The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
In Vivo Depletion of CD11c+ Cells Delays the CD4+ T Cell Response to Mycobacterium tuberculosis and Exacerbates the Outcome of Infection
Abstract
Although dendritic cells (DC) are potent APC that prime T cells against many pathogens, there is no direct evidence that DC are required for immunity to Mycobacterium tuberculosis (Mtb) infection. The requirement for DC to prime the CD4+ T cell response following Mtb infection was investigated using pCD11c-diptheria toxin receptor/GFP transgenic mice, in which DC can be transiently ablated in vivo. We show a critical role for DC in initiation of the CD4+ T cell response to the mycobacterial Ag early secretory Ag of tuberculosis 6. The delay in initiating the Ag-specific T cell response led to impaired control of Mtb replication. Interestingly, DC were not required for the secondary CD4+ T cell response following Mtb infection in peptide-vaccinated mice. Thus, this study shows that DC are essential for the initiation of the adaptive T cell response to the human pathogen Mtb.
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Citations
Cites
Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis
Schaible, U. E., Winau, F., Sieling, P. A., Fischer, K., Collins, H. L., Hagens, K., Modlin, R. L., Brinkmann, V., & Kaufmann, S. H. E. (2003) · Nature Medicine · doi:10.1038/nm906 · Cited by 546
Cited by
Meredith, M. M., Liu, K., Darrasse-Jeze, G., Kamphorst, A. O., Schreiber, H. A., Guermonprez, P., Idoyaga, J., Cheong, C., Yao, K.-H., Niec, R. E., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112675 · Cited by 524
The role of IL-10 in immune regulation during M. tuberculosis infection
Redford, P. S., Murray, P. J., & O'Garra, A. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.7 · Cited by 472
Dendritic cell subsets in primary and secondary T cell responses at body surfaces
Heath, W. R., & Carbone, F. R. (2009) · Nature Immunology · doi:10.1038/ni.1822 · Cited by 421
Immunology of Mycobacterium tuberculosis Infections
Sia, J. K., & Rengarajan, J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0022-2018 · Cited by 312
Metadata
- Authors
- Tian, T., Woodworth, J., Sköld, M., & Behar, S. M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-09-01
- Volume
- 175
- Issue
- 5
- Pages
- 3268-3272
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2130968927
- Cited by
- 175
- References
- 1
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tian, T., Woodworth, J., Sköld, M., & Behar, S. M. (2005). In Vivo Depletion of CD11c+ Cells Delays the CD4+ T Cell Response to Mycobacterium tuberculosis and Exacerbates the Outcome of Infection. The Journal of Immunology. https://doi.org/10.4049/jimmunol.175.5.3268
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
