Characterization and functional consequences of underexpression of clusterin in rheumatoid arthritis

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

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Revised Criteria for the Classification of Rheumatoid Arthritis

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Rheumatoid Arthritis

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Discovery and analysis of inflammatory disease-related genes using cDNA microarrays

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Clusterin

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NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint

Miagkov, A., Kovalenko, D. V., Brown, C. E., Didsbury, J. R., Cogswell, J. P., Stimpson, S. A., Baldwin, A. S., & Makarov, S. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13859 · Cited by 466 · see citing works

NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction.

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Synthesis and Functional Analyses of Nuclear Clusterin, a Cell Death Protein

Leskov, K., Klokov, D. Y., Li, J., Kinsella, T. J., & Boothman, D. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209233200 · Cited by 395 · see citing works

Clusterin/Apolipoprotein J in human aging and cancer

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Angiopoietin-Like 4 Is a Proangiogenic Factor Produced during Ischemia and in Conventional Renal Cell Carcinoma

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SP-40,40, a newly identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis.

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Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death

Yang, C., Leskov, K., Hosley, K., Criswell, T. L., Pink, J. J., Kinsella, T. J., & Boothman, D. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.5907 · Cited by 277 · see citing works

Silencing Expression of the Clusterin/Apolipoprotein J Gene in Human Cancer Cells Using Small Interfering RNA Induces Spontaneous Apoptosis, Reduced Growth Ability, and Cell Sensitization to Genotoxic and Oxidative Stress

Trougakos, I. P., So, A., Jansen, B., Gleave, M. E., & Gonos, E. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2664 · Cited by 207 · see citing works

Defining therapeutic targets by using adenovirus: Blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators

Bondeson, J., Foxwell, B. M. J., Brennan, F. M., & Feldmann, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5668 · Cited by 207 · see citing works

Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis

McLaughlin, L., Zhu, G., Mistry, M. J., Ebert, C., Stuart, W. D., Florio, C. J., Groen, P. A., Witt, S. A., Kimball, T. R., Witte, D. P., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9037 · Cited by 206 · see citing works

Apolipoprotein J expression at fluid-tissue interfaces: potential role in barrier cytoprotection.

Aronow, B. J., Lund, S., Brown, T. L., Harmony, J. A. K., & Witte, D. P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.725 · Cited by 198 · see citing works

Clusterin is an extracellular chaperone that specifically interacts with slowly aggregating proteins on their off‐folding pathway

Poon, S., Treweek, T. M., Wilson, M. R., Easterbrook‐Smith, S. B., & Carver, J. A. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02326-8 · Cited by 139 · see citing works

Essential Requirement of Apolipoprotein J (Clusterin) Signaling for IκB Expression and Regulation of NF-κB Activity

Santilli, G., Aronow, B. J., & Sala, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300252200 · Cited by 138 · see citing works

Nucleotide-based therapies targeting clusterin chemosensitize human lung adenocarcinoma cells bothin vitroandin vivo

July, L. V., Beraldi, E., So, A., Fazli, L., Evans, K. G., English, J. C., & Gleave, M. E. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.223.3.3 · Cited by 132 · see citing works

NF-κB Regulation by IκB Kinase-2 in Rheumatoid Arthritis Synoviocytes

Aupperle, K. R., Bennett, B. L., Han, Z., Boyle, D. L., Manning, A. M., & Firestein, G. S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.4.2705 · Cited by 130 · see citing works

Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis

French, L. E., Chonn, A., Ducrest, D., Baumann, B., Belin, D., Wohlwend, A., Kiss, J., Sappino, A.-P., Tschopp, J., & Schifferli, J. A. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.5.1119 · Cited by 125 · see citing works

Glycobiology and Cancer: Meeting Summary and Future Directions

Hart, G. W., Lowe, J. B., & Sathyamoorthy, N. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.2.775 · Cited by 120 · see citing works

Clusterin Biogenesis Is Altered during Apoptosis in the Regressing Rat Ventral Prostate

