β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

Dendritic cells and the control of immunity

Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,244 · see citing works

Chemokines

Rollins, B. J. (1997) · Blood · doi:10.1182/blood.v90.3.909 · Cited by 1,983 · see citing works

Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites

Dieu‐Nosjean, M., Vanbervliet, B., Vicari, A. P., Bridon, J., Oldham, E., Aït‐Yahia, S., Brière, F., Zlotnik, A., Lebecque, S., & Caux, C. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.373 · Cited by 1,424 · see citing works

A peptide antibiotic from human skin

Harder, J., Bartels, J., Christophers, E., & Schröder, J. ‐. (1997) · Nature · doi:10.1038/43088 · Cited by 1,365 · see citing works

Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis

Goldman, M. J., Anderson, G. M., Stolzenberg, E. D., Kari, U. P., ZASLOFF, M. A., & Wilson, J. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81895-4 · Cited by 1,077 · see citing works

Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid

Smith, J. J., Travis, S. M., Greenberg, E. P., & Welsh, M. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81099-5 · Cited by 1,039 · see citing works

A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration

Falk, W., Goodwin, R. H., & Leonard, E. J. (1980) · Journal of Immunological Methods · doi:10.1016/0022-1759(80)90211-2 · Cited by 942 · see citing works

Plant Defensins: Novel Antimicrobial Peptides as Components of the Host Defense System

Broekaert, W. F., Terras, F. R. G., Cammue, B., & Osborn, R. W. (1995) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.4.1353 · Cited by 765 · see citing works

Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils

Chertov, O., Michiel, D. F., Xu, L., Wang, J., Tani, K., Murphy, W. J., Longo, D. L., Taub, D. D., & Oppenheim, J. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.2935 · Cited by 548 · see citing works

hBD‐1: a novel β‐defensin from human plasma

Bensch, K. W., Raida, M., Mägert, H., Schulz‐Knappe, P., & Forssmann, W. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00687-5 · Cited by 544 · see citing works

Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides

Fehlbaum, P., Bulet, P., Michaut, L., Lagueux, M., Broekaert, W. F., Hétru, C., & Hoffmann, J. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)30111-3 · Cited by 461 · see citing works

Molecular Cloning and Functional Characterization of a Novel Human CC Chemokine Receptor (CCR5) for RANTES, MIP-1β, and MIP-1α

Raport, C. J., Gosling, J., Schweickart, V. L., Gray, P. W., & Charo, I. F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17161 · Cited by 448 · see citing works

Human recombinant monocyte chemotactic protein and other c-c chemokines bind and induce directional migration of dendritic cells in vitro

Xu, L. L., Warren, M. K., Rose, W. L., Gong, W., & Wang, J. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.60.3.365 · Cited by 373 · see citing works

CCR6, a CC Chemokine Receptor that Interacts with Macrophage Inflammatory Protein 3α and Is Highly Expressed in Human Dendritic Cells

Greaves, D. R., Wang, W., Dairaghi, D. J., Dieu‐Nosjean, M., de Saint-Vis, B., Franz-Bacon, K., Rossi, D. L., Caux, C., McClanahan, T. K., Gordon, S., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.6.837 · Cited by 357 · see citing works

Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor

Weissman, D., Rabin, R. L., Arthos, J. A., RUBBERT, A., Dybul, M., Swofford, R., Venkatesan, S., Farber, J. M., & Fauci, A. S. (1997) · Nature · doi:10.1038/40173 · Cited by 347 · see citing works

Defensins

Ganz, T., & Lehrer, R. I. (1994) · Current Opinion in Immunology · doi:10.1016/0952-7915(94)90145-7 · Cited by 337 · see citing works

Chemokine receptors: Structure, function and role in microbial pathogenesis

Murphy, P. M. (1996) · Cytokine & Growth Factor Reviews · doi:10.1016/1359-6101(96)00009-3 · Cited by 320 · see citing works

