The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Notch signaling is an important regulator of type 2 immunity
Open accessAbstract
Notch ligands and receptors have been implicated in helper T cell (Th cell) differentiation. Whether Notch signals are involved in differentiation of T helper type 1 (Th1) cells, Th2 cells, or both, however, remains unresolved. To clarify the role of Notch in Th cell differentiation, we generated mice that conditionally inactivate Notch signaling in mature T cells. Mice that lack Notch signaling in CD4+ T cells fail to develop a protective Th2 cell response against the gastrointestinal helminth Trichuris muris. In contrast, they exhibit effective Th1 cell responses and are able to control Leishmania major infection. These data demonstrate that Notch signaling is a regulator of type 2 immunity.
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Cites
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 4,859
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
The lineage decisions of helper T cells
Murphy, K. M., & Reiner, S. L. (2002) · Nature Reviews Immunology · doi:10.1038/nri954 · Cited by 1,674
Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1
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Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination
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Self-citationAmsen, D., Blander, J. M., Lee, G. R., Tanigaki, K., Honjo, T., & Flavell, R. A. (2004) · Cell · doi:10.1016/s0092-8674(04)00451-9 · Cited by 902
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The nervous system and innate immunity: the neuropeptide connection
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REGULATION OF LYMPHOID DEVELOPMENT, DIFFERENTIATION, AND FUNCTION BY THE NOTCH PATHWAY
Maillard, I., Fang, T., & Pear, W. S. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115747 · Cited by 439
Self-citationNotch Activity Influences the αβ versus γδ T Cell Lineage Decision
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Cited by
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
Weng, A. P., Millholland, J. M., Yashiro-Ohtani, Y., Arcangeli, M. L., Lau, A., Wai, C., del Bianco, C., Rodriguez, C. G., Sai, H., Tobias, J., et al. (2006) · Genes & Development · doi:10.1101/gad.1450406 · Cited by 870
Self-citationNotch Signaling in the Immune System
Radtke, F., Fasnacht, N., & MacDonald, H. R. (2010) · Immunity · doi:10.1016/j.immuni.2010.01.004 · Cited by 543
Regulation of innate and adaptive immunity by Notch
Radtke, F., MacDonald, H. R., & Tacchini-Cottier, F. (2013) · Nature Reviews Immunology · doi:10.1038/nri3445 · Cited by 401
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
Amsen, D., Antov, A., Jankovic, D., Sher, A., Radtke, F., Souabni, A., Busslinger, M., McCright, B., Gridley, T., & Flavell, R. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.021 · Cited by 396
Metadata
- Authors
- Tu, L., Fang, T. C., Artis, D., Shestova, O., Pross, S. E., Maillard, I., & Pear, W. S.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2005-10-17
- Volume
- 202
- Issue
- 8
- Pages
- 1037-1042
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2145499731
- Cited by
- 284
- References
- 28
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Tu, L., Fang, T. C., Artis, D., Shestova, O., Pross, S. E., Maillard, I., & Pear, W. S. (2005). Notch signaling is an important regulator of type 2 immunity. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20050923
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