Multiple sclerosis: a complicated picture of autoimmunity

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · see citing works

A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis.

Polman, C., O'Connor, P., Havrdová, E., Hutchinson, M., Kappos, L., Miller, D. H., Phillips, J., Lublin, F., Giovannoni, G., Wajgt, A., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa044397 · Cited by 3,293 · see citing works

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906 · see citing works

Immunology of multiple sclerosis

Sospedra, M., & Martin, R. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115707 · Cited by 2,149 · see citing works

Development, cytokine profile and function of human interleukin 17-producing helper T cells

Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035 · see citing works

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,841 · see citing works

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

Lock, C., Hermans, G., Pedotti, R., Brendolan, A., Schadt, E. E., Garren, H., Langer-Gould, A. M., Strober, S., Cannella, B., Allard, J. D., et al. (2002) · Nature Medicine · doi:10.1038/nm0502-500 · Cited by 1,669 · see citing works

Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology.

Magliozzi, R., Howell, O., Vora, A., Serafini, B., Nicholas, R., Puopolo, M., Reynolds, R., & Aloisi, F. (2007) · Brain : a journal of neurology · doi:10.1093/brain/awm038 · Cited by 1,468 · see citing works

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

Nurieva, R., Yang, X. O., Martinez, G., Zhang, Y., Panopoulos, A. D., Ma, L., Schluns, K., Tian, Q., Watowich, S. S., Jetten, A. M., et al. (2007) · Nature · doi:10.1038/nature05969 · Cited by 1,466 · see citing works

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

Walker, M., Kasprowicz, D. J., Gersuk, V. H., Bénard, A., Landeghen, M. V., Buckner, J. H., & Ziegler, S. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19441 · Cited by 1,242 · see citing works

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

Youssef, S., Stüve, O., Patarroyo, J. C., Ruiz, P. J., Radosevich, J. L., Hur, E. M., Bravo, M., Mitchell, D. J., Sobel, R. A., Steinman, L., et al. (2002) · Nature · doi:10.1038/nature01158 · Cited by 1,098 · see citing works

Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis

Kappos, L., Antel, J. P., Comi, G., Montalbán, X., O'Connor, P. W., Polman, C. H., Haas, T., Korn, A., Karlsson, G., & Radue, E. W. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052643 · Cited by 1,052 · see citing works

The IL-23/IL-17 axis in inflammation

Iwakura, Y. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28508 · Cited by 1,046 · see citing works

Mechanisms of suppression by suppressor T cells

von Boehmer, H. (2005) · Nature Immunology · doi:10.1038/ni1180 · Cited by 1,005 · see citing works

Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

Babbe, H., Roers, A., Waisman, A., Lassmann, H., Goebels, N., Hohlfeld, R., Friese, M., Schröder, R., Deckert, M., Schmidt, S., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.393 · Cited by 951 · see citing works

Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomised, multicentre trial

Hartung, H., Gonsette, R. E., König, N., Kwieciński, H., Guseo, A., Morrissey, S., Krapf, H., & Zwingers, T. (2002) · The Lancet · doi:10.1016/s0140-6736(02)12023-x · Cited by 944 · see citing works

Glutamate excitotoxicity in a model of multiple sclerosis

Pitt, D., Werner, P., & Raine, C. S. (2000) · Nature Medicine · doi:10.1038/71555 · Cited by 855 · see citing works

The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease

Chabas, D., Baranzini, S. E., Mitchell, D., Bernard, C. C. A., Rittling, S. R., Denhardt, D. T., Sobel, R. A., Lock, C., Karpuj, M., Pedotti, R., et al. (2001) · Science · doi:10.1126/science.1062960 · Cited by 829 · cited 1× · see citing works

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand

Bielekova, B., Goodwin, B. L., Richert, N. D., Cortese, I. C. M., Kondo, T., Afshar, G., Gran, B., Eaton, J. K., Antel, J. P., Frank, J. A., et al. (2000) · Nature Medicine · doi:10.1038/80516 · Cited by 823 · see citing works

Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation

Korn, T., Reddy, J., Gao, W., Bettelli, E., Awasthi, A., Petersen, T. R., Bäckström, B. T., Sobel, R. A., Wucherpfennig, K. W., Strom, T. B., et al. (2007) · Nature Medicine · doi:10.1038/nm1564 · Cited by 812 · see citing works

Cutting Edge: CD4+CD25+ Regulatory T Cells Suppress Antigen-Specific Autoreactive Immune Responses and Central Nervous System Inflammation During Active Experimental Autoimmune Encephalomyelitis

Kohm, A. P., Carpentier, P. A., Anger, H. A., & Miller, S. D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4712 · Cited by 782 · see citing works

Recombinant human acid α-glucosidase

Kishnani, P. S., Corzo, D., Nicolino, M. P., Byrne, B. J., Mandel, H., Hwu, W., Leslie, N., Levine, J. E., Spencer, C., McDonald, T. J., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000251268.41188.04 · Cited by 781 · see citing works

Understanding the IL-23–IL-17 immune pathway

McKenzie, B. S., Kastelein, R. A., & Cua, D. J. (2005) · Trends in Immunology · doi:10.1016/j.it.2005.10.003 · Cited by 761 · see citing works

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

Matusevičius, D., Kivisäkk, P., He, B., Kostulas, N., Özenci, V., Fredrikson, S., & Link, H. (1999) · Multiple Sclerosis Journal · doi:10.1177/135245859900500206 · Cited by 751 · see citing works

THE INFLUENCE OF THE PROINFLAMMATORY CYTOKINE, OSTEOPONTIN, ON AUTOIMMUNE DEMYELINATING DISEASE

Chabas, D., Baranzini, S. E., Mitchell, D. J., Bernard, C. C. A., Rittling, S. R., Denhardt, D. T., Sobel, R. A., Lock, C., Karpuj, M. V., Pedotti, R., et al. (2002) · International Conference on Osteopontin and SIBLING Proteins · doi:10.1100/tsw.2002.326 · Cited by 729 · see citing works

Molecular Mimicry, Bystander Activation, or Viral Persistence: Infections and Autoimmune Disease

Fujinami, R. S., von Herrath, M. G., Christen, U., & Whitton, J. L. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.1.80-94.2006 · Cited by 685 · see citing works

Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis

van Walderveen, M. A. A., Kamphorst, W., Scheltens, P., van Waesberghe, J. H. T. M., Ravid, R., Valk, J., Polman, C. H., & Barkhof, F. (1998) · Neurology · doi:10.1212/wnl.50.5.1282 · Cited by 656 · see citing works

Antimyelin Antibodies as a Predictor of Clinically Definite Multiple Sclerosis after a First Demyelinating Event

Berger, T., Rubner, P., Schautzer, F., Egg, R., Ulmer, H., Mayringer, I., Dilitz, E., Deisenhammer, F., & Reindl, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022328 · Cited by 617 · see citing works

Regulatory CD56 bright natural killer cells mediate immunomodulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosis

Bielekova, B., Catálfamo, M., Reichert-Scrivner, S. A., Packer, A., Černá, M., Waldmann, T. A., McFarland, H. F., Henkart, P. A., & Martinꝉ, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601335103 · Cited by 597 · see citing works

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

McRae, B. L., Vanderlugt, C. L., Canto, M. C. D., & Miller, S. D. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.1.75 · Cited by 512 · see citing works

Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients

Muraro, P. A., Douek, D. C., Packer, A., Chung, K., Guenaga, J., Cassiani‐Ingoni, R., Campbell, C., Memon, S. A., Nagle, J. W., Hakim, F. T., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041679 · Cited by 503 · see citing works

Protective and therapeutic role for αB-crystallin in autoimmune demyelination

Ousman, S., Tomooka, B. H., van Noort, J., Wawrousek, E., O'Conner, K., Hafler, D., Sobel, R., Robinson, W., & Steinman, L. (2007) · Nature · doi:10.1038/nature05935 · Cited by 491 · see citing works

Oral simvastatin treatment in relapsing-remitting multiple sclerosis

Vollmer, T. R., Key, L., Durkalski, V., Tyor, W. R., Corboy, J. R., Markovic‐Plese, S., Preiningerova, J. L., Rizzo, M., & Singh, I. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16205-3 · Cited by 471 · see citing works

CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ TH-17 cells in relapsing EAE

Bailey, S. L., Schreiner, B., McMahon, E., & Miller, S. D. (2007) · Nature Immunology · doi:10.1038/ni1430 · Cited by 463 · see citing works

Randomized controlled trial of interferon-beta-1a in secondary progressive MS

Li, D. K. B., Zhao, G., & Paty, D. W. (2001) · Neurology · doi:10.1212/wnl.56.11.1505 · Cited by 458 · see citing works

Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite

Platten, M., Ho, P. P.-K., Youssef, S., da Fontoura, P. P., Garren, H., Hur, E. M., Gupta, R. K., Lee, L. Y., Kidd, B. A., Robinson, W. H., et al. (2005) · Science · doi:10.1126/science.1117634 · Cited by 427 · see citing works

Multiple Sclerosis: Distribution of T Cell Subsets Within Active Chronic Lesions

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Immunologically Active Autoantigens: The Role of Toll-Like Receptors in the Development of Chronic Inflammatory Disease

Marshak‐Rothstein, A., & Rifkin, I. R. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104514 · Cited by 389 · see citing works

Microglial cell activation and proliferation precedes the onset of CNS autoimmunity

Ponomarev, E. D., Shriver, L. P., Maresz, K., & Dittel, B. N. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20488 · Cited by 349 · see citing works

Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9

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Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells

Hur, E.-M., Youssef, S., Haws, M., Zhang, S. Y., Sobel, R. A., & Steinman, L. (2007) · Nature Immunology · doi:10.1038/ni1415 · Cited by 342 · see citing works

IL-1β Regulates Blood-Brain Barrier Permeability via Reactivation of the Hypoxia-Angiogenesis Program

Argaw, A. T., Zhang, Y., Snyder, B., Zhao, M., Kopp, N., Lee, S. C., Raine, C. S., Brosnan, C. F., & John, G. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5574 · Cited by 340 · see citing works

A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor

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Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis

Cepok, S., Zhou, D., Srivastava, R., Nessler, S., Stei, S., Büssow, K., Sommer, N., & Hemmer, B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23661 · Cited by 323 · see citing works

Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis

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Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon β

Bielekova, B., Richert, N. D., Howard, T., Blevins, G., Markovic‐Plese, S., McCartin, J., Wuerfel, J. T., Ohayon, J. M., Waldmann, T. A., McFarland, H. F., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402653101 · Cited by 314 · see citing works

Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate.

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Transection of Major Histocompatibility Complex Class I-Induced Neurites by Cytotoxic T Lymphocytes

Medana, I. M., Martinic, M. M. A., Wekerle, H., & Neumann, H. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61755-5 · Cited by 266 · see citing works

IL-23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL-23 by Antisense Oligos Increases Dendritic Cell IL-10 Production

Vaknin‐Dembinsky, A., Balashov, K. E., & Weiner, H. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.12.7768 · Cited by 257 · see citing works

Lack of Association between Antimyelin Antibodies and Progression to Multiple Sclerosis

Kühle, J., Pohl, C., Mehling, M., Edan, G., Freedman, M. S., Hartung, H., Polman, C. H., Miller, D. H., Montalbán, X., Barkhof, F., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063602 · Cited by 256 · see citing works

Preferential expression and function of Toll-like receptor 3 in human astrocytes

Farina, C., Krumbholz, M., Giese, T., Hartmann, G., Aloisi, F., & Meinl, E. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.09.009 · Cited by 252 · see citing works

High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay

Crawford, M. P., Yan, S. X., Ortega, S. B., Mehta, R. S., Hewitt, R. E., Price, D. A., Šťastný, P., Douek, D. C., Koup, R. A., Racke, M. K., et al. (2004) · Blood · doi:10.1182/blood-2003-11-4025 · Cited by 250 · see citing works

The effect of interferon‐β on blood—brain barrier disruptions demonstrated by constrast‐enhanced magnetic resonance imaging in relapsing—remitting multiple sclerosis

Stone, L. A., Frank, J. A., Albert, P. S., Bash, C. N., Smith, M. E., Maloni, H. W., & McFarland, H. F. (1995) · Annals of Neurology · doi:10.1002/ana.410370511 · Cited by 247 · see citing works

Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4+ T Cells in Multiple Sclerosis

Bielekova, B., Sung, M., Kadom, N., Simon, R. M., McFarland, H. F., & Martinꝉ, R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3893 · Cited by 241 · see citing works

Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis

Sakurai, K., Zou, J.-P., Tschetter, J. R., Ward, J. M., & Shearer, G. M. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00176-5 · Cited by 227 · see citing works

Evolution of T1 black holes in patients with multiple sclerosis imaged monthly for 4 years

Bagnato, F. R. (2003) · Brain · doi:10.1093/brain/awg182 · Cited by 224 · see citing works

Autologous stem cell transplantation for progressive multiple sclerosis: Update of the European Group for Blood and Marrow Transplantation autoimmune diseases working party database

Saccardi, R., Kozák, T., Bocelli‐Tyndall, C., Fassas, Α., Kazis, A., Havrdová, E., Carreras, E., Saiz, A., Löwenberg, B., Boekhorst, P. A. T., et al. (2006) · Multiple Sclerosis Journal · doi:10.1177/1352458506071301 · Cited by 218 · see citing works

Pathologic Role and Temporal Appearance of Newly Emerging Autoepitopes in Relapsing Experimental Autoimmune Encephalomyelitis

Vanderlugt, C. L., Neville, K. L., Nikcevich, K. M., Eagar, T. N., Bluestone, J. A., & Miller, S. D. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.670 · Cited by 213 · see citing works

Therapeutic Induction of Regulatory, Cytotoxic CD8+ T Cells in Multiple Sclerosis

Tennakoon, D. K., Mehta, R. S., Ortega, S. B., Bhoj, V. G., Racke, M. K., & Karandikar, N. J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.7119 · Cited by 207 · see citing works

Pathological abnormalities in the normal-appearing white matter in multiple sclerosis

Allen, I. V., McQuaid, S., Mirakhur, M., & Nevin, G. B. (2001) · Neurological Sciences · doi:10.1007/s100720170012 · Cited by 199 · see citing works

Neuroprotection by Osteopontin in Stroke

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HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis.

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Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia

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Increases in soluble VCAM‐1 correlate with a decrease in MRI lesions in multiple sclerosis treated with interferon β‐1b

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Administration of Neutralizing Antibodies to Interleukin-6 (IL-6) Reduces Experimental Autoimmune Encephalomyelitis and Is Associated with Elevated Levels of IL-6 Bioactivity in Central Nervous System and Circulation

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Prevention of Experimental Autoimmune Encephalomyelitis in Common Marmosets Using an Anti-IL-12p40 Monoclonal Antibody

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Blood‐brain barrier disruption on contrast‐enhanced MRI in patients with mild relapsing‐remitting multiple sclerosis

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Cutting Edge: Alternative Signaling of Th17 Cell Development by Sphingosine 1-Phosphate

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Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details

Moll, N. M., Liu, L., Cardona, A. E., & Ransohoff, R. M. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.09.005 · Cited by 103 · see citing works

Following Anti-CD25 Treatment, A Functional CD4+CD25+ Regulatory T-Cell Pool Is Present in Renal Transplant Recipients

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Serum MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in multiple sclerosis: relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment

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High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis Model1

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Genetics of multiple sclerosis

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Glutamate inhibition in MS: The neuroprotective properties of riluzole

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Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders

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A Suppressive Oligodeoxynucleotide Enhances the Efficacy of Myelin Cocktail/IL-4-Tolerizing DNA Vaccination and Treats Autoimmune Disease

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Experimental Autoimmune Encephalomyelitis Mediated by CD8+ T Cells

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Unique Clinical and Pathological Features in HLA-DRB1*0401–restricted MBP 111–129–specific Humanized TCR Transgenic Mice

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A Pathogenic Role for CD8+ T Cells in a Spontaneous Model of Demyelinating Disease

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Decision letter for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"

(2022) · doi:10.1111/ejn.15817/v2/decision1

Decision letter for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"

(2021) · doi:10.1111/ejn.15817/v1/decision1

Review for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"

(2021) · doi:10.1111/ejn.15817/v1/review2

Review for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"

(2022) · doi:10.1111/ejn.15817/v2/review1

Review for "Astrocytes Show Increased Levels of Ero1α in Multiple Sclerosis (MS) and its Experimental Autoimmune Encephalomyelitis (EAE) Animal Model"

(2022) · doi:10.1111/ejn.15817/v2/review2