Mechanisms for induction of acquired host immunity by neutrophil peptide defensins

Lillard, J. W., Boyaka, P. N., Chertov, O., Oppenheim, J. J., & McGhee, J. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.651 · Cited by 305 · see citing works

HIV-1 Tat protein mimicry of chemokines

Albini, A., Ferrini, S., Benelli, R., Sforzini, S., Giunciuglio, D., Aluigi, M. G., Proudfoot, A. E. I., Alouani, S., Wells, T. N. C., Mariani, G., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13153 · Cited by 279 · see citing works

Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells.

Diamond, G., Russell, J. P., & Bevins, C. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.5156 · Cited by 263 · see citing works

Efficient Interaction of HIV-1 with Purified Dendritic Cells via Multiple Chemokine Coreceptors

Granelli‐Piperno, A., Moser, B., Pope, M., Chen, D., Wei, Y., Isdell, F., O’Doherty, U., Paxton, W. A., Koup, R. A., Mojsov, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.6.2433 · Cited by 240 · see citing works

Epithelial antibiotic induced in states of disease

Stolzenberg, E. D., Anderson, G. M., Ackermann, M. R., Whitlock, R. H., & ZASLOFF, M. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8686 · Cited by 219 · see citing works

Identification of Human β-Defensin-2 in Respiratory Tract and Plasma and Its Increase in Bacterial Pneumonia

Hiratsuka, T., Nakazato, M., Date, Y., Ashitani, J.-I., Minematsu, T., Chino, N., & Matsukura, S. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9239 · Cited by 151 · see citing works

Monocyte Chemotactic Protein-3 (MCP3) Interacts with Multiple Leukocyte Receptors

Ben‐Baruch, A., Xu, L., Young, P. R., Bengali, K. M., Oppenheim, J. J., & Wang, J. M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.38.22123 · Cited by 140 · see citing works

Defensins purified from human granulocytes bind C1q and activate the classical complement pathway like the transmenbrane glycoprotein gq41 of HIV-1

Prohászka, Z., ́met, K. N., Csermely, P., Hudecz, F., Mez.o, G., & ̈st, G. F. (1997) · Molecular Immunology · doi:10.1016/s0161-5890(97)00097-7 · Cited by 82 · see citing works

Chemically Synthesized SDF-1α Analogue, N33A, Is a Potent Chemotactic Agent for CXCR4/Fusin/LESTR-expressing Human Leukocytes

Ueda, H., Siani, M. A., Gong, W., Thompson, D. A., Brown, G. G., & Wang, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.24966 · Cited by 63 · see citing works

Book Review

Goldman, M. E. (1997) · Drug Discovery Today · doi:10.1016/s1359-6446(97)84786-1 · Cited by 2 · see citing works

Defensins: antimicrobial peptides of innate immunity

Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066 · see citing works

Points of control in inflammation

Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738 · see citing works

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168 · see citing works

Development, cytokine profile and function of human interleukin 17-producing helper T cells

Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035 · see citing works

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828 · see citing works

International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors

Murphy, P. M., Baggiolini, M., Charo, I. F., Hébert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., & Power, C. A. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01439-x · Cited by 1,817 · see citing works

How dying cells alert the immune system to danger

Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737 · see citing works

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing

Gaffen, S. L., Jain, R., Garg, A. V., & Cua, D. J. (2014) · Nature reviews. Immunology · doi:10.1038/nri3707 · Cited by 1,585 · see citing works

A guide to chemokines and their receptors

Hughes, C. E., & Nibbs, R. J. B. (2018) · FEBS Journal · doi:10.1111/febs.14466 · Cited by 1,424 · see citing works

IL-22 Increases the Innate Immunity of Tissues

Wolk, K., Kunz, S., Witte, E., Friedrich, M., Asadullah, K., & Sabat, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.007 · Cited by 1,362 · see citing works

LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

Krause, A., Neitz, S., Mägert, H.-J., Schulz, A., Forssmann, W.-G., Schulz-Knappe, P., & Adermann, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01920-7 · Cited by 1,324 · see citing works

Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic

Harder, J., Bartels, J., Christophers, E., & Schröder, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008557200 · Cited by 1,309 · see citing works

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

Lai, Y., & Gallo, R. L. (2009) · Trends in Immunology · doi:10.1016/j.it.2008.12.003 · Cited by 1,275 · see citing works

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

Bernhagen, J., Krohn, R. M., Lue, H., Gregory, J. L., Zernecke, A., Koenen, R. R., Dewor, M., Georgiev, I., Schober, A., Leng, L., et al. (2007) · Nature Medicine · doi:10.1038/nm1567 · Cited by 1,272 · see citing works

The Chemokine Superfamily Revisited

Zlotnik, A., & Yoshie, O. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.008 · Cited by 1,239 · see citing works

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

Bevins, C. L., & Salzman, N. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2546 · Cited by 1,238 · see citing works

Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells

Yang, D., Chen, Q., Schmidt, A. P., Anderson, G. M., Wang, J., Wooters, J., Oppenheim, J. J., & Chertov, O. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1069 · Cited by 1,238 · see citing works

Mammalian defensins in the antimicrobial immune response

Selsted, M. E., & Ouellette, A. J. (2005) · Nature Immunology · doi:10.1038/ni1206 · Cited by 1,196 · see citing works

Innate antimicrobial peptide protects the skin from invasive bacterial infection

Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., & Gallo, R. L. (2001) · Nature · doi:10.1038/35106587 · Cited by 1,198 · see citing works

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

Bouskra, D., Brézillon, C., Bérard, M., Werts, C., Varona, R., Boneca, I. G., & Eberl, G. (2008) · Nature · doi:10.1038/nature07450 · Cited by 1,107 · see citing works

Tryptophan- and arginine-rich antimicrobial peptides: Structures and mechanisms of action

Chan, D. I., Prenner, E. J., & Vogel, H. J. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.04.006 · Cited by 1,043 · see citing works

Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis

Conti, H. R., Shen, F., Nayyar, N., Stocum, E., Sun, J. N., Lindemann, M. J., Ho, A. W., Hai, J. H., Yu, J. J., Jung, J. W., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081463 · Cited by 1,024 · see citing works

Type I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases

Banchereau, J., & Pascual, V. (2006) · Immunity · doi:10.1016/j.immuni.2006.08.010 · Cited by 955 · see citing works

Epithelial antimicrobial defence of the skin and intestine

Gallo, R. L., & Hooper, L. V. (2012) · Nature reviews. Immunology · doi:10.1038/nri3228 · Cited by 959 · see citing works

The Inflammatory Response to Cell Death

Rock, K. L., & Kono, H. (2007) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.151456 · Cited by 945 · see citing works

Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2

Biragyn, A., Ruffini, P. A., Leifer, C. A., Klyushnenkova, E., Shakhov, A., Chertov, O., Shirakawa, A., Farber, J. M., Segal, D. M., Oppenheim, J. J., et al. (2002) · Science · doi:10.1126/science.1075565 · Cited by 904 · see citing works

International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors

Bachelerie, F., Ben‐Baruch, A., Burkhardt, A. M., Combadière, C., Farber, J. M., Graham, G. J., Horuk, R., Sparre‐Ulrich, A. H., Locati, M., Luster, A. D., et al. (2013) · Pharmacological Reviews · doi:10.1124/pr.113.007724 · Cited by 846 · see citing works

Alarmins: chemotactic activators of immune responses

Oppenheim, J. J., & Yang, D. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.06.002 · Cited by 780 · see citing works

The CC chemokine CCL20 and its receptor CCR6

Schutyser, E., Struyf, S., & Damme, J. V. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00049-2 · Cited by 777 · see citing works

