The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
DUSP Meet Immunology: Dual Specificity MAPK Phosphatases in Control of the Inflammatory Response
Open accessAbstract
The MAPK family members p38, JNK, and ERK are all activated downstream of innate immunity’s TLR to induce the production of cytokines and inflammatory mediators. However, the relative intensity and duration of the activation of different MAPK appears to determine the type of immune response. The mammalian genome encodes a large number of dual specificity phosphatases (DUSP), many of which act as MAPK phosphatases. In this study, we review the emergence of several DUSP as genes that are differentially expressed and regulated in immune cells. Recently, a series of investigations in mice deficient in DUSP1, DUSP2, or DUSP10 revealed specificity in the regulation of the different MAPK proteins, and defined essential roles in models of local and systemic inflammation. The DUSP family is proposed as a set of molecular control devices specifying and modulating MAPK signaling, which may be targeted to unleash or attenuate innate and adaptive immune effector functions.
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Cites
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Cited by
Dual-specificity phosphatases: critical regulators with diverse cellular targets
Patterson, K. I., Brummer, T., O'brien, P. M., & Daly, R. J. (2009) · Biochemical Journal · doi:10.1042/bj20082234 · Cited by 744
Yao, Z., Torres, N. M., Tao, A., Gao, Y., Luo, L., Li, Q., de Stanchina, E., Abdel-Wahab, O., Solit, D. B., Poulikakos, P. I., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.08.001 · Cited by 543
Obesity accelerates T cell senescence in murine visceral adipose tissue
Shirakawa, K., Yan, X., Shinmura, K., Endo, J., Kataoka, M., Katsumata, Y., Yamamoto, T., Anzai, A., Isobe, S., Yoshida, N., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci88606 · Cited by 271
MAPK signaling in inflammation-associated cancer development
Huang, P., Han, J., & Hui, L. (2010) · Protein & Cell · doi:10.1007/s13238-010-0019-9 · Cited by 273
DUSPs, to MAP kinases and beyond
Huang, C.-Y., & Tan, T.-H. (2012) · Cell & Bioscience · doi:10.1186/2045-3701-2-24 · Cited by 260
Metadata
- Authors
- Lang, R., Hammer, M., & Mages, J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-12-01
- Volume
- 177
- Issue
- 11
- Pages
- 7497-7504
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2153307836
- Cited by
- 331
- References
- 83
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lang, R., Hammer, M., & Mages, J. (2006). DUSP Meet Immunology: Dual Specificity MAPK Phosphatases in Control of the Inflammatory Response. The Journal of Immunology. https://doi.org/10.4049/jimmunol.177.11.7497
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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