Lakins, J. N., Bennett, S. A. L., Chen, J.-H., Arnold, J. M., Morrissey, C. M., WONG, P. W. K., O'Sullivan, J. N., & Tenniswood, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.27887 · Cited by 107 · see citing works

Intracellular Clusterin Induces G2-M Phase Arrest and Cell Death in PC-3 Prostate Cancer Cells1

Scaltriti, M., Santamaría, A., Paciucci, R., & Bettuzzi, S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0920 · Cited by 104 · see citing works

Presence of pannus-like tissue on osteoarthritic cartilage and its histological character

Shibakawa, A., Aoki, H., Masuko, K., Kato, T., Tanaka, M., Nishioka, K., & Nakamura, H. (2003) · Osteoarthritis and Cartilage · doi:10.1053/joca.2002.0871 · Cited by 92 · see citing works

DNA microarray allows molecular profiling of rheumatoid arthritis and identification of pathophysiological targets

Devauchelle‐Pensec, V., Marion, S., Cagnard, N., Mistou, S., Falgarone, G., Bréban, M., Letourneur, F., Pitaval, A., Alibert, O., Lucchesi, C., et al. (2004) · Genes and Immunity · doi:10.1038/sj.gene.6364132 · Cited by 92 · see citing works

Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression

Bettuzzi, S., Scorcioni, F., Astancolle, S., Davalli, P., Scaltriti, M., & Corti, A. (2002) · Oncogene · doi:10.1038/sj.onc.1205594 · Cited by 85 · see citing works

Terminal complement pathway activation and low lysis inhibitors in rheumatoid arthritis synovial fluid.

Högåsen, K., Mollnes, T. E., Harboe, M., Götze, O., Hammer, H. B., & Oppermann, M. (1995) · PubMed · Cited by 82 · see citing works

Differential effects of clusterin/apolipoprotein J on cellular growth and survival

Trougakos, I. P., Lourda, M., Agiostratidou, G., Kletsas, D., & Gonos, E. S. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.038 · Cited by 78 · see citing works

Intracellular clusterin causes juxtanuclear aggregate formation and mitochondrial alteration

Debure, L., Vayssière, J., Rincheval, V., Loison, F., Dréan, Y. L., & Michel, D. (2003) · Journal of Cell Science · doi:10.1242/jcs.00619 · Cited by 77 · see citing works

Clusterin/apolipoprotein J is a novel biomarker of cellular senescence that does not affect the proliferative capacity of human diploid fibroblasts

Petropoulou, C., Trougakos, I. P., Kolettas, E., Toussaint, O., & Gonos, E. S. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03150-7 · Cited by 74 · see citing works

Heterogeneous requirement of IκB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: Implications for therapy

Andreakos, E., Smith, C., Kiriakidis, S., Monaco, C. G., de Martin, R., Brennan, F. M., Paleolog, E. M., Feldmann, M., & Foxwell, B. M. J. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11044 · Cited by 65 · see citing works

Clusterin, an Abundant Serum Factor, Is a Possible Negative Regulator of MT6-MMP/MMP-25 Produced by Neutrophils

Matsuda, A., Itoh, Y., Koshikawa, N., Akizawa, T., Yana, I., & Seiki, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301509200 · Cited by 62 · see citing works

Clusterin expression in adult human normal and osteoarthritic articular cartilage

Connor, J. R., Kumar, S., Sathe, G. M., Mooney, J., O'Brien, S. P., Mui, P., Murdock, P. R., Gowen, M., & Lark, M. W. (2001) · Osteoarthritis and Cartilage · doi:10.1053/joca.2001.0475 · Cited by 59 · see citing works

Systemic lupus erythematosus, a disease associated with low levels of clusterin/apoJ, an antiinflammatory protein.

Newkirk, M. M., Apostolakos, P., Neville, C., & Fortin, P. R. (1999) · PubMed · Cited by 49 · see citing works

Expression and Regulation of Inducible IκB Kinase (IKK-i) in Human Fibroblast-like Synoviocytes

Aupperle, K. R., Yamanishi, Y., Bennett, B. L., Mercurio, F., Boyle, D. L., & Firestein, G. S. (2001) · Cellular Immunology · doi:10.1006/cimm.2002.1885 · Cited by 37 · see citing works

Chromosomal assignment of the human homologue encoding SGP-2

Slawin, K., Sawczuk, I. S., Olsson, C. A., & Buttyan, R. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80187-1 · Cited by 26 · see citing works

Comparable histological appearance of synovitis in seropositive and seronegative rheumatoid arthritis.

