Dong, Chen

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 4,265

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

Yang, X. O., Pappu, B. P., Nurieva, R., Akimzhanov, A., Kang, H. S., Chung, Y., Ma, L., Shah, B., Panopoulos, A. D., Schluns, K. S., et al. (2008) · Immunity

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 1,605

Bcl6 mediates the development of T follicular helper cells

Nurieva, R. I., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka, S., Matskevitch, T. D., Wang, Y.-H., & Dong, C. (2009) · Science

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 1,506

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K., Tian, Q., Watowich, S. S., Jetten, A. M., et al. (2007) · Nature

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 1,466

Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

Nurieva, R. I., Chung, Y., Hwang, D., Yang, X. O., Kang, H. S., Ma, L., Wang, Y.-H., Watowich, S. S., Jetten, A. M., Tian, Q., et al. (2008) · Immunity

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 1,205

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

Chung, Y., Tanaka, S., Chu, F., Nurieva, R. I., Martinez, G. J., Rawal, S., Wang, Y.-H., Lim, H., Reynolds, J. M., Zhou, X.-H., et al. (2011) · Nature Medicine

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 1,120

TH17 cells in development: an updated view of their molecular identity and genetic programming

Dong, C. (2008) · Nature reviews. Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 1,064

Regulation of inflammatory responses by IL-17F

Yang, X. O., Chang, S. H., Park, H., Nurieva, R., Shah, B., Acero, L., Wang, Y.-H., Schluns, K. S., Broaddus, R. R., Zhu, Z., et al. (2008) · The Journal of Experimental Medicine

Psoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

Cited by 739

Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction

Liu, X., Wang, Y., Lu, H., Li, J., Yan, X., Xiao, M., Hao, J., Alekseev, A., Khong, H., Chen, T., et al. (2019) · Nature

T-cell and B-cell ImmunologyNuclear Receptors and Signaling

Cited by 533

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

Xu, T., Stewart, K. M., Wang, X., Liu, K., Xie, M., Ryu, J. K., Li, K., Ma, T., Wang, H., Ni, L., et al. (2017) · Nature

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 395

Murine B7-H3 is a negative regulator of T cells

Prasad, D. V. R., Nguyen, T., Li, Z., Yang, Y., Duong, J., Wang, Y., & Dong, C. (2004) · The Journal of Immunology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 368

Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor

Chang, S. H., Park, H., & Dong, C. (2006) · Journal of Biological Chemistry

NF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions

Cited by 356

Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function

Lee, Y.-H., Martin-Orozco, N., Zheng, P., Li, J., Zhang, P., Tan, H., Park, H. J., Jeong, M., Chang, S. H., Kim, B.-S., et al. (2017) · Cell Research

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 328

The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells

Ichiyama, K., Chen, T., Wang, X., Yan, X., Kim, B.-S., Tanaka, S., Ndiaye-Lobry, D., Deng, Y., Zou, Y., Zheng, P., et al. (2015) · Immunity

Epigenetics and DNA MethylationT-cell and B-cell Immunology

Cited by 327

T helper 17 cells play a critical pathogenic role in lung cancer

Chang, S. H., Mirabolfathinejad, S. G., Katta, H., Cumpian, A. M., Gong, L., Caetano, M. S., Moghaddam, S. J., & Dong, C. (2014) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyImmune cells in cancer

Cited by 326

Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation

Akimzhanov, A. M., Yang, X. O., & Dong, C. (2007) · Journal of Biological Chemistry

Psoriasis: Treatment and PathogenesisGenomics and Chromatin Dynamics

Cited by 302

Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25

Zhong, B., Liu, X., Wang, X., Chang, S. H., Liu, X., Wang, A., Reynolds, J. M., & Dong, C. (2012) · Nature Immunology

Ubiquitin and proteasome pathwaysNF-κB Signaling Pathways

Cited by 206

Impairment of T and B Cell Development by Treatment with a Type I Interferon

Lin, Q., Dong, C., & Cooper, M. D. (1998) · The Journal of Experimental Medicine

T-cell and B-cell Immunologyinterferon and immune responses

Cited by 163

Yin–Yang of costimulation: crucial controls of immune tolerance and function

Nurieva, R. I., Liu, X., & Dong, C. (2009) · Immunological Reviews

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 157

Generation of RORγt+ Antigen-Specific T Regulatory 17 Cells from Foxp3+ Precursors in Autoimmunity

Kim, B.-S., Lu, H., Ichiyama, K., Chen, X., Zhang, Y.-B., Mistry, N. A., Tanaka, K., Lee, Y.-H., Nurieva, R., Zhang, L., et al. (2017) · Cell Reports

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 137

Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation

Reynolds, J. M., Lee, Y.-H., Shi, Y., Wang, X., Angkasekwinai, P., Nallaparaju, K. C., Flaherty, S., Chang, S. H., Watarai, H., & Dong, C. (2015) · Immunity

Psoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

Cited by 135

Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis

Giles, D. A., Moreno-Fernandez, M. E., Stankiewicz, T. E., Cappelletti, M., Huppert, S. S., Iwakura, Y., Dong, C., Shanmukhappa, S. K., & Divanovic, S. (2016) · PLOS ONE

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 116

Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer

Guo, X., Nie, H., Zhang, W., Li, J., Ge, J., Xie, B., Hu, W., Zhu, Y., Zhong, N., Zhang, X., et al. (2025) · Cancer Cell

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 100

Trisomy 21–induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25

Zheng, Q., Li, G., Wang, S., Zhou, Y., Liu, K., Gao, Y., Zhou, Y., Zheng, L., Zhu, L., Deng, Q., et al. (2021) · Science Advances

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 85