The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations

Agerberth, B., Charo, J., Werr, J., Olsson, B., Idali, F., Lindbom, L., Kiessling, R., Jörnvall, H., Wigzell, H., & Gudmundsson, G. H. (2000) · Blood · doi:10.1182/blood.v96.9.3086 · Cited by 758 · see citing works

Distinct Dendritic Cell Populations Sequentially Present Antigen to CD4 T Cells and Stimulate Different Aspects of Cell-Mediated Immunity

Itano, A. A., McSorley, S. J., Reinhardt, R. L., Ehst, B. D., Ingulli, E. G., Rudensky, A. Y., & Jenkins, M. K. (2003) · Immunity · doi:10.1016/s1074-7613(03)00175-4 · Cited by 719 · see citing works

The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses

Scott, M. G., Davidson, D. J., Gold, M. R., Bowdish, D. M. E., & Hancock, R. E. W. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3883 · Cited by 713 · see citing works

Mammalian defensins in immunity: more than just microbicidal

Yang, D., Biragyn, A., Kwak, L. W., & Oppenheim, J. J. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02246-9 · Cited by 696 · see citing works

Role of lipids in the interaction of antimicrobial peptides with membranes

Teixeira, V., Feio, M. J., & Bastos, M. (2012) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.12.005 · Cited by 692 · see citing works

Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma

Hammad, H., & Lambrecht, B. N. (2008) · Nature reviews. Immunology · doi:10.1038/nri2275 · Cited by 668 · see citing works

Crohn’s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn’s disease

Brand, S. (2009) · Gut · doi:10.1136/gut.2008.163667 · Cited by 664 · see citing works

Sterile inflammation in the liver

Kubes, P., & Mehal, W. Z. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.09.008 · Cited by 666 · see citing works

Defensins of vertebrate animals

Lehrer, R. I., & Ganz, T. (2002) · Current Opinion in Immunology · doi:10.1016/s0952-7915(01)00303-x · Cited by 662 · see citing works

Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus

Mygind, P. H., Fischer, R. L., Schnorr, K. M., Hansen, M. T., Sönksen, C. P., Ludvigsen, S., Raventós, D., Buskov, S., Christensen, B. B., Maria, L. D., et al. (2005) · Nature · doi:10.1038/nature04051 · Cited by 655 · see citing works

The Roles of Antimicrobial Peptides in Innate Host Defense

Diamond, G., Beckloff, N., Weinberg, A., & Kisich, K. O. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788682325 · Cited by 643 · see citing works

Tissue-Specific Inducible Expression of Antimicrobial Peptide Genes in Drosophila Surface Epithelia

Tzou, P., Ohresser, S., Ferrandon, D., Capovilla, M., Reichhart, J., Lemaître, B., Hoffmann, J. A., & Imler, J. (2000) · Immunity · doi:10.1016/s1074-7613(00)00072-8 · Cited by 613 · see citing works

Macrophage activation by endogenous danger signals

Zhang, X., & Mosser, D. (2007) · The Journal of Pathology · doi:10.1002/path.2284 · Cited by 607 · see citing works

Antimicrobial peptides: an overview of a promising class of therapeutics

Giuliani, A., Pirri, G., & Nicoletto, S. F. (2007) · Open Life Sciences · doi:10.2478/s11535-007-0010-5 · Cited by 609 · see citing works

Benefits and Inputs From Lactic Acid Bacteria and Their Bacteriocins as Alternatives to Antibiotic Growth Promoters During Food-Animal Production

Vieco-Saiz, N., Belguesmia, Y., Raspoet, R., Auclair, E., Gancel, F., Kempf, I., & Drider, D. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00057 · Cited by 606 · see citing works

Innate immunity in the lung: how epithelial cells fight against respiratory pathogens