Fujinami, M., Sato, K., Kashiwazaki, S., & Aotsuka, S.-I. (1997) · PubMed · Cited by 18 · see citing works

Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling

Miao, C., Yang, Y., He, X., Li, X., Huang, C. Z., Huang, Y., Zhang, L., Lv, X., Jin, Y. J., & Li, J. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.04.002 · Cited by 201 · see citing works

Tumor Necrosis Factor α Induces Sustained Signaling and a Prolonged and Unremitting Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts

Lee, A., Qiao, Y., Grigoriev, G., Chen, J., Park‐Min, K., Park, S. H., Ivashkiv, L. B., & Kalliolias, G. D. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37853 · Cited by 155 · see citing works

Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex

Trougakos, I. P., Lourda, M., Antonelou, M. H., Kletsas, D., Gorgoulis, V. G., Papassideri, I. S., Zou, Y., Margaritis, L. H., Boothman, D. A., & Gonos, E. S. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1805 · Cited by 160 · see citing works

Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses

Cunin, P., Beauvillain, C., Miot, C., Augusto, J., Preisser, L., Blanchard, S., Pignon, P., Scotet, M., Garo, E., Frémaux, I., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.113 · Cited by 132 · see citing works

Clusterin Facilitates COMMD1 and I-κB Degradation to Enhance NF-κB Activity in Prostate Cancer Cells

Zoubeidi, A., Ettinger, S., Beraldi, E., Hadaschik, B. A., Zardan, A., Klomp, L. W. J., Nelson, C. C., Rennie, P. S., & Gleave, M. E. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0277 · Cited by 130 · see citing works

The clusterin paradigm in prostate and breast carcinogenesis

Rizzi, F., & Bettuzzi, S. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0140 · Cited by 105 · see citing works

Chapter 8 Clusterin

Falgarone, G., & Chiocchia, G. (2009) · Advances in cancer research · doi:10.1016/s0065-230x(09)04008-1 · Cited by 105 · see citing works

Interaction of Clusterin and Matrix Metalloproteinase-9 and Its Implication for Epithelial Homeostasis and Inflammation

Jeong, S., Ledee, D. R., Gordon, G. M., Itakura, T., Patel, N. N., Martin, A. J., & Fini, M. E. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.01.025 · Cited by 101 · see citing works

Clusterin induces matrix metalloproteinase-9 expression via ERK1/2 and PI3K/Akt/NF-κB pathways in monocytes/macrophages

Shim, Y.-J., Kang, B.-H., Jeon, H.-S., Park, I.-S., Lee, K., Lee, I. K., Park, G. H., Lee, K., Schedin, P. S., & Min, B.-H. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0311110 · Cited by 93 · see citing works

Clusterin, a Haploinsufficient Tumor Suppressor Gene in Neuroblastomas

Chayka, O., Corvetta, D., Dews, M., Caccamo, A. E., Piotrowska, I., Santilli, G., Gibson, S., Sebire, N. J., Himoudi, N., Hogarty, M. D., et al. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp063 · Cited by 85 · see citing works

A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin

Deming, Y., Xia, J., Cai, Y., Lord, J., Holmans, P., Bertelsen, S., Holtzman, D., Morris, J. C., Bales, K., Pickering, E. H., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.09.009 · Cited by 66 · see citing works

Clusterin in Alzheimer's disease

Wu, Z., Yu, J., Li, Y., & Tan, L. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-394317-0.00011-x · Cited by 62 · see citing works

Mass spectrometry assays of plasma biomarkers to predict radiographic progression of knee osteoarthritis

Ritter, S. Y., Collins, J. E., Krastins, B., Sarracino, D. A., Lopez, M. F., Losina, E., & Aliprantis, A. O. (2014) · Arthritis Research & Therapy · doi:10.1186/s13075-014-0456-6 · Cited by 62 · see citing works

