Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP12

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Items 301–400 of 435

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4. NKG2H-Expressing T Cells Negatively Regulate Immune Responses
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5. Amyloids in Site-Specific Autoimmune Reactions and Inflammatory Responses
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6. Evaluation of the relationship between TREM‐1/TREM‐2 ratio and clinical course in COVID‐19 pneumonia
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7. Control of Pathogenic CD4 T Cells and Lethal Immunopathology by Signaling Immunoadaptor DAP12 during Influenza Infection
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9. The emerging role of the microglia triggering receptor expressed on myeloid cells (TREM) 2 in multiple sclerosis
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10. Negative regulation of inflammatory responses by immunoglobulin A receptor (FcαRI) inhibits the development of Toll-like receptor-9 signalling-accelerated glomerulonephritis
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11. Mediators of Tyrosine Phosphorylation in Innate Immunity: From Host Defense to Inflammation onto Oncogenesis
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12. Triggering Receptor Expressed on Myeloid Cells 2 Mediates the Involvement of M2-Type Macrophages in Pulmonary Tuberculosis Infection
    Xiaoqian Shang, Naifeisha Maimaiti, Jiahui Fan, Liang Wang, Yuanyuan Wang, Hu Sun, Jie Lv, Xiufeng Zhang, Jing Wang, Xiumin Ma · 2024 · Journal of Inflammation Research
13. Serum sTREM2: A Potential Biomarker for Mild Cognitive Impairment in Patients With Obstructive Sleep Apnea
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14. TREM-2: friend or foe in infectious diseases?
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15. Integrative toxicogenomics-based approach to risk assessment of heavy metal mixtures/complexes: strategies and challenges
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16. Construction, Expression, and Purification of Chimeric Protein Reagents Based on Immunoglobulin Fc Regions
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17. TREM-2 negatively regulates LPS-mediated inflammatory response in rat bone marrow-derived MSCs
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18. Environmental factors determine DAP 12 deficiency to either enhance or suppress immunopathogenic processes
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19. Both TREM2-dependent macrophages and Kupffer cells play a protective role in APAP-induced acute liver injury
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20. TREM2 in Regulating Macrophage Inflammatory Responses and Disease Pathogenesis
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21. sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK–JNK Signaling Pathway
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22. Temporal-logic analysis of microglial phenotypic conversion with exposure to amyloid-β
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23. Close Encounters of the First Kind: Innate Sensors and Multiple Sclerosis
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24. Contribution of Interleukin‐6/gp130 Signaling in Hepatocytes to the Inflammatory Response in Mice Infected with Streptococcus pyogenes
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25. RhoA/ROCK/GSK3β Signaling: A Keystone in Understanding Alzheimer’s Disease
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26. Lipid-Metabolically Active TREM2high Microglia‑Derived Macrophages Predict Poor Prognosis and Represent an Immunotherapeutic Target in Glioma
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27. Mechanistic Role of Jak3 in Obesity-Associated Cognitive Impairments
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28. Blockade of CD354 (TREM-1) Ameliorates Anti-GBM-Induced Nephritis
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29. Triggering receptor expressed on myeloid cells‐2 stimulates osteoclast differentiation and bone loss in periodontitis
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30. Genomic Modifiers of Natural Killer Cells, Immune Responsiveness and Lymphoid Tissue Remodeling Together Increase Host Resistance to Viral Infection
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31. Increased diabetes development and decreased function of CD4+CD25+ Treg in the absence of a functional DAP12 adaptor protein
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32. TREM2 promotes natural killer cell development in CD3−CD122+NK1.1+ pNK cells
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33. Unraveling the Molecular Dance: Insights into TREM2/DAP12 Complex Formation in Alzheimer’s Disease through Molecular Dynamics Simulations
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34. Role of TREM2 in neuroinflammation regulation: mechanisms, disease associations, and therapeutic translation advances
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35. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) positively regulates lipopolysaccharide-induced expression of CXC chemokine ligand 10 and 11 in mouse macrophages
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36. Emerging non-proinflammatory roles of microglia in healthy and diseased brains
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37. The role of triggering receptor expressed on myeloid cells 2 in Parkinson’s disease and other neurodegenerative disorders
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38. Synthetic cleavage-resistant TREM2 boosts macrophage efferocytosis to treat inflammatory diseases
    Xianghui Dong, Xiaotian Zhao, Jinxin Gao, Longyu Bo, Yan Li, Zhichao Kong, 孙维绎, Xinxin Xu, Zhanyan Liu, Qirui Xiu et al. · 2026 · Cell Reports Medicine
39. Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Exacerbates Methamphetamine-Induced Activation of Microglia and Neuroinflammation
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40. FcγRIIb Exacerbates LPS-Induced Neuroinflammation by Binding with the Bridging Protein DAP12 and Promoting the Activation of PI3K/AKT Signaling Pathway in Microglia
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41. Chemical and Pharmacological Prospection of the Ascidian Cystodytes dellechiajei
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42. Stimuli and Relevant Signaling Cascades for NFATc1 in Bone Cell Homeostasis: Friend or Foe?