Bals, R., & Hiemstra, P. S. (2004) · European Respiratory Journal · doi:10.1183/09031936.03.00098803 · Cited by 589 · see citing works

TLR Signaling in the Gut in Health and Disease

Abreu, M. T., Fukata, M., & Arditi, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4453 · Cited by 577 · see citing works

Epithelial crosstalk at the microbiota–mucosal interface

Wells, J. M., Rossi, O., Meijerink, M., & van Baarlen, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000092107 · Cited by 574 · see citing works

Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense

Yang, D., Biragyn, A., Hoover, D. M., Lubkowski, J., & Oppenheim, J. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104603 · Cited by 572 · see citing works

Programming the Assembly of Two- and Three-Dimensional Architectures with DNA and Nanoscale Inorganic Building Blocks,

Mirkin, C. A. (2000) · Inorganic Chemistry · doi:10.1021/ic991123r · Cited by 562 · see citing works

The Concise Guide to PHARMACOLOGY 2013/14: G Protein‐Coupled Receptors

Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12445 · Cited by 555 · see citing works

Probiotics, Prebiotics and Immunomodulation of Gut Mucosal Defences: Homeostasis and Immunopathology

Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. (2013) · Nutrients · doi:10.3390/nu5061869 · Cited by 551 · see citing works

Antimicrobial peptides: General overview and clinical implications in human health and disease

Guaní-Guerra, E., Santos-Mendoza, T., Reyes, S. O. L., & Teran, L. M. (2010) · Clinical Immunology · doi:10.1016/j.clim.2009.12.004 · Cited by 548 · see citing works

Antimicrobial Peptides Human β-Defensins Stimulate Epidermal Keratinocyte Migration, Proliferation and Production of Proinflammatory Cytokines and Chemokines

Niyonsaba, F., Ushio, H., Nakano, N., Ng, W., Sayama, K., Hashimoto, K., Nagaoka, I., Okumura, K., & Ogawa, H. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700599 · Cited by 544 · see citing works

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses

Lowes, M. A., Russell, C. B., Martin, D. A., Towne, J. E., & Krueger, J. G. (2013) · Trends in Immunology · doi:10.1016/j.it.2012.11.005 · Cited by 538 · see citing works

Up-Regulation of Macrophage Inflammatory Protein-3α/CCL20 and CC Chemokine Receptor 6 in Psoriasis

Homey, B., Dieu‐Nosjean, M., Wiesenborn, A., Massacrier, C., Pin, J., Oldham, E. R., Catron, D., Buchanan, M. E., Müller, A., Malefyt, R. D. W., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6621 · Cited by 537 · see citing works

Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes

Pène, J., Chevalier, S., Preisser, L., Vénéreau, E., Guilleux, M.-H., Ghannam, S., Molès, J., Danger, Y., Ravon, E., Saux, S. L., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7423 · Cited by 529 · see citing works

Structure and function of the epidermis related to barrier properties

Baroni, A., Buommino, E., Gregorio, V. D., Ruocco, E., Ruocco, V., & Wolf, R. (2012) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2011.08.007 · Cited by 530 · see citing works

Innate and adaptive immunity in female genital tract: cellular responses and interactions

Wira, C. R., Fahey, J. V., Sentman, C. L., Pioli, P. A., & Shen, L. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00287.x · Cited by 523 · see citing works

Human β-defensins

Pazgier, M., Hoover, D. M., Yang, D., Lu, W., & Lubkowski, J. T. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5540-2 · Cited by 514 · see citing works

Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

Yang, D., Chen, Q., Chertov, O., & Oppenheim, J. J. (2000) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.1.9 · Cited by 501 · see citing works

Epithelial antimicrobial peptides in host defense against infection

Bals, R. (2000) · Respiratory Research · doi:10.1186/rr25 · Cited by 499 · see citing works

Host defense peptides: front-line immunomodulators

Mansour, S., Pena, O. M., & Hancock, R. E. W. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.07.004 · Cited by 493 · see citing works

Discovery of five conserved β-defensin gene clusters using a computational search strategy

Schutte, B. C., Mitros, J., Bartlett, J. A., Walters, J. D., Jia, H. P., Welsh, M. J., Casavant, T. L., & McCray, P. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042692699 · Cited by 488 · see citing works

NF-κB- and AP-1-Mediated Induction of Human Beta Defensin-2 in Intestinal Epithelial Cells byEscherichia coliNissle 1917: a Novel Effect of a Probiotic Bacterium

Wehkamp, J., Harder, J., Wehkamp, K., Meissner, B. W.-V., Schlee, M., Enders, C., Sonnenborn, U., Nuding, S., Bengmark, S., Fellermann, K., et al. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.5750-5758.2004 · Cited by 471 · see citing works

Defensins in innate antiviral immunity

Klotman, M. E., & Chang, T. L. (2006) · Nature Reviews Immunology · doi:10.1038/nri1860 · Cited by 471 · see citing works

Human β‐defensin 4: a novel inducible peptide with a specific salt‐sensitive spectrum of antimicrobial activity

Conejo-Garcia, J. R., Krause, A., Schulz, S., Rodríguez-Jiménez, F. J., Klüver, E., Adermann, K., Forssmann, U., Frimpong‐Boateng, A., Bals, R., & Forssmann, W. (2001) · The FASEB Journal · doi:10.1096/fj.00-0865fje · Cited by 469 · see citing works

Cationic host defence peptides: Innate immune regulatory peptides as a novel approach for treating infections

Mookherjee, N., & Hancock, R. E. W. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6475-6 · Cited by 465 · see citing works

Many chemokines including CCL20/MIP-3α display antimicrobial activity

Yang, D., Chen, Q., Hoover, D. M., Staley, P. G., Tucker, K. D., Lubkowski, J. T., & Oppenheim, J. J. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0103024 · Cited by 464 · see citing works

DUX4 Activates Germline Genes, Retroelements, and Immune Mediators: Implications for Facioscapulohumeral Dystrophy

Geng, L. N., Yao, Z., Snider, L. D., Fong, A. P., Cech, J. N., Young, J. M., van der Maarel, S. M., Ruzzo, W. L., Gentleman, R. C., Tawil, R., et al. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.11.013 · Cited by 459 · see citing works

Innate Immunity in the Respiratory Epithelium

Parker, D., & Prince, A. S. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0011rt · Cited by 454 · see citing works

Primate defensins

Lehrer, R. I. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro976 · Cited by 455 · see citing works

Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human β-defensin 3

Wu, Z., Hoover, D. M., Yang, D., Boulègue, C., Santamaria, F., Oppenheim, J. J., Lubkowski, J. T., & Lu, W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1533186100 · Cited by 439 · see citing works

Crystallization of Antimicrobial Pores in Membranes: Magainin and Protegrin

Yang, L., Weiss, T. M., Lehrer, R. I., & Huang, H. W. (2000) · Biophysical Journal · doi:10.1016/s0006-3495(00)76448-4 · Cited by 439 · see citing works

Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A

Conejo-Garcia, J. R., Benencia, F., Courreges, M. C., Kang, E. H., Mohamed-Hadley, A. A., Buckanovich, R. J., Holtz, D. O., Jenkins, A., Na, H., Zhang, L., et al. (2004) · Nature Medicine · doi:10.1038/nm1097 · Cited by 438 · see citing works

Chemokines in Immunity

Yoshie, O., Imai, T., & Nomiyama, H. (2001) · Advances in immunology · doi:10.1016/s0065-2776(01)78002-9 · Cited by 428 · see citing works

Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, β-defensins and LL37, produced by human epithelial cells

Ouhara, K., Komatsuzawa, H., Yamada, S., Shiba, H., Fujiwara, T., Ohara, M., Sayama, K., Hashimoto, K., Kurihara, H., & Sugai, M. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki103 · Cited by 427 · see citing works

IL-17 Markedly Up-Regulates β-Defensin-2 Expression in Human Airway Epithelium via JAK and NF-κB Signaling Pathways

Kao, C.-Y., Chen, Y., Thai, P., Wachi, S., Huang, F., Kim, C., Harper, R. W., & Wu, R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.3482 · Cited by 424 · see citing works

Inducible Expression of Human β-Defensin 2 byFusobacterium nucleatumin Oral Epithelial Cells: Multiple Signaling Pathways and Role of Commensal Bacteria in Innate Immunity and the Epithelial Barrier

Krisanaprakornkit, S., Kimball, J. R., Weinberg, A., Darveau, R. P., Bainbridge, B. W., & Dale, B. A. (2000) · Infection and Immunity · doi:10.1128/iai.68.5.2907-2915.2000 · Cited by 419 · see citing works

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

Jaynes, J. M., Sable, R. V., Ronzetti, M. H., Bautista, W., Knotts, Z., Abisoye-Ogunniyan, A., Li, D., Calvo, R., Dashnyam, M., Singh, A., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax6337 · Cited by 412 · see citing works

Chemokines and Their Receptors in the Central Nervous System

Bajetto, A., Bonavia, R., Barbero, S., Florio, T., & Schettini, G. (2001) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2001.0214 · Cited by 416 · see citing works

Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa

Salzman, N. H., Underwood, M. A., & Bevins, C. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.04.002 · Cited by 414 · see citing works

Identification of a novel, multifunctional *-defensin (human *-defensin 3) with specific antimicrobial activity

Conejo-Garcia, J. R., Jaumann, F., Schulz, S., Krause, A., Rodríguez-Jiménez, J., Forssmann, U., Adermann, K., Klüver, E., Vogelmeier, C. F., Becker, D., et al. (2001) · Cell and Tissue Research · doi:10.1007/s004410100433 · Cited by 408 · see citing works

Alarmins and immunity

Yang, D., Han, Z., & Oppenheim, J. J. (2017) · Immunological Reviews · doi:10.1111/imr.12577 · Cited by 412 · see citing works

Development of a Novel Proteomic Approach for the Detection of Transitional Cell Carcinoma of the Bladder in Urine

Vlahou, A., Schellhammer, P. F., Mendrinos, S. E., Patel, K., Kondylis, F. I., Gong, L., Nasim, S., & Wright, G. L. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64100-4 · Cited by 409 · see citing works

Roles of antimicrobial peptides such as defensins in innate and adaptive immunity

Oppenheim, J. J., Biragyn, A., Kwak, L. W., & Yang, D. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.suppl_2.ii17 · Cited by 407 · see citing works

Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia

McAuley, J. L., Hornung, F., Boyd, K. L., Smith, A. M., McKeon, R., Bennink, J., Yewdell, J. W., & McCullers, J. A. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.09.001 · Cited by 389 · see citing works

An overview of IL-17 function and signaling

Gaffen, S. L. (2008) · Cytokine · doi:10.1016/j.cyto.2008.07.017 · Cited by 376 · see citing works

Cutting Edge: IFN-Inducible ELR− CXC Chemokines Display Defensin-Like Antimicrobial Activity

Cole, A. M., Ganz, T., Liese, A. M., Burdick, M. D., Liu, L., & Strieter, R. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.2.623 · Cited by 382 · see citing works

Antimicrobial peptides

Izadpanah, A., & Gallo, R. L. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.08.026 · Cited by 381 · see citing works

Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes

Lawrance, I. C. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.445 · Cited by 380 · see citing works

Macrophage Inflammatory Protein 3α Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors

Dieu‐Nosjean, M., Massacrier, C., Homey, B., Vanbervliet, B., Pin, J., Vicari, A. P., Lebecque, S., Dezutter‐Dambuyant, C., Schmitt, D., Zlotnik, A., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.5.705 · Cited by 378 · see citing works

Human β-defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2

Funderburg, N., Lederman, M. M., Feng, Z., Drage, M. G., Jadlowsky, J. K., Harding, C. V., Weinberg, A., & Sieg, S. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702130104 · Cited by 377 · see citing works

Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes

Nagy, I., Pivarcsi, A., Kis, K., Koreck, A., Bodai, L., McDowell, A., Seltmann, H., Patrick, S., Zouboulis, C. C., & Kemény, L. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.04.001 · Cited by 375 · see citing works

Bacterial strategies of resistance to antimicrobial peptides

Joo, H., Fu, C.-I., & Otto, M. J. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0292 · Cited by 362 · see citing works

Interleukin-17 and its expanding biological functions

Xu, S., & Cao, X. (2010) · Cellular and Molecular Immunology · doi:10.1038/cmi.2010.21 · Cited by 358 · see citing works

Induction of Keratinocyte Migration via Transactivation of the Epidermal Growth Factor Receptor by the Antimicrobial Peptide LL-37

Tokumaru, S., Sayama, K., Shirakata, Y., Komatsuzawa, H., Ouhara, K., Hanakawa, Y., Yahata, Y., Dai, X., Tohyama, M., Nagai, H., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4662 · Cited by 357 · see citing works

β-Defensin-2 Expression Is Regulated by TLR Signaling in Intestinal Epithelial Cells

Vora, P., Youdim, A., Thomas, L. S., Fukata, M., Tesfay, S., Lukasek, K., Michelsen, K. S., Wada, A., Hirayama, T., Arditi, M., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5398 · Cited by 358 · see citing works

The human beta-defensin-3, an antibacterial peptide with multiple biological functions

Dhople, V. M., Krukemeyer, A. M., & Ramamoorthy, A. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.07.007 · Cited by 358 · see citing works

Extensive Normal Copy Number Variation of a β-Defensin Antimicrobial-Gene Cluster

Hollox, E. J., Armour, J. A. L., & Barber, J. C. K. (2003) · The American Journal of Human Genetics · doi:10.1086/378157 · Cited by 354 · see citing works

A β-Defensin Mutation Causes Black Coat Color in Domestic Dogs

Candille, S. I., Kaelin, C. B., Cattanach, B. M., Yu, B., Thompson, D. A., Nix, M. A., Kerns, J. A., Schmutz, S. M., Millhauser, G. L., & Barsh, G. S. (2007) · Science · doi:10.1126/science.1147880 · Cited by 351 · see citing works

Human β-Defensin 2 and 3 and Their Mouse Orthologs Induce Chemotaxis through Interaction with CCR2

Röhrl, J., Yang, D., Oppenheim, J. J., & Hehlgans, T. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903984 · Cited by 296 · see citing works

Specific Binding and Chemotactic Activity of mBD4 and Its Functional Orthologue hBD2 to CCR6-expressing Cells

Röhrl, J., Yang, D., Oppenheim, J. J., & Hehlgans, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.091090 · Cited by 89 · see citing works

Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

Yang, D., Chen, Q., Chertov, O., & Oppenheim, J. J. (2000) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.1.9 · Cited by 501 · see citing works

Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37)

Yang, D., Chertov, O., & Oppenheim, J. J. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.5.691 · Cited by 276 · see citing works

Defensin‐related peptide 1 (Defr1) is allelic to Defb8 and chemoattracts immature DC and CD4+ T cells independently of CCR6

Taylor, K. J., Rolfe, M., Reynolds, N. L., Kilanowski, F. M., Pathania, U., Clarke, D. J., Yang, D., Oppenheim, J. J., Samuel, K., Howie, S., et al. (2009) · European Journal of Immunology · doi:10.1002/eji.200838566 · Cited by 22 · see citing works