The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity
Abstract
Although previous studies have investigated the role of IL-27/WSX-1 interactions in the regulation of Th1 responses, little is known about their role in regulating Th2-type responses. Studies presented in this work identify a direct role for IL-27/WSX-1 interactions in the negative regulation of type 2 responses independent of effects on type 1 cytokines. WSX-1−/− mice infected with the gastrointestinal helminth Trichuris muris displayed accelerated expulsion of parasites and the development of exaggerated goblet cell hyperplasia and mastocytosis in the gut due to increased production of Th2 cytokines. Enhanced mast cell activity in the absence of WSX-1 was consistent with the ability of wild-type mast cells to express this receptor. In addition, IL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites.
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Cites
Tebbutt, N. C., Giraud, A. S., Inglese, M., Jenkins, B., Waring, P., Clay, F. J., Malki, S., Alderman, B. M., Grail, D., Hollande, F., et al. (2002) · Nature Medicine · doi:10.1038/nm763 · Cited by 474
Welte, T., Zhang, S. S. M., Wang, T., Zhang, Z., Hesslein, D. G. T., Yin, Z., Kano, A., Iwamoto, Y., Li, E., Craft, J. E., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0237137100 · Cited by 381
Ernst, M., Inglese, M., Waring, P., Campbell, I. K., Bao, S., Clay, F. J., Alexander, W. S., Wicks, I. P., Tarlinton, D. M., Novak, U., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.2.189 · Cited by 227
Cited by
Stumhofer, J. S., Laurence, A., Wilson, E. H., Huang, E., Tato, C. M., Johnson, L. M., Villarino, A. V., Huang, Q., Yoshimura, A., Sehy, D., et al. (2006) · Nature Immunology · doi:10.1038/ni1376 · Cited by 955
Self-citationNew IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
Hunter, C. A. (2005) · Nature Reviews Immunology · doi:10.1038/nri1648 · Cited by 852
Self-citationType 2 cytokines: mechanisms and therapeutic strategies
Wynn, T. A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3831 · Cited by 678
Owyang, A. M., Zaph, C., Wilson, E. H., Guild, K. J., McClanahan, T., Miller, H. R. P., Cua, D. J., Goldschmidt, M., Hunter, C. A., Kastelein, R. A., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051496 · Cited by 379
Self-citationNotch signaling is an important regulator of type 2 immunity
Tu, L., Fang, T. C., Artis, D., Shestova, O., Pross, S. E., Maillard, I., & Pear, W. S. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050923 · Cited by 284
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Metadata
- Authors
- Artis, D., Villarino, A., Silverman, M., He, W., Thornton, E. M., Mu, S., Summer, S., Covey, T. M., Huang, E., Yoshida, H., Koretzky, G., Goldschmidt, M., Wu, G. D., de Sauvage, F., Miller, H. R. P., Saris, C. J. M., Scott, P., & Hunter, C. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-11-01
- Volume
- 173
- Issue
- 9
- Pages
- 5626-5634
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2110051910
- Cited by
- 245
- References
- 3
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Artis, D., Villarino, A., Silverman, M., He, W., Thornton, E. M., Mu, S., Summer, S., Covey, T. M., Huang, E., Yoshida, H., Koretzky, G., Goldschmidt, M., Wu, G. D., de Sauvage, F., Miller, H. R. P., Saris, C. J. M., Scott, P., & Hunter, C. A. (2004). The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity. The Journal of Immunology. https://doi.org/10.4049/jimmunol.173.9.5626
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