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43. The Role of TREM2 After Stroke: From Mechanisms to Therapeutic Potential
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44. TREM2 as an independent predictor of poor prognosis promotes the migration via the PI3K/AKT axis in prostate cancer.
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45. Computational analysis of Alzheimer's disease-associated missense SNPs to understand underlying molecular mechanisms and identify diagnostic biomarkers
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46. TREM2 as a Therapeutic Target in Atherosclerosis
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47. Pertussis toxin targets the innate immunity through DAP12, FcRγ, and MyD88 adaptor proteins
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48. DNA Methylation in Neuronal Development and Disease
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49. Substrate Selection Criteria in Regulated Intramembrane Proteolysis
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50. TREM2 coding variants in Slovak Alzheimer's disease patients
    Vladimı́ra Ďurmanová, Juraj Javor, Zuzana Párnická, Gabriel Minárik, Agata Ocenasova, Barbora Vašečková, Iliana Kiralyova, Stanislav Šutovský, Róbert Petrovič, Ivana Shawkatová · 2022 · Journal of Integrative Neuroscience
51. Druggable targets for the immunopathy of Alzheimer's disease
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52. Diagnostic value of TREM-1 and TREM-2 expression in bronchoalveolar lavage fluid in sarcoidosis and other lung diseases
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53. γ-Secretase fanning the fire of innate immunity
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54. Soluble epoxide hydrolase inhibition impairs triggering receptor expressed on myeloid cells‐1 in periodontal tissue
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55. Association of preoperative cerebrospinal fluid sTREM2 concentration with postoperative delirium and 3-year mortality in patients total knee or hip arthroplasty: a prospective cohort study
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56. Adaptive individualized gene pair signatures distinguishing melanoma and predicting response to immune checkpoint blockade
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57. Identification and potential mechanism of different components from the aerial part of Bupleurum chinense DC. for epileptic treatment
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58. Sex-specific transcriptional regulation in lung macrophages during sub-acute Mycobacterium tuberculosis infection
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59. TREM2 as a possible link between Alzheimer's disease and diabetes mellitus
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60. The role of DAP12 in immune-related inflammatory diseases
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61. DNAX-Activating Protein of 12 kDa Impairs Host Defense in Pneumococcal Pneumonia
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62. Insights into lipid-modified recognition of Apolipoprotein E3 to extra-cellular domain of TREM2 associated with Alzheimer’s disease
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63. Toxoplasma gondii-induced adverse pregnancy outcomes: insight into the inhibitory role of Trem2 on TLR4/TRAF6/JNK signaling pathway
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64. Mechanistic Disruption of the TREM2–DAP12 Transmembrane Complex by Alzheimer’s Disease Mutations: A Multiscale Simulation Study
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65. Toxicogenomic Approach to Risk Assessment of Welding Fumes
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66. Clusterin from endometrial glands plays a critical role in decidualization via Trem2
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67. NK Cells: Null No More
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68. TRAPC : A novel Triggering Receptor expressed on Antigen Presenting Cells
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75. TREM2-mediated recognition of candidalysin by macrophages confers early protective innate immunity in oropharyngeal candidiasis
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