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Murine B7-H3 Is a Negative Regulator of T Cells
Open accessAbstract
T cell activation is regulated by the innate immune system through positive and negative costimulatory molecules. B7-H3 is a novel B7-like molecule with a putative receptor on activated T cells. Human B7-H3 was first described as a positive costimulator, most potently inducing IFN-gamma production and cellular immunity. In this study we examined the expression and function of mouse B7-H3. B7-H3 is mostly expressed on professional APCs; its expression on dendritic cells appears to be up-regulated by LPS. In contrast to human B7-H3, we found that mouse B7-H3 protein inhibited T cell activation and effector cytokine production. An antagonistic mAb to B7-H3 enhanced T cell proliferation in vitro and led to exacerbated experimental autoimmune encephalomyelitis in vivo. Therefore, mouse B7-H3 serves as a negative regulator of T cell activation and function.
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“Interestingly, CD276 (B7-H3), known to augment Tregs and inhibit T cell responses (Costa et al., 2018, Prasad et al., 2004, Suh et al., 2003), was expressed most prominently on CAFs and TSKs.”
From Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma (2020) · cites this paper as Prasad et al., 2004
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1 of the 42 references couldn’t be matched to a known paper.
Research works printed but not linked: 41
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Sorted by citations
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma
Ji, A. L., Rubin, A. J., Thrane, K., Jiang, S., Reynolds, D. L., Meyers, R. M., Guo, M. G., George, B. M., Mollbrink, A., Bergenstråhle, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.039 · Cited by 1,117
“Interestingly, CD276 (B7-H3), known to augment Tregs and inhibit T cell responses (Costa et al., 2018; Prasad et al., 2004; Suh et al., 2003), was expressed most prominently on CAFs and TSKs.”
BackgroundNovel immune checkpoint targets: moving beyond PD-1 and CTLA-4
Qin, S., Xu, L., Yi, M., Yu, S., Wu, K., & Luo, S. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1091-2 · Cited by 1,145
“But recently studies reported that B7-H3 was involved in the inhibition of T cells [121, 122].”
Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy
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“This negative regulation of T cells is associated with diminished NFAT, NF-kB, and AP-1 transcriptional factor activity (16).”
BackgroundInterleukin 25 promotes the initiation of proallergic type 2 responses
Angkasekwinai, P., Park, H., Wang, Y., Wang, Y., Chang, S. H., Corry, D. B., Liu, Y.-J., Zhu, Z., & Dong, C. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061675 · Cited by 558
“Anti–IL-25 mAbs were generated as previously described (25).”
MethodCoinhibitory Pathways in the B7-CD28 Ligand-Receptor Family
Schildberg, F. A., Klein, S. R., Freeman, G. J., & Sharpe, A. H. (2016) · Immunity · doi:10.1016/j.immuni.2016.05.002 · Cited by 560
“B7-H3 is constitutively expressed on murine APCs (Collins et al., 2005), but inducibly expressed on human T cells, NK cells, DCs, macrophages, and monocytes (Chapoval et al., 2001; Prasad et al., 2004; Steinberger et al., 2004; Suh et al., 2003).”
Metadata
- Authors
- Prasad, D. V. R., Nguyen, T., Li, Z., Yang, Y., Duong, J., Wang, Y., & Dong, C.
- Affiliations
- University of Washington (US)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-08
- Volume
- 173
- Issue
- 4
- Pages
- 2500-2506
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2110172571
- Cited by
- 368
- References
- 42
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 30 · 2023: 22 · 2022: 27 · 2021: 34 · 2020: 27 · 2019: 18 · 2018: 10 · 2017: 16 · 2016: 11 · 2015: 11 · 2014: 6 · 2013: 14 · 2012: 17
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- B7-H3, T cell activation, dendritic cells, professional antigen-presenting cells, IFN-gamma production, experimental autoimmune encephalomyelitis, T cell proliferation, mice
- MeSH terms
- Animals, Antigen-Presenting Cells, B-Lymphocytes, Cells, Cultured, Dendritic Cells, Encephalomyelitis, Autoimmune, Experimental, Female, Flow Cytometry, Lymphocyte Activation, Macrophages, T-Lymphocytes, Cytokines, B7-1 Antigen, Antibodies, Blocking, Mice, Rats, B7 Antigens
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