Cited by 208Immunotherapy and Immune ResponsesHIV Research and TreatmentImmune Response and Inflammation

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Dendritic Cell-Specific Intercellular Adhesion Molecule 3-Grabbing Nonintegrin/CD209 Is Abundant on Macrophages in the Normal Human Lymph Node and Is Not Required for Dendritic Cell Stimulation of the Mixed Leukocyte Reaction

Open access

Granelli-Piperno, Angela, Pritsker, Alla, Pack, Maggi, Shimeliovich, Irina, Arrighi, Jean-Francois, Park, Chae Gyu, Trumpfheller, Christine, Piguet, Vincent, Moran, Thomas M, Steinman, Ralph M·2005·The Journal of Immunology

DOI 10.4049/jimmunol.175.7.4265

Open this paper in CoChat — free account Open PDF

Abstract

The C-type lectin dendritic cell-specific ICAM 3-grabbing nonintegrin (DC-SIGN)/CD209 efficiently binds several pathogens, including HIV-1. DC-SIGN is expressed on monocyte-derived DCs in culture, and importantly, it is able to sequester HIV-1 within cells and facilitate transmission of virus to CD4+ T cells. To investigate DC-SIGN function, we have generated new mAbs. We report in this study that these and prior anti-DC-SIGN mAbs primarily label macrophages in the medullary sinuses of noninflamed human lymph node. In contrast, expression is not detected on most DCs in the T cell area, except for occasional cells. We also noted that IL-4 alone can induce expression of DC-SIGN in CD14+ monocytes and circulating blood DCs. However, blockade of DC-SIGN with Abs and DC-SIGN small interfering RNA did not result in a major reduction in the capacity of these DCs to transfer HIV to T cells, confirming significant DC-SIGN-independent mechanisms. The blocking approaches did reduce HIV-1 transmission by DC-SIGN-transfected cells by >90%. DC-SIGN blockade also did not reduce the ability of DCs to stimulate T cell proliferation in the MLR. These results indicate that DC-SIGN has the potential to contribute to macrophage function in normal human lymph node, and that DCs do not require DC-SIGN to transmit HIV or to initiate T cell responses.

Integrity signals

Registry

Crossref · 10.4049/jimmunol.175.7.4265

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions
McDonald, D., Wu, L., Bohks, S. M., KewalRamani, V. N., Unutmaz, D., & Hope, T. J. (2003) · Science · doi:10.1126/science.1084238 · Cited by 707
DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection
Kwon, D. S., Gregorio, G., Bitton, N., Hendrickson, W. A., & Littman, D. R. (2002) · Immunity · doi:10.1016/s1074-7613(02)00259-5 · Cited by 523 · cited 3×
“After 48 h of IL-4 treatment to stimulate DCSIGN expression, the myeloid DCs were incubated with or without anti-DC-SIGN mAb (AZN-D1), which has previously been shown to block infection via DC-SIGN in monocyte-derived DCs and Raji cells (4, 5).”
BackgroundMethod
DC-SIGN–mediated Infectious Synapse Formation Enhances X4 HIV-1 Transmission from Dendritic Cells to T Cells
Arrighi, J.-F., Pion, M., Garcia, E., Escola, J.-M., van Kooyk, Y., Geijtenbeek, T. B., & Piguet, V. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041356 · Cited by 240
Self-citation

Show all 0 references

Research works printed but not linked: 41

2000, Cell, 575
2003, Nat. Rev. Immunol., 697
1992, Proc. Natl. Acad. Sci. USA, 8356
2000, Cell, 587
2002, Immunity, 135
2003, Int. Immunol., 289
2003, Science, 1295
2004, J. Exp. Med., 1279
2001, J. Virol., 12028
1992, Science, 383
1995, J. Exp. Med., 2045
1995, J. Immunol., 4111
1999, Curr. Biol., 21
2002, J. Virol., 9135
2004, J. Virol., 10848
2003, J. Virol., 12865
2002, Proc. Natl. Acad. Sci. USA, 1568
2002, Nat. Immunol., 975
2002, J. Leukocyte Biol., 445
2004, Int. Immunol., 877
2001, J. Pathol., 586
2002, J. Virol., 1866
2002, AIDS, 683
2004, Am. J. Pathol., 1587
1994, J. Exp. Med., 1109
1994, J. Exp. Med., 83
1992, Biotechnology, 495
1996, J. Virol., 4800
2004, Int. Immunol., 853
2004, Proc. Natl. Acad. Sci. USA, 215
2002, J. Immunol., 2634
2000, Hum. Immunol., 729
2001, J. Exp. Med., 671
2000, J. Immunol., 2937
2000, J. Immunol., 6037
2003, Arthritis Rheum., 360
2005, Nat. Med., 653
2003, J. Exp. Med., 121
2003, J. Leukocyte Biol., 757
2001, Blood, 2482
2003, J. Leukocyte Biol., 710

