · Immunity · doi:10.1016/s1074-7613(01)00168-6 · Cited by 409 · cited 1×
“ligands may also have a role in the immune response to pathogens, including CMV (15),Mycobacterium tuberculosis (23), andEscherichia coli (24).”
Background
Cited by
Evolutionary struggles between NK cells and viruses
Lanier, L. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2276 · Cited by 451
Promiscuity and the single receptor: NKG2D
Eagle, R. A., & Trowsdale, J. (2007) · Nature Reviews Immunology · doi:10.1038/nri2144 · Cited by 374
Self-citationHedlund, M., Stenqvist, A.-C., Nagaeva, O., Kjellberg, L., Wulff, M., Baranov, V., & Mincheva-Nilsson, L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803477 · Cited by 332
Textor, S., Fiegler, N., Arnold, A., Porgador, A., Hofmann, T. G., & Cerwenka, A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3211 · Cited by 221
McGilvray, R. W., Eagle, R. A., Watson, N. F. S., Al-Attar, A., Ball, G., Jafferji, I., Trowsdale, J., & Durrant, L. G. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0991 · Cited by 196
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Metadata
- Authors
- Bacon, L., Eagle, R. A., Meyer, M., Easom, N., Young, N. T., & Trowsdale, J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07
- Volume
- 173
- Issue
- 2
- Pages
- 1078-1084
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1658020800
- Cited by
- 184
- References
- 3
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bacon, L., Eagle, R. A., Meyer, M., Easom, N., Young, N. T., & Trowsdale, J. (2004). Two Human ULBP/RAET1 Molecules with Transmembrane Regions Are Ligands for NKG2D. The Journal of Immunology. https://doi.org/10.4049/jimmunol.173.2.1078
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