Chapter 9 Oxidative Stress in Malignant Progression

Trougakos, I. P., & Gonos, E. S. (2009) · Advances in cancer research · doi:10.1016/s0065-230x(09)04009-3 · Cited by 59 · see citing works

Fractalkine mediates T cell–dependent proliferation of synovial fibroblasts in rheumatoid arthritis

Sawai, H., Park, Y. W., He, X., Goronzy, J. J., & Weyand, C. M. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22919 · Cited by 58 · see citing works

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density

Lish, A. M., Grogan, E. F. L., Benoit, C. R., Pearse, R. V., Heuer, S. E., Luquez, T., Orme, G. A., Galle, P. C., Milinkeviciute, G., Green, K. N., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.03.034 · Cited by 53 · see citing works

The tumour-suppressive function of CLU is explained by its localisation and interaction with HSP60

Chaiwatanasirikul, K.-A., & Sala, A. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.99 · Cited by 51 · see citing works

Regulation of CLU Gene Expression by Oncogenes and Epigenetic Factors

Sala, A., Bettuzzi, S., Pucci, S., Chayka, O., Dews, M., & Thomas‐Tikhonenko, A. (2009) · Advances in cancer research · doi:10.1016/s0065-230x(09)05007-6 · Cited by 50 · see citing works

Putative circulating markers of the early and advanced stages of breast cancer identified by high-resolution label-free proteomics

Panis, C., Pizzatti, L., Herrera, A. C. D. S. D. A., Cecchini, R., & Abdelhay, E. S. F. W. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.020 · Cited by 51 · see citing works

Clusterin as modulator of carcinogenesis: A potential avenue for targeted cancer therapy

Praharaj, P. P., Patra, S., Panigrahi, D. P., Patra, S. K., & Bhutia, S. K. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188500 · Cited by 49 · see citing works

Assessment of Lipocalin 2, Clusterin, Soluble Tumor Necrosis Factor Receptor-1, Interleukin-6, Homocysteine, and Uric Acid Levels in Patients with Psoriasis

Ataseven, A., Keşli, R., Kurtipek, G. S., & Öztürk, P. (2014) · Disease Markers · doi:10.1155/2014/541709 · Cited by 49 · see citing works

Identification of Clusterin Domain Involved in NF-κB Pathway Regulation

Essabbani, A., Margottin-Goguet, F., & Chiocchia, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.c109.057133 · Cited by 42 · see citing works

The Roles of B Cells and Their Interactions with Fibroblast-Like Synoviocytes in the Pathogenesis of Rheumatoid Arthritis

Wang, Q., Ma, Y., Liu, D., Zhang, L., & Wei, W. (2011) · International Archives of Allergy and Immunology · doi:10.1159/000321185 · Cited by 40 · see citing works

Seminal Clusterin Gene Expression Associated with Seminal Variables in Fertile and Infertile Men

Zalata, A. A. E.-K., Elsamanoudy, A. Z., Shaalan, D., El-Baiomy, Y., Taymour, M., & Mostafa, T. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.06.012 · Cited by 39 · see citing works

Vanadium‐induced apoptosis of HaCaT cells is mediated by c‐fos and involves nuclear accumulation of clusterin

Markopoulou, S., Kontargiris, E., Batsi, C., Tzavaras, T., Trougakos, I. P., Boothman, D. A., Gonos, E. S., & Kolettas, E. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07093.x · Cited by 37 · see citing works

Clusterin in the eye: An old dog with new tricks at the ocular surface

Fini, M. E., Bauskar, A., Jeong, S., & Wilson, M. R. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.04.019 · Cited by 36 · see citing works

Diverse functions of clusterin promote and protect against the development of pulmonary fibrosis

Peix, L., Evans, I., Pearce, D. R., Simpson, J. K., Maher, T. M., & McAnulty, R. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-20316-1 · Cited by 32 · see citing works

Clusterin, other extracellular chaperones, and eye disease

Wilson, M. R., Satapathy, S., Jeong, S., & Fini, M. E. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.101032 · Cited by 34 · see citing works

Increased expression levels of apolipoprotein J/clusterin during primary osteoarthritis.

