Cited by 2,823Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyCAR-T cell therapy research

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

Dudley, Mark E., Wunderlich, John R., Robbins, Paul F., Yang, James C., Hwu, Patrick, Schwartzentruber, Douglas J., Topalian, Suzanne L., Sherry, Richard +11 more·2002·Science

Abstract

We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen. This approach resulted in the persistent clonal repopulation of T cells in those cancer patients, with the transferred cells proliferating in vivo, displaying functional activity, and trafficking to tumor sites. This led to regression of the patients' metastatic melanoma as well as to the onset of autoimmune melanocyte destruction. This approach presents new possibilities for the treatment of patients with cancer as well as patients with human immunodeficiency virus–related acquired immunodeficiency syndrome and other infectious diseases.

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Registry

Crossref · 10.1126/science.1076514

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28 of 28 references verified0 citation errors · 0 not checkable

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  • Adoptive cell therapy involves genetically modifying T cells to express a chimeric antigen receptor or T cell receptor that recognizes specific antigens displayed on tumors, leading to clinical benefits.

    “Adoptive cell therapy is an immunotherapy that involves genetically modifying T cells to express either a chimeric antigen receptor or T cell receptor (TCR) that can recognize specific antigens displayed on tumors, leading to clinical benefits.602,603”

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Authors
Dudley, M. E., Wunderlich, J. R., Robbins, P. F., Yang, J. C., Hwu, P., Schwartzentruber, D. J., Topalian, S. L., Sherry, R., Restifo, N. P., Hubicki, A. M., Robinson, M. R., Raffeld, M., Duray, P., Seipp, C. A., Rogers-Freezer, L., Morton, K. E., Mavroukakis, S. A., White, D. E., & Rosenberg, S. A.
Affiliations
  • National Cancer Institute (MY)
  • National Eye Institute (US)
  • National Institutes of Health (US)
Corresponding author
Rosenberg, Steven A.
Venue
Science
Published
2002-10-25
Volume
298
Issue
5594
Pages
850-854
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2151246207
Cited by
2,823
References
28
Citations by year
2026: 37 · 2025: 54 · 2024: 55 · 2023: 103 · 2022: 77 · 2021: 91 · 2020: 101 · 2019: 76 · 2018: 92 · 2017: 92 · 2016: 100 · 2015: 118 · 2014: 97 · 2013: 124 · 2012: 116
FWCI
53.37
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (Z99 CA999999)
  • National Cancer Institute (Z01BC010763)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Oncology › CAR-T cell therapy research
Keywords
adoptive T cell therapy, metastatic melanoma, tumor regression, autoimmunity, differentiation antigens, nonmyeloablative conditioning, melanocyte destruction, autoreactive T cells
MeSH terms
Adolescent, Adult, Histocompatibility Antigens Class II, Antigens, Neoplasm, Clone Cells, Female, Humans, Interleukin-2, Lymphocyte Depletion, Male, Melanocytes, Melanoma, Middle Aged, Neoplasm Proteins, T-Lymphocytes, Histocompatibility Antigens Class I, Autoimmunity, HLA-A2 Antigen, Cytokines, Immunotherapy, Adoptive, Lymphocytes, Tumor-Infiltrating, Receptors, Antigen, T-Cell, alpha-beta, Treatment Outcome, CD8-Positive T-Lymphocytes, Lymphocyte Count, MART-1 Antigen

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