The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cutting Edge: Human β Defensin 3—A Novel Antagonist of the HIV-1 Coreceptor CXCR4
Abstract
Previously, we showed that human epithelial cell-derived β-defensins (hBD)-2 and -3 block HIV-1 replication via a direct interaction with virions and through modulation of the CXCR4 coreceptor on immunocompetent cells. In the present study, we show that hBD-3 promotes directly the internalization of CXCR4 yet does not induce calcium flux, ERK (ERK-1/2) phosphorylation, or chemotaxis. hBD-3 competes with stromal-derived factor 1 (SDF-1), the natural ligand for CXCR4, for cellular binding and blocks SDF-1-induced calcium flux, ERK-1/2 phosphorylation, and chemotaxis, without effects on other G protein-coupled receptors. The novel activity of this endogenous CXCR4 antagonist may provide a new strategy for HIV therapies or immunomodulation. Moreover, since the SDF-1/CXCR4 axis plays an important role in hemopoiesis, neurogenesis, cardiogenesis, and angiogenesis, endogenous agents such as hBD-3 or its derivatives offer a new paradigm in immunoregulatory therapeutics and provide the opportunity to enhance future drug design.
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Cites
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809
Crump, M. P., Gong, J., Loetscher, P., Rajarathnam, K., Amara, A., Arenzana‐Seisdedos, F., Virelizier, J., Baggiolini, M., Sykes, B. D., & Clark‐Lewis, I. (1997) · The EMBO Journal · doi:10.1093/emboj/16.23.6996 · Cited by 731 · cited 1×
“Early structure-function analyses of SDF-1 interaction with CXCR4 indicated that N-terminal residues 12 through 17 of SDF-1 are required for selective and high-affinity binding of the chemokine to the N-terminal tail of CXCR4, whereas the extreme N-terminal amino acids (LysPro) of SDF-1 are required for functional act…”
BackgroundLazarini, F., Tham, T. N., Casanova, P., Arenzana‐Seisdedos, F., & Dubois‐Dalcq, M. (2003) · Glia · doi:10.1002/glia.10139 · Cited by 280
Cited by
Bachelerie, F., Ben-Baruch, A., Burkhardt, A. M., Combadiere, C., Farber, J. M., Graham, G. J., Horuk, R., Sparre-Ulrich, A. H., Locati, M., Luster, A. D., et al. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.007724 · Cited by 850
Antimicrobial peptides: General overview and clinical implications in human health and disease
Guaní-Guerra, E., Santos-Mendoza, T., Lugo-Reyes, S. O., & Terán, L. M. (2010) · Clinical Immunology · doi:10.1016/j.clim.2009.12.004 · Cited by 549
Geng, L. N., Yao, Z., Snider, L., Fong, A. P., Cech, J. N., Young, J. M., van der Maarel, S. M., Ruzzo, W. L., Gentleman, R. C., Tawil, R., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.013 · Cited by 458
Metadata
- Authors
- Feng, Z., Dubyak, G. R., Lederman, M. M., & Weinberg, A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-07
- Volume
- 177
- Issue
- 2
- Pages
- 782-786
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2117440442
- Cited by
- 170
- References
- 3
- FWCI
- 6.36
- Type
- journal article
- Language
- en
- Open access
- closed
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- Feng, Z., Dubyak, G. R., Lederman, M. M., & Weinberg, A. (2006). Cutting Edge: Human β Defensin 3—A Novel Antagonist of the HIV-1 Coreceptor CXCR4. The Journal of Immunology. https://doi.org/10.4049/jimmunol.177.2.782
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