Fandridis, E. M., Apergis, G. A., Korres, D. S., Nikolopoulos, K., Zoubos, A. B., Papassideri, I. S., & Trougakos, I. P. (2011) · PubMed · Cited by 34 · see citing works

Analysis of the Hippocampal Proteome in ME7 Prion Disease Reveals a Predominant Astrocytic Signature and Highlights the Brain-restricted Production of Clusterin in Chronic Neurodegeneration

Asuni, A. A., Gray, B., Bailey, J., Skipp, P., Perry, V. H., & O'Connor, V. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.502690 · Cited by 31 · see citing works

From transcriptome to cytome: Integrating cytometric profiling, multivariate cluster, and prediction analyses for a phenotypical classification of inflammatory diseases

Steinbrich‐Zöllner, M., Grün, J. R., Kaiser, T., Biesen, R., Raba, K., Wu, P., Thiel, A., Rudwaleit, M., Sieper, J., Burmester, G. R., et al. (2008) · Cytometry Part A · doi:10.1002/cyto.a.20505 · Cited by 29 · see citing works

Regulation of adipocyte differentiation by clusterin‐mediated Krüppel‐like factor 5 stabilization

Oh, G., Yoon, J. H., Kim, G., Kim, G. H., Kim, D. S., Choi, B., Chang, E., Lee, E., & Kim, S. (2020) · The FASEB Journal · doi:10.1096/fj.202000551rr · Cited by 26 · see citing works

Chapter 7 Cell Protective Functions of Secretory Clusterin (sCLU)

Klock, G., Baiersdörfer, M., & Koch-Brandt, C. (2009) · Advances in cancer research · doi:10.1016/s0065-230x(09)04007-x · Cited by 26 · see citing works

Localization of the Potential Zonal Marker Clusterin in Native Cartilage and in Tissue-Engineered Constructs

Malda, J., ten Hoope, W., Schuurman, W., van Osch, G. J. V. M., van Weeren, P. R., & Dhert, W. J. A. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0376 · Cited by 26 · see citing works

Clusterin Is Associated with Systemic and Synovial Inflammation in Knee Osteoarthritis

Ungsudechachai, T., Honsawek, S., Jittikoon, J., & Udomsinprasert, W. (2020) · Cartilage · doi:10.1177/1947603520958149 · Cited by 25 · see citing works

The Ins and Outs of Clusterin: Its Role in Cancer, Eye Diseases and Wound Healing

Gross, C., Guérin, L.-P., Socol, B. G., Germain, L., & Guérin, S. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713182 · Cited by 25 · see citing works

Exploring the translational potential of clusterin as a biomarker of early osteoarthritis

Kalvaityte, U., Matta, C., Bernotienė, E., Pushparaj, P. N., Kiapour, A. M., & Mobasheri, A. (2021) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2021.10.001 · Cited by 24 · see citing works

Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis Vulgaris

Holmannová, D., Borský, P., Borská, L., Andrýs, C., Hamáková, K., Řeháček, V., Švadláková, T., Málková, A., Beránek, M., Palička, V., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165617 · Cited by 23 · see citing works

Alteration in the activation state of new inflammation-associated targets by phospholipase A2-activating protein (PLAA)

Zhang, F., Sha, J., Wood, T. G., Galindo, C. L., Garner, H. R., Burkart, M. F., Suárez, G., Sierra, J. C., Agar, S. L., Peterson, J. W., et al. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.01.004 · Cited by 22 · see citing works

Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain

Kropáčková, T., Šléglová, O., Růžičková, O., Vencovský, J., Pavelká, K., & Šenolt, L. (2018) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-018-2179-3 · Cited by 20 · see citing works

Clusterin secretion is attenuated by the proinflammatory cytokines interleukin‐1β and tumor necrosis factor‐α in models of cartilage degradation

