Peripheral Deletion of Antigen-Specific T Cells Leads to Long-Term Tolerance Mediated by CD8+ Cytotoxic Cells
Abstract
Peripheral deletion is one mechanism by which potentially self-reactive clones are removed whether they escape thymic deletion. We have examined the consequences of deleting Ag-specific T cells by i.v. injection of soluble Ag. Deletion of DO11.10 T cells by peptide was mediated predominately via a Fas/FasL mechanism. Animals that underwent deletion were tolerant to subsequent immunization with Ag, even when tolerant mice were given fresh Ag-specific DO11.10 T cells before immunization. Tolerance was mediated by CD8+ T cells that killed the DO11.10-transgenic T cells in vivo. These data demonstrate that the programmed cell death of large numbers of T cells leads to peripheral tolerance mediated by CD8+ CTLs.
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DNA damage of transformed cells induces expression of NKG2D ligands, which act on NKG2D expressed by NK cells and CTL.
“DNA damage of transformed cells induces the expression of surface proteins such as natural-killer group 2, member D (NKG2D) ligands, which act on NGK2D expressed by natural killer (NK) cells and CTL31.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [31]
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- Authors
- Herndon, J. M., Stuart, P. M., & Ferguson, T. A.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-04-01
- Volume
- 174
- Issue
- 7
- Pages
- 4098-4104
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2148004846
- Cited by
- 38
- References
- 38
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2018: 2 · 2015: 3 · 2014: 2 · 2012: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ey008972-07)
- National Eye Institute (EY08972, EY 12826, R01EY012707, R01EY012826, EY12707, EY06765)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- peripheral tolerance, CD8+ cytotoxic T lymphocytes, Fas/FasL apoptosis, antigen-specific T cells, soluble antigen, autoreactive T cells, tolerance induction
- MeSH terms
- Animals, Antigens, Immune Tolerance, Immunization, Mice, Inbred BALB C, Spleen, T-Lymphocytes, T-Lymphocytes, Cytotoxic, Apoptosis, Clonal Deletion, CD8-Positive T-Lymphocytes, fas Receptor, T-Cell Antigen Receptor Specificity, Mice
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