Sorted by citations

Items 101–190 of 190

Differential Effects of Viral Vectors on Migratory Afferent Lymph Dendritic Cells In Vitro Predict Enhanced Immunogenicity In Vivo
Cubillos-Zapata, C., Guzman, E., Turner, A., Gilbert, S. C., Prentice, H., Hope, J. C., & Charleston, B. (2011) · Journal of Virology · doi:10.1128/jvi.05127-11 · Cited by 40
“DEC-205 is currently the only receptor which has been visualized on most DC in the T cell area of secondary lymphoid tissues, which are the sites for the generation of immunity and tolerance in mouse models and humans (7, 21).”
Background
Preferential Infection of Dendritic Cells during Human Immunodeficiency Virus Type 1 Infection of Blood Leukocytes
Cameron, P. U., Handley, A. J., Baylis, D. C., Solomon, A. E., Bernard, N. J., Purcell, D. F. J., & Lewin, S. R. (2006) · Journal of Virology · doi:10.1128/jvi.01795-06 · Cited by 39
“Further, DC-SIGN is not required for DC–T-cell interactions (22).”
Background
In Vivo Targeting of DC-SIGN-positive Antigen-presenting Cells in a Nonhuman Primate Model
Pereira, C., Torensma, R., Hebeda, K., Kretz-Rommel, A., Faas, S., Figdor, C., & Adema, G. (2007) · Journal of immunotherapy · doi:10.1097/cji.0b013e31812e6256 · Cited by 38
“712 r 2007 Lippincott Williams & Wilkins as a proof-of-principle to show that anti-DC-SIGN antibodies can target a significant number of DC-SIGN molecules in vivo and can reach the LNs. Subsequent in vivo studies can now be designed to determine the immunologic consequences of targeting DC-SIGN in cynomolgus macaques.”
BackgroundResultInfluential
Differences in Anti-Inflammatory Actions of Intravenous Immunoglobulin between Mice and Men: More than Meets the Eye
Tjon, A., van Gent, R., Geijtenbeek, T., & Kwekkeboom, J. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00197 · Cited by 37
DC‐SIGN association with the Th2 environment of lepromatous lesions: cause or effect?
Soilleux, E., Sarno, E., Hernández, M. O., Moseley, E., Horsley, J., Lopes, U., Goddard, M., Vowler, S., Coleman, N., Shattock, R. J., et al. (2006) · Journal of Pathology · doi:10.1002/path.1972 · Cited by 37
“We have previously reported DC-SIGN expression mainly by CD68-positive, S100-positive immature dendritic cells in a wide range of tissues [3], although some subsets of macrophages also express DC-SIGN [5,17,19,20].”
Background
Inhibition of HIV‐1 transmission in trans from dendritic cells to CD4+ T lymphocytes by natural antibodies to the CRD domain of DC‐SIGN purified from breast milk and intravenous immunoglobulins
Requena, M., Bouhlal, H., Nasreddine, N., Saidi, H., Gody, J., Aubry, S., Grésenguet, G., Kazatchkine, M., Sékaly, R., Bélec, L., et al. (2008) · Immunology · doi:10.1111/j.1365-2567.2007.02717.x · Cited by 36
Identification and expression modulation of a C-type lectin domain family 4 homologue that is highly expressed in monocytes/macrophages in rainbow trout (Oncorhynchus mykiss).
Johansson, P., Wang, T.-H., Collet, B., Corripio-Miyar, Y., Monte, M., Secombes, C., & Zou, J. (2016) · Developmental and Comparative Immunology · doi:10.1016/j.dci.2015.08.005 · Cited by 36
“The expression of CD209 has also been studied in tissue macrophages found in oninflamed lymph nodes and in specialized macrophages in the placenta and lung (Bleijs et al., 2001; Soilleux et al., 2002; Granelli-Piperno et al., 2005).”
Background
The multiple facets of HIV attachment to dendritic cell lectins
Tsegaye, T. S., & Pöhlmann, S. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01519.x · Cited by 38
“DC-SIGN is expressed by monocyte-derived dendritic cells (MDDCs) and by dendritic cells in mucosal and lym-phoid tissues, although concerns have been raised that DC-SIGN-positive cells found in some tissues might indeed be macrophages (Granelli-Piperno et al., 2005; Gurney et al., 2005) .”
Background
Dendritic cells: key players in human herpesvirus 8 infection and pathogenesis
Campbell, D. M., Rappocciolo, G., Jenkins, F., & Rinaldo, C. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00452 · Cited by 34
“, and Naresh, K. N. (2010). Follicular dendritic cells in”
BackgroundInfluential
Uterine Epithelial Cell Regulation of DC-SIGN Expression Inhibits Transmitted/Founder HIV-1 Trans Infection by Immature Dendritic Cells
Ochiel, D., Ochsenbauer, C., Kappes, J., Ghosh, M., Fahey, J., & Wira, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014306 · Cited by 34
“HIV-1 trans infection by DC was assayed with a modification of previously described protocols [81,82].”
Method
Selective Transduction of Dendritic Cells in Human Lymph Nodes and Superior Induction of High-avidity Melanoma-reactive Cytotoxic T Cells by a CD40-targeted Adenovirus