Matta, C., Fellows, C. R., Quasnichka, H. L., Williams, A., Jeremiasse, B., Allaway, D., & Mobasheri, A. (2020) · Journal of Orthopaedic Research® · doi:10.1002/jor.24814 · Cited by 18 · see citing works

Clusterin exacerbates interleukin-1β-induced inflammation via suppressing PI3K/Akt pathway in human fibroblast-like synoviocytes of knee osteoarthritis

Ungsudechachai, T., Honsawek, S., Jittikoon, J., & Udomsinprasert, W. (2022) · Scientific Reports · doi:10.1038/s41598-022-14295-7 · Cited by 17 · see citing works

Secretory clusterin inhibits osteoclastogenesis by attenuating M-CSF-dependent osteoclast precursor cell proliferation

Choi, B., Kang, S.-S., Kang, S.-W., Min, B.-H., Lee, E. J., Song, D.-H., Kim, S., Song, Y., Yoon, S.-Y., & Chang, E.-J. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.05.074 · Cited by 17 · see citing works

Comparative analysis of serum proteomes of degenerative scoliosis

Zhu, Y., Han, S., Zhao, H., Liang, J., Zhai, J., Wu, Z., & Qiu, G. (2011) · Journal of Orthopaedic Research® · doi:10.1002/jor.21466 · Cited by 16 · see citing works

Clusterin serum levels are elevated in patients with early rheumatoid arthritis and predict disease activity and treatment response

Kropáčková, T., Mann, H. F., Růžičková, O., Šléglová, O., Vernerová, L., Horváthová, V., Tomčík, M., Pavelká, K., Vencovský, J., & Šenolt, L. (2021) · Scientific Reports · doi:10.1038/s41598-021-90973-2 · Cited by 15 · see citing works

The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis

Kovács, P., Pushparaj, P. N., Takács, R., Mobasheri, A., & Matta, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1103097 · Cited by 15 · see citing works

Inflammatory lipids as a target for therapy in the rheumatic diseases

McMahon, M. A., & Brahn, E. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.8.1213 · Cited by 15 · see citing works

Clusterin synergizes with IL-2 for the expansion and IFN-γ production of natural killer cells

Sonn, C. H., Yu, Y.-B., Hong, Y.-J., Shim, Y.-J., Bluestone, J. A., Min, B.-H., & Lee, K. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0310157 · Cited by 15 · see citing works

Potential plasma biomarkers for progression of knee osteoarthritis using glycoproteomic analysis coupled with a 2D-LC-MALDI system

Fukuda, I., Ishihara, T., Ohmachi, S., Sakikawa, I., Morita, A., Ikeda, M., Yamane, S., Toyosaki‐Maeda, T., Takinami, Y., Okamoto, H., et al. (2012) · Proteome Science · doi:10.1186/1477-5956-10-36 · Cited by 14 · see citing works

Podoplanin and Clusterin Are Reliable Markers of Nonneoplastic Synovium at Various Sites

Talmon, G. A., Wake, L. M., & Muirhead, D. E. (2013) · International Journal of Surgical Pathology · doi:10.1177/1066896913492195 · Cited by 13 · see citing works

Decreased Plasma Levels of Clusterin in Patients With Psoriasis

García‐Rodríguez, S., Arias‐Santiago, S., Perandrés-López, R., Orgaz‐Molina, J., Castellote, L., Buendía‐Eisman, A., Ruiz, J. C., Naranjo, R., Navarro, P., Sancho, J., et al. (2013) · Actas Dermo-Sifiliográficas · doi:10.1016/j.adengl.2012.11.018 · Cited by 13 · see citing works

Functional analysis of synovial fluid from osteoarthritic knee and carpometacarpal joints unravels different molecular profiles

Barreto, G., Soliymani, R., Baumann, M., Waris, E., Eklund, K. K., Zenobi‐Wong, M., & Lalowski, M. M. (2018) · Rheumatology · doi:10.1093/rheumatology/key232 · Cited by 12 · see citing works

Clusterin Silencing in Prostate Cancer Induces Matrix Metalloproteinases by an NF-κB-Dependent Mechanism

Bonacini, M., Negri, A., Davalli, P., Naponelli, V., Ramazzina, I., Lenzi, C., Bettuzzi, S., & Rizzi, F. (2019) · Journal of Oncology · doi:10.1155/2019/4081624 · Cited by 12 · see citing works

Survival in the rheumatoid synovium

Wachsmann, D., & Sibilia, J. (2011) · Joint Bone Spine · doi:10.1016/j.jbspin.2011.05.026 · Cited by 11 · see citing works

A possible contribution of elevated serum clusterin levels to the inhibition of digital ulcers and pulmonary arterial hypertension in systemic sclerosis

Yanaba, K., Asano, Y., Tada, Y., Sugaya, M., Kadono, T., & Sato, S. (2012) · Archives of Dermatological Research · doi:10.1007/s00403-012-1219-3 · Cited by 9 · see citing works

A Systemic Network Triggered by Human Cytomegalovirus Entry

Wang, A., Ren, L., & Li, H. (2011) · Advances in Virology · doi:10.1155/2011/262080 · Cited by 8 · see citing works

PoClu, a teleost Clusterin, acts as a negative regulator in complement activation and antibacterial immunity

Chen, G.-Y., Feng, J., Shi, W.-K., Wang, H.-Y., Zhang, J., & Li, X. (2023) · Aquaculture · doi:10.1016/j.aquaculture.2023.739791 · Cited by 8 · see citing works

Implication of clusterin in TNF-α response of rheumatoid synovitis: lesson from in vitro knock-down of clusterin in human synovial fibroblast cells

Falgarone, G., Essabbani, A., Dumont, F., Cagnard, N., Mistou, S., & Chiocchia, G. (2011) · Physiological Genomics · doi:10.1152/physiolgenomics.00095.2010 · Cited by 8 · see citing works

Disminución de los niveles plasmáticos de clusterina en pacientes con psoriasis

García‐Rodríguez, S., Arias‐Santiago, S., Perandrés-López, R., Orgaz‐Molina, J., Castellote, L., Buendía‐Eisman, A., Ruiz, J. C., Naranjo, R., Navarro, P., Sancho, J., et al. (2013) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2012.11.019 · Cited by 8 · see citing works

The importance of specific citrullinated clusterin and vimentin found in a multi-coloured bead-based citrulline-peptide array system in rheumatoid arthritis

Yoshizawa, Y., Nakao, T., Tsuritani, K., Yamada, T., Watanabe, N., Chiba, A., Robinson, W. H., & Miyake, S. (2020) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/ucnzun · Cited by 6 · see citing works

Serum Clusterin Level Could Reflect the Current Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Yoon, T., Ahn, S. S., Pyo, J. Y., Song, J. J., Park, Y., & Lee, S. (2021) · Yonsei Medical Journal · doi:10.3349/ymj.2021.62.11.1016 · Cited by 6 · see citing works

Proteomic Analysis of Sera from Common Variable Immunodeficiency Patients Undergoing Replacement Intravenous Immunoglobulin Therapy

Spadaro, G., D’Orio, C., Genovese, A., Galeotafiore, A., DˈAmbrosio, C., Giovanni, S. D., Vitale, M., Capasso, M., Lamberti, V., Scaloni, A., et al. (2011) · BioMed Research International · doi:10.1155/2011/706746 · Cited by 5 · see citing works

Preliminary Study on Clusterin Protein (sCLU) Expression in PC-12 Cells Overexpressing Wild-Type and Mutated (Swedish) AβPP genes Affected by Non-Steroid Isoprenoids and Water-Soluble Cholesterol

Pająk, B., Kania, E., Gołaszewska, A., & Orzechowski, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061481 · Cited by 5 · see citing works

Quantitative proteomic analysis of peripheral blood mononuclear cells in rheumatoid arthritis

Xinqiang, S., Liu, K., Ch, L., Lim, T., Lee, Y. M., & Yuan, L. (2018) · Rheumatology and Orthopedic Medicine · doi:10.15761/rom.1000140 · Cited by 4 · see citing works

Proteomic studies of an explant model of equine articular cartilage in response to pro-inflammatory and anti-inflammatory stimuli

Williams, A. (