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Cited by 760

The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.

CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells

Open access
Antony, Paul A, Piccirillo, Ciriaco A, Akpinarli, Akgül, Finkelstein, Steven E, Speiss, Paul J, Surman, Deborah R, Palmer, Douglas C, Chan, Chi-Chao, Klebanoff, Christopher A, Overwijk, Willem W, Rosenberg, Steven A, Restifo, Nicholas P·2005·The Journal of Immunology
DOI 10.4049/jimmunol.174.5.2591
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Abstract

CD4+ T cells control the effector function, memory, and maintenance of CD8+ T cells. Paradoxically, we found that absence of CD4+ T cells enhanced adoptive immunotherapy of cancer when using CD8+ T cells directed against a persisting tumor/self-Ag. However, adoptive transfer of CD4+CD25− Th cells (Th cells) with tumor/self-reactive CD8+ T cells and vaccination into CD4+ T cell-deficient hosts induced autoimmunity and regression of established melanoma. Transfer of CD4+ T cells that contained a mixture of Th and CD4+CD25+ T regulatory cells (Treg cells) or Treg cells alone prevented effective adoptive immunotherapy. Maintenance of CD8+ T cell numbers and function was dependent on Th cells that were capable of IL-2 production because therapy failed when Th cells were derived from IL-2−/− mice. These findings reveal that Th cells can help break tolerance to a persisting self-Ag and treat established tumors through an IL-2-dependent mechanism, but requires simultaneous absence of naturally occurring Treg cells to be effective.

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Crossref · 10.4049/jimmunol.174.5.2591

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Metadata

Authors
Antony, P. A., Piccirillo, C. A., Akpinarli, A., Finkelstein, S. E., Speiss, P. J., Surman, D. R., Palmer, D. C., Chan, C.-C., Klebanoff, C. A., Overwijk, W. W., Rosenberg, S. A., & Restifo, N. P.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2005-03-01
Volume
174
Issue
5
Pages
2591-2601
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.174.5.2591
OpenAlex
W2106511557
Cited by
760
References
62
FWCI
20.18
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells. https://app.cochat.ai/papers/10.4049/jimmunol.174.5.2591
The paper
Antony, P. A., Piccirillo, C. A., Akpinarli, A., Finkelstein, S. E., Speiss, P. J., Surman, D. R., Palmer, D. C., Chan, C.-C., Klebanoff, C. A., Overwijk, W. W., Rosenberg, S. A., & Restifo, N. P. (2005). CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells. The Journal of Immunology. https://doi.org/10.4049/jimmunol.174.5.2591

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.