The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
IL-23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL-23 by Antisense Oligos Increases Dendritic Cell IL-10 Production
Open accessAbstract
IL-23 is a heterodimeric cytokine comprising a p19 subunit associated with the IL-12/23p40 subunit. Like IL-12, IL-23 is expressed predominantly by activated dendritic cells (DCs) and phagocytic cells, and both cytokines induce IFN-γ secretion by T cells. The induction of experimental autoimmune encephalitis, the animal model of multiple sclerosis (MS), occurs in mice lacking IL-12, but not in mice with targeted disruption of IL-23 or both IL-12 and IL-23. Thus, IL-23 expression in DCs may play an important role in the pathogenesis of human autoimmune diseases such as MS. We quantified the expression of IL-23 in monocyte-derived DCs in MS patients and healthy donors and found that DCs from MS patients secrete elevated amounts of IL-23 and express increased levels of IL-23p19 mRNA. Consistent with this abnormality, we found increased IL-17 production by T cells from MS patients. We then transfected monocyte-derived DCs from healthy donors with antisense oligonucleotides specific for the IL-23p19 and IL-12p35 genes and found potent suppression of gene expression and blockade of bioactive IL-23 and IL-12 production without affecting cellular viability or DCs maturation. Inhibition of IL-23 and IL-12 was associated with increased IL-10 and decreased TNF-α production. Furthermore, transfected DCs were poor allostimulators in the MLR. Our results demonstrate that an abnormal Th1 bias in DCs from MS patients related to IL-23 exists, and that antisense oligonucleotides specific to IL-23 can be used for immune modulation by targeting DC gene expression.
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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Cited by
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Interleukin-17 and Type 17 Helper T Cells
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Multiple sclerosis: a complicated picture of autoimmunity
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Dendritic cells and cytokines in human inflammatory and autoimmune diseases
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The pathogenicity of Th17 cells in autoimmune diseases
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Metadata
- Authors
- Vaknin-Dembinsky, A., Balashov, K., & Weiner, H. L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-06
- Volume
- 176
- Issue
- 12
- Pages
- 7768-7774
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1548931116
- Cited by
- 259
- References
- 32
- FWCI
- 18.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vaknin-Dembinsky, A., Balashov, K., & Weiner, H. L. (2006). IL-23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL-23 by Antisense Oligos Increases Dendritic Cell IL-10 Production. The Journal of Immunology. https://doi.org/10.4049/jimmunol.176.12.7768
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