The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
IFN-α Enhances TLR3-Mediated Antiviral Cytokine Expression in Human Endothelial and Epithelial Cells by Up-Regulating TLR3 Expression
Open accessAbstract
TLRs play a critical role in early innate immune response to virus infection. TLR3 together with TLR7 and TLR8 constitute a powerful system to detect genetic material of RNA viruses. TLR3 has been shown to bind viral dsRNA whereas TLR7 and TLR8 are receptors for viral single-stranded RNA. In this report we show that TLR7 or TLR8 are not expressed in human epithelial A549 cells or in HUVECs. Accordingly, A549 cells and HUVECs were unresponsive to TLR7/8 ligand R848. TLR3 was expressed at a higher level in HUVECs than in A549 cells. The TLR3 ligand poly(I:C) up-regulated IFN-β, IL-28, IL-29, STAT1, and TLR3 expression in HUVECs but not in A549 cells. An enhanced TLR3 expression by transfection or by IFN-α stimulation conferred poly(I:C) responsiveness in A549 cells. Similarly, IFN-α pretreatment strongly enhanced poly(I:C)-induced activation of IFN-β, IL-28, and IL-29 genes also in HUVECs. In conclusion, our results suggest that IFN-α-induced up-regulation of TLR3 expression is involved in dsRNA activated antiviral response in human epithelial and endothelial cells.
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Cites
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
Cited by
Raison, C. L., Borisov, A. S., Majer, M., Drake, D. F., Pagnoni, G., Woolwine, B. J., Vogt, G. J., Massung, B., & Miller, A. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.010 · Cited by 367
Ospelt, C., Brentano, F., Rengel, Y., Stanczyk, J., Kolling, C., Tak, P. P., Gay, R. E., Gay, S., & Kyburz, D. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24140 · Cited by 351
Cunningham, C., Campion, S., Teeling, J., Felton, L., & Perry, V. H. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.12.007 · Cited by 318
Liu, P., Jamaluddin, M., Li, K., Garofalo, R. P., Casola, A., & Brasier, A. R. (2007) · Journal of Virology · doi:10.1128/jvi.01740-06 · Cited by 320
Guo, Y., Audry, M., Ciancanelli, M., Alsina, L., Azevedo, J., Herman, M., Anguiano, E., Sancho-Shimizu, V., Lorenzo, L., Pauwels, E., et al. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20101568 · Cited by 309
Metadata
- Authors
- Tissari, J., Sirén, J., Meri, S., Julkunen, I., & Matikainen, S.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-04-01
- Volume
- 174
- Issue
- 7
- Pages
- 4289-4294
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2124473438
- Cited by
- 190
- References
- 4
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tissari, J., Sirén, J., Meri, S., Julkunen, I., & Matikainen, S. (2005). IFN-α Enhances TLR3-Mediated Antiviral Cytokine Expression in Human Endothelial and Epithelial Cells by Up-Regulating TLR3 Expression. The Journal of Immunology. https://doi.org/10.4049/jimmunol.174.7.4289
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