Hangalapura, B., Oosterhoff, D., Aggarwal, S., Wijnands, P. G. J. B., van de Ven, R., Santegoets, S., van den Tol, M. P., Hooijberg, E., Pereboev, A., van den Eertwegh, A. V. D., et al. (2010) · Journal of immunotherapy · doi:10.1097/cji.0b013e3181eccbd4 · Cited by 34
The immunotherapeutic potential of dendritic cells in type 1 diabetes
Mukherjee, G., & DiLorenzo, T. P. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04157.x · Cited by 29
Virus entry: old viruses, new receptors
Backovic, M., & Rey, F. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.12.005 · Cited by 32
“The most studied is DC-SIGN (CD209) [9] , which is expressed on myeloid-lineage DCs [10] [11] [12] [13] [14] , in activated B cells [15, 16] and in some macrophages [17, 18] .”
Structural basis for selective recognition of endogenous and microbial polysaccharides by macrophage receptor SIGN-R1.
Silva-Martín, N., Bartual, S. G., Ramírez-Aportela, E., Chacón, P., Park, C., & Hermoso, J. (2014) · Structure · doi:10.1016/j.str.2014.09.001 · Cited by 31
“Whereas human DC-SIGN is expressed in both dendritic cells and macrophages (Geijtenbeek et al., 2000; Granelli-Piperno et al., 2005), the expression of three mouse SIGN homologs is detected in different levels from distinct populations of dendritic cells and macrophages (Cheong et al., 2010; Kang…”
BackgroundSelf-citation
Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus
Martinez, M. G., Bialecki, M. A., Belouzard, S., Cordo, S., Candurra, N., & Whittaker, G. (2013) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2013.10.106 · Cited by 31
“cross react with h-LSIGN [31], only slightly inhibiting infection in hL-SIGN expressing cells that were pre-treated with the same antibody.”
Impact of polymorphisms in the DC-SIGNR neck domain on the interaction with pathogens
Gramberg, T., Zhu, T.-F., Chaipan, C., Marzi, A., Liu, H.-L., Wegele, A., Andrus, T., Hofmann, H., & Pöhlmann, S. (2006) · Virology · doi:10.1016/j.virol.2005.11.033 · Cited by 30
“The C-type (i.e. calcium dependent) lectin DC-SIGN is expressed on dendritic cells (DCs) (Geijtenbeek et al., 2000b (Geijtenbeek et al., , 2000c and certain types of macrophages (Granelli-Piperno et al., 2005; Soilleux et al., 2001 Soilleux et al., , 2002a .”
Background
Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design
Moon, J. H., Phoo, M. T., Kim, Y., Ahn, J., Kim, A., Nam, J., Lee, S., Moon, J. J., & Son, S. (2025) · Advanced Science · doi:10.1002/advs.202509022 · Cited by 32
Professional antigen presenting cells in human herpesvirus 8 infection
Knowlton, E., Lepone, L., Li, J., Rappocciolo, G., Jenkins, F., & Rinaldo, C. (2013) · Front. Immun. · doi:10.3389/fimmu.2012.00427 · Cited by 29
“Besides cellular cytokines and chemokines, HHV-8 encodes several proteins that share homology to host genes.”
Background
CD40-targeted adenoviral cancer vaccines: the long and winding road to the clinic
Hangalapura, B., Timares, L., Oosterhoff, D., Scheper, R. J., Curiel, D. T., & de Gruijl, T. D. (2012) · Journal of Gene Medicine · doi:10.1002/jgm.1648 · Cited by 28
“A case in point is DC-SIGN, with confirmed expression on macrophages in human LNs, despite its often perceived and expounded specificity for DCs [52].”
Background
Sweet Immune Checkpoint Targets to Enhance T Cell Therapy
Derosiers, N., Aguilar, W., Degaramo, D. A., & Posey, A. D. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100706 · Cited by 27
“Dendritic cell specific ICAM-3 grabbing non-integrin (DC- SIGN) is another C-type lectin also expressed on APCs (73, 74), and its interaction with Lewis X Ags on tumor cells leads to immune suppression through various mechanisms driven by TAMs, including increased PD-L1 expression (75, 76).”
Background
Relevance of DC-SIGN in DC-induced T cell proliferation
Gijzen, K., Tacken, P. J., Zimmerman, A. W., Joosten, B., de Vries, I. J. M., Figdor, C. G., & Torensma, R. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0606414 · Cited by 23
“[16], is explained by testing strong MLR”
BackgroundInfluential
The Dermis as a Portal for Dendritic Cell-Targeted Immunotherapy of Cutaneous Melanoma
Oosterhoff, D., Sluijter, B. J. R., Hangalapura, B. N., & de Gruijl, T. D. (2011) · Current topics in microbiology and immunology · doi:10.1007/82_2011_136 · Cited by 18
Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120.
Férir, G., Hänchen, A., François, K., Hoorelbeke, B., Huskens, D., Dettner, F., Süssmuth, R., & Schols, D. (2012) · Virology · doi:10.1016/j.virol.2012.08.007 · Cited by 22
Antibodies and carbohydrate ligands binding to DC‐SIGN differentially modulate receptor trafficking
Tacken, P., ter Huurne, M., Torensma, R., & Figdor, C. (2012) · European Journal of Immunology · doi:10.1002/eji.201142258 · Cited by 22
Interaction between mannosylated lipoarabinomannan and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin influences dendritic cells maturation and T cell immunity.
Wu, T., Guo, S.-L., Wang, J., Li, L., Xu, L.-L., Liu, P., Ma, S.-B., Zhang, J., Xu, L., & Luo, Y.-A. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.09.001 · Cited by 22
Serotype I and II Feline Coronavirus Replication and Gene Expression Patterns of Feline Cells—Building a Better Understanding of Serotype I FIPV Biology
Cook, S., Castillo, D., Williams, S., Haake, C. J. E., & Murphy, B. G. (2022) · Viruses · doi:10.3390/v14071356 · Cited by 19
“This is consistent with the expectation of histiocytic (dendritic cell and macrophage) expression of DC-SIGN [80].”
Result
Kaposi’s Sarcoma-Associated Herpesvirus K3 and K5 Proteins Down Regulate Both DC-SIGN and DC-SIGNR
Lang, S. M., Bynoe, M. O. F., Karki, R., Tartell, M., & Means, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058056 · Cited by 21
“DC-SIGN (dendritic cell-specific ICAM-3 non-grabbing integrin, CD209) is expressed on monocytes, macrophages, dendritic cells (DCs) and activated B cells [23,24,25,26,27,28].”
Background
Receptor-type protein tyrosine phosphatase gamma (PTPgamma), a new identifier for myeloid dendritic cells and specialized macrophages.
Lissandrini, D., Vermi, W., Vezzalini, M., Sozzani, S., Facchetti, F., Bellone, G., Mafficini, A., Gentili, F., Ennas, M., Tecchio, C., et al. (2006) · Blood · doi:10.1182/blood-2006-05-024257 · Cited by 21
Inefficient HIV-1 trans Infection of CD4 + T Cells by Macrophages from HIV-1 Nonprogressors Is Associated with Altered Membrane Cholesterol and DC-SIGN
DeLucia, D. C., Rinaldo, C. R., & Rappocciolo, G. (2018) · Journal of Virology · doi:10.1128/jvi.00092-18 · Cited by 22
Antiviral Properties of Human Milk
Wedekind, S., & Shenker, N. (2021) · Microorganisms · doi:10.3390/microorganisms9040715 · Cited by 19
“HIV viruses interact with the cell surface receptor dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) to enter the cell [49].”
Background
Infectivity and Progression of COVID-19 Based on Selected Host Candidate Gene Variants
Iyer, G. R., Samajder, S., Zubeda, S., Sasikumar, D. S. N., Mali, V., Sharath Krishnan, P. V., Sharma, A., Abbas, N. Z., Bora, N. S., Narravula, A., et al. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00861 · Cited by 23
“The CD209 gene, which encodes the DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin), a key effector of the innate immunity and antiviral defense, is a receptor expressed in the dendritic cells involved in recognition of oligosaccharides present in several pathogens (Granelli-Pipe…”
Background
HIV-1 Transmission by Dendritic Cell-specific ICAM-3-grabbing Nonintegrin (DC-SIGN) Is Regulated by Determinants in the Carbohydrate Recognition Domain That Are Absent in Liver/Lymph Node-SIGN (L-SIGN)
Chung, N. P. Y., Breun, S. K. J., Bashirova, A. A., Baumann, J. G., Martin, T. D., Karamchandani, J. M., Rausch, J. W., Grice, S. F. J. L., Wu, L. J., Carrington, M. N., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.030619 · Cited by 30
Hold on, the monocytes are coming!
Villadangos, J. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.006 · Cited by 18
Olfr2-positive macrophages originate from monocytes proliferate in situ and present a pro-inflammatory foamy-like phenotype.
Suthahar, S. A. A., Nettersheim, F., Alimadadi, A., Wang, E., Billitti, M., Resto-Trujillo, N., Roy, P., Hedrick, C. C., Ley, K., & Orecchioni, M. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae153 · Cited by 17
Expression of the human or porcine C-type lectins DC-SIGN/L-SIGN confers susceptibility to porcine epidemic diarrhea virus entry and infection in otherwise refractory cell lines.
Zhao, P.-W., Xu, L.-D., Zhang, Y., Cao, H.-W., Chen, R., Wang, B., & Huang, Y.-W. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.104956 · Cited by 17
New monoclonal anti-mouse DC-SIGN antibodies reactive with acetone-fixed cells
Cheong, C., de Matos, I. G., Choi, J., Schauer, J. D., Dandamudi, D. B., Shrestha, E., Makeyeva, J. A., Li, X., Li, P., Steinman, R. M., et al. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2010.06.006 · Cited by 16
“It has been reported that human DC-SIGN in vivo is expressed in subpopulations of DCs and macrophages in spleen, lymph nodes, tonsil, skin, intestine, and cervix (Geijtenbeek et al., 2000a,b,c; Soilleux et al., 2001, 2002; Jameson et al., 2002; Ebner et al., 2004; Granelli-Piperno et al., 2005; Pack et al., 2008).”
Self-citation
Characterization of decidual leukocyte populations in cynomolgus and vervet monkeys
Dambaeva, S., Breburda, E., Durning, M., Garthwaite, M., & Golos, T. (2009) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2008.12.006 · Cited by 17
A Versatile Bifunctional Dendritic Cell Targeting Vaccine Vector
Wang, W. W., Das, D., & Suresh, M. R. (2008) · Molecular Pharmaceutics · doi:10.1021/mp800111a · Cited by 17
Expression of DC-SIGN-like C-Type Lectin Receptors in Salmo salar
Ojeda, N., Salazar, C., Cárdenas, C., & Marshall, S. H. (2020) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2020.103806 · Cited by 16
Bovine Derived in vitro Cultures Generate Heterogeneous Populations of Antigen Presenting Cells
Guzman, E., Pujol, M., Ribeca, P., & Montoya, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00612 · Cited by 17
“Previously, several studies have shown that cultures of human blood monocytes with IL4 result in CD209 rapid expression (57, 58) so it is plausible to think that our experimental conditions did not result in the detection of CD209 by flow cytometry at the point of highest expression.”
BackgroundResult
Human thymic dendritic cells: Regulators of T cell development in health and HIV-1 infection
Evans, V. A., Cameron, P. U., & Lewin, S. R. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.08.016 · Cited by 12
Molecular Docking of SP40 Peptide towards Cellular Receptors for Enterovirus 71 (EV-A71)
Masomian, M., Lalani, S., & Poh, C. L. (2021) · Molecules · doi:10.3390/molecules26216576 · Cited by 13
“Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DCSIGN) is a calcium-dependent C-type lectin receptor [61-62] that is expressed in dendritic cells (DCs), macrophages, activated B cells, skin dermis, placenta, intestinal and genital mucosa, and lymphoid tissues [61,63-66].”
Background
Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis
Chen, W., Wu, S.-Y., Lin, T.-C., Lin, S., & Wu‐Hsieh, B. A. (2018) · Cellular and Molecular Immunology · doi:10.1038/s41423-018-0161-5 · Cited by 15
Dendritic Cells in HIV-1 and HCV Infection: Can They Help Win the Battle?
Sehgal, M., Khan, Z. K., Talal, A. H., & Jain, P. (2013) · Virology Research and Treatment · doi:10.4137/vrt.s11046 · Cited by 12
Antiviral therapy for the sexually transmitted viruses: recent updates on vaccine development
Kardani, K., Basimi, P., Fekri, M., & Bolhassani, A. (2020) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2020.1814743 · Cited by 11
HIV-1 trans-Infection Mediated by DCs: The Tip of the Iceberg of Cell-to-Cell Viral Transmission
Perez‐Zsolt, D., Regué, D. R., Muñoz‐Basagoiti, J., Aguilar‐Gurrieri, C., Clotet, B., Blanco, J., & Izquierdo‐Useros, N. (2021) · Pathogens · doi:10.3390/pathogens11010039 · Cited by 18
Characterization of Cells Expressing Lymphatic Marker LYVE-1 in Macaque Large Intestine during Simian Immunodeficiency Virus Infection Identifies A Large Population of Nonvascular LYVE-1+/DC-SIGN+ Cells
Choi, Y., Junecko, B. F. F., Klamar, C. R., & Reinhart, T. (2013) · Lymphatic Research and Biology · doi:10.1089/lrb.2012.0019 · Cited by 10
The Tug-of-War between Dendritic Cells and Human Chronic Viruses
Rahman, S., Khan, Z. K., & Jain, P. (2011) · International Reviews of Immunology · doi:10.3109/08830185.2011.561506 · Cited by 9
“Dendritic cells versus macrophages Macrophages express more DC-SIGN than DCs in the lymphoid tissues and blood [61, 67, 68]”
Background
ICAM-3 influences human immunodeficiency virus type 1 replication in CD4+ T cells independent of DC-SIGN-mediated transmission
Biggins, J. E., Biesinger, T., Kimata, M. T. Y., Arora, R., & Kimata, J. T. (2007) · Virology · doi:10.1016/j.virol.2007.03.017 · Cited by 9
“DC-SIGN is a type II transmembrane lectin binding protein that is expressed on DCs and macrophages (Curtis et al., 1992;Geijtenbeek et al., 2000b;Granelli-Piperno et al., 2005;Satomi et al., 2005).”
BackgroundResult
HIV Impairment of Immune Responses in Dendritic Cells
Ahmed, Z., Czubala, M. A., Blanchet, F. P., & Piguet, V. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4433-6_8 · Cited by 10
Self-citation
Differential modulation of CCR5-tropic human immunodeficiency virus-1 transfer from macrophages towards T cells under interleukin-4/interleukin-13 microenvironment.
Saïdi, H., Carbonneil, C., Magri, G., Eslahpazir, J., Sékaly, R., & Bélec, L. (2010) · Human Immunology · doi:10.1016/j.humimm.2009.08.011 · Cited by 9
Localization of macrophages and dendritic cells in human thoracic lymph nodes: An immunohistochemical study using surgically obtained specimens
Aoki, M., Jin, Z.-W., Ueda, K., Kamimura, G., Takeda-Harada, A., Murakami, G., & Sato, M. (2023) · Journal of Anatomy · doi:10.1111/joa.13870 · Cited by 8
A novel CD209 polymorphism is associated with rheumatoid arthritis patients in Taiwan
Chan, H., Wang, S., Lin, C., Lin, Y., Li, R., & Yen, J. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23751 · Cited by 7
Difference between sentinel and non‐sentinel lymph nodes in the distribution of dendritic cells and macrophages: An immunohistochemical and morphometric study using gastric regional nodes obtained in sentinel node navigation surgery for early gastric cancer
Sonoda, T., Arigami, T., Aoki, M., Matsushita, D., Shimonosono, M., Tsuruda, Y., Sasaki, K., Ohtsuka, T., & Murakami, G. (2024) · Journal of Anatomy · doi:10.1111/joa.14147 · Cited by 7
Binding of the adhesion and pathogen receptor DC-SIGN by monocytes is regulated by the density of Lewis X molecules.
Gijzen, K., Broers, K. M., Beeren, I., Figdor, C., & Torensma, R. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2006.11.015 · Cited by 7
“Mannose glycans as key players in trained immunity: A novel anti-tumoral catalyst”
Almeida, P., Alves, I., Fernandes, Â., Lima, C., Freitas, R., Braga, I. C., Correia, J., Jerónimo, C., & Pinho, S. S. (2025) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2025.130779 · Cited by 8
Changes in phenotypic patterns of blood monocytes after kidney transplantation and during acute rejection.
Švachová, V., Krupičková, L., Novotny, M., Fialová, M., Mezerová, K., Čečrdlova, E., Lánská, V., Slavcev, A., Viklický, O., & Stříž, I. (2021) · Physiological Research · doi:10.33549/physiolres.934700 · Cited by 6
Generation of anti-DC-SIGN monoclonal antibodies capable of blocking HIV-1 gp120 binding and reactive on formalin-fixed tissue.
Canard, B., Vachon, H., Fontaine, T., Pin, J., Paul, S., Genin, C., & Mueller, C. (2011) · Immunology Letters · doi:10.1016/j.imlet.2010.11.002 · Cited by 6
Dendritic cell immunotherapy for HIV infection: from theory to reality.
Oshiro, T., de Almeida, A. D., & Duarte, A. J. D. S. (2009) · Immunotherapy · doi:10.2217/imt.09.68 · Cited by 6
Interactions Between HIV-1 and Innate Immunity in Dendritic Cells
Silvin, A., & Manel, N. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4433-6_7 · Cited by 11
Epitope mapping on the dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) pathogen-attachment factor.
Sierra-Filardi, E., Estecha, A., Samaniego, R., Fernández-Ruiz, E., Colmenares, M., Sánchez-Mateos, P., Steinman, R., Granelli-Piperno, A., & Corbí, Á. (2010) · Molecular Immunology · doi:10.1016/j.molimm.2009.09.036 · Cited by 6
Self-citation
Detection of Fungi by Mannose-based Recognition Receptors
Meyer‐Wentrup, F. A. G., Cambi, A., Figdor, C. G., & Adema, G. J. (2007) · Springer eBooks · doi:10.1007/1-4020-5492-0_13 · Cited by 5
[Recognition of mycobacterial antigens by phagocytes].
Druszczyńska, M., Włodarczyk, M., Fol, M., & Rudnicka, W. (2011) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/17322693.931545 · Cited by 5
“J, van Die I., van Vliet S.J., Vandenbroucke-Grauls C.M., Geijtenbeek T.B., van Kooyk Y.: Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells.”
DC-SIGN in Infection and Immunity
Sprokholt, J., Overmars, R. J., & Geijtenbeek, T. (2016) · Springer eBooks · doi:10.1007/978-4-431-56015-9_9 · Cited by 5
Antitumor immune response elicited by M2 TAM-specific DDS via C-type lectin CD209b using cholesteryl pullulan nanogel as a protein drug carrier
Nakatsukasa, T., Muraoka, D., Deng, S., Yasui, K., Sawada, S., Shimoda, A., Matsushita, H., Matsumoto, K., Nagayasu, T., Harada, N., et al. (2025) · Biomaterials Science · doi:10.1039/d5bm00342c · Cited by 4
Low-frequency CD8+ T cells induced by SIGN-R1+ macrophage-targeted vaccine confer SARS-CoV-2 clearance in mice
Muraoka, D., Meng, L.-M., Muto, O., Nakatsukasa, T., Deng, S.-T., Takashima, C., Yamaguchi, R., Sawada, S.-I., Hayakawa, H., Nguyen, T. T. N., et al. (2024) · npj Vaccines · doi:10.1038/s41541-024-00961-6 · Cited by 4
Intradermal Immunization
Vogt, P. (2012) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-23690-7 · Cited by 4
Identification of dendritic cells in the blood and synovial fluid of children with Juvenile Idiopathic Arthritis.
Tabarkiewicz, J., Postępski, J., Olesińska, E., Roliński, J., & Tuszkiewicz-Misztal, E. (2011) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.2011.0026 · Cited by 4
Simian immunodeficiency Virus Infection Potently Modulates Chemokine Networks and Immune Environments in Hilar Lymph Nodes of Cynomolgus Macaques
Qin, S., Junecko, B. F. F., Lucero, C. M., Klamar, C. R., Trichel, A., Murphey-Corb, M., Tarwater, P., Kirschner, D., & Reinhart, T. (2013) · Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31828ac85f · Cited by 3
Clinical Significance of Nodal DCsign Expression in Non-small-cell Lung Cancer Patients
Aoki, M., Kamimura, G., Morizono, S., Tokunaga, T., Umehara, T., Harada-Takeda, A., Maeda, K., Nagata, T., Ueda, K., Tabata, K., et al. (2023) · Anticancer Research · doi:10.21873/anticanres.16471 · Cited by 2
Antiviral properties of breast milk: a new area of research
Gribakin, S. G., Orlova, S., & Podoprigora, I. (2023) · Medical alphabet · doi:10.33667/2078-5631-2023-8-64-68 · Cited by 2
Vaccines Based on Dendritic Cell Biology
Boscardin, S., Nussenzweig, M., Trumpfheller, C., & Steinman, R. (2016) · doi:10.3109/9781420060744-36 · Cited by 2
Self-citation
Dendritic cell function in HIV infection
Miller, E. A., Bhardwaj, N., & O'Brien, M. (2009) · HIV Therapy · doi:10.2217/hiv.09.34 · Cited by 2
Attachment of human immunodeficiency virus to cells and its inhibition
Pöhlmann, S., & Tremblay, M. J. (2007) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7783-0_3 · Cited by 4
“It was also documented that HIV-1 capture by DCs does either not dependent on DC-SIGN [66, 67] or that the contribution of DC-SIGN is relatively modest with other factors playing an important role [68] [69] [70] [71] .”
BackgroundResultInfluential
Site-dependent differences and common features of lymph node architecture, with special reference to the distribution of nodal dendritic cells and macrophages: a cadaveric study
Miyamoto, E., Aoki, M., Kitamura, K., Sekiya, R., Morita, K., Murakami, G., & Abe, S.-I. (2025) · Anatomy & Cell Biology · doi:10.5115/acb.25.138 · Cited by 1
“DC-SIGN is commonly expressed by nodal DCs and a subpopulation of macrophages [8, 9, 33].”
Lectin-like interactions in virus–cell recognition
Steffen, I., Tsegaye, T. S., & Pöhlmann, S. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374546-0.00028-6 · Cited by 1
“In contrast to this view, Granelli-Piperno and colleagues provided evidence that DC-SIGN-positive cells in normal lymph nodes are almost exclusively of macrophage origin (Granelli-Piperno et al., 2005) .”
BackgroundResult
The requirement for competent antigen presenting dendritic cells and poised T cells for immune responses
Omilusik, K. (2011) · Joint Conference of the Information Retrieval Communities in Europe · doi:10.14288/1.0072079 · Cited by 1
“antibody or DC-SIGN expression was inhibited with small interfering RNA, DCs could still mediate trans- infection [128].”
Major properties of dendritic cells and their actual and potential applications in cancer therapy and infectious disease prophylaxis
Chikileva, I. O., Anisimova, N. Y., Olga, L., Kiselevsky, M. V., & Abramov, V. M. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6931-4_8
Migration of dendritic cell subsets
Sozzani, S., Prete, A. D., Otero, K., Santoro, A., Vermi, W., & Facchetti, F. (2006) · Birkhäuser Basel eBooks · doi:10.1007/3-7643-7442-x_5 · Cited by 1
Macrophage heterogeneity in human secondary lymphoid organs
Segura, É. (2026) · Clinical Science · doi:10.1042/cs20250086
Won’t you be my neighbor? Control of the immune response by stromal and immune cell microenvironments within the lymph node
Harrison, A. G., & Zanoni, I. (2026) · Current Opinion in Immunology · doi:10.1016/j.coi.2026.102787
Finding the Sweet Spot for the Treatment of B Cell Malignancies
Wiersma, V. R. (2025) · Cancers · doi:10.3390/cancers17203366
“Interestingly, DC-SIGN expression on monocytes and macrophages is induced by IL-4 [46,47], a cytokine that is present at high levels in FL and well-known for its tumor-promoting effects [48–50].”
Temporal and spatial characterization of HIV/SIV infection at anorectal mucosa using rhesus macaque rectal challenge modelPreprint
Maric, D., Corbin, L., Greco, N., Lorenzo-Redondo, R., McRaven, M. D., Veazey, R., & Hope, T. (2023) · bioRxiv · doi:10.1101/2023.02.22.529624
“specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) molecule, respectively [35, 36], thus allowing us to group the infected cells into one of the four major categories including Th17 T cells, other T cells, iDCs, and myeloid-like, currently uncharacterized, cells based on overall morphology and e…”
Background
Rôle des polymorphismes dans la région C-Terminale de l'enveloppe du VIH dans l'infection de cellules primaires
da Silva, E. S. (2013) · theses.fr (ABES) · doi:10.70675/571be44cz38c0z432fzb87az66fd4686a457
Développement de glycomimétiques antagonistes du récepteur lectine de type C, DC-SIGN : une nouvelle stratégie préventive anti-HIV
Sutkevičiu̅tė, I. (2012) · theses.fr (ABES) · doi:10.70675/0285a9b5z7649z4316za5eez803884af1c47
Antibodies to the C-type lectin, L-SIGN, as tentative therapeutic agents for induction of antigen-specific tolerance
(2007) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.17.2.243
“For example, DC-SIGN is expressed on macrophages [11,13,14] and has also been detected on SECs [17,43].”
Background
Current World Literature
(2007) · doi:10.1097/mot.0b013e328046d428
Dendritic Cell Targeting Vaccines
Do, Y., & Powell, B. (2015) · doi:10.1007/978-3-662-45024-6_17
“Previously, human DC subsets principally in lymphoid organs were investigated (Granelli-Piperno et al. 2005).”
Background
Molecular and Cellular Pathways Involved in the Anti-inflammatory Activity of IgG
Nimmerjahn, F. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7107-3_5
C-Type Lectins: Multifaceted Receptors in Phagocyte Biology
Cambi, A., & Figdor, C. G. (2014) · ASM Press eBooks · doi:10.1128/9781555816650.ch7

Authors: Granelli-Piperno, A., Pritsker, A., Pack, M., Shimeliovich, I., Arrighi, J.-F., Park, C. G., Trumpfheller, C., Piguet, V., Moran, T. M., & Steinman, R. M.
Affiliations: Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, Rockefeller University , New York, NY 10021
Icahn School of Medicine at Mount Sinai (US)
Rockefeller University (US)
University Hospital of Geneva (CH)
Corresponding author: Pack, Maggi
Shimeliovich, Irina
Trumpfheller, Christine
ORCID: Shimeliovich, Irina
Park, Chae Gyu
Trumpfheller, Christine
Piguet, Vincent
Moran, Thomas M
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2005-10-01
Volume: 175
Issue: 7
Pages: 4265-4273
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.175.7.4265
OpenAlex: W1646818583
Cited by: 208
References: 0
Citations by year: 2026: 2 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 9 · 2013: 15 · 2012: 15
FWCI: 8.18
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Digital Commons - RU (Rockefeller University) (submittedVersion)
YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
Funders: National Institutes of Health (2m01rr000102-41)
National Institute of Allergy and Infectious Diseases (R01 AI40045, 5P30AI42848-04, P30AI042848, R01AI040045)
National Center for Research Resources (M01-RR000102, M0-1 RR00102)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: DC-SIGN, C-type lectin, macrophages, lymph nodes, HIV-1 transmission, dendritic cells, mixed lymphocyte reaction, T cell proliferation, IL-4, monocytes
MeSH terms: DC-Specific ICAM-3 Grabbing Nonintegrin, Animals, Antibodies, Monoclonal, Cell Line, Clone Cells, Dendritic Cells, Dogs, Humans, Lymphocyte Culture Test, Mixed, Lymph Nodes, Macrophages, Mice, Inbred BALB C, Receptors, Cell Surface, Recombinant Proteins, T-Lymphocytes, Transfection, HIV-1, Cell Adhesion Molecules, RNA, Small Interfering, Lectins, C-Type, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dendritic Cell-Specific Intercellular Adhesion Molecule 3-Grabbing Nonintegrin/CD209 Is Abundant on Macrophages in the Normal Human Lymph Node and Is Not Required for Dendritic Cell Stimulation of the Mixed Leukocyte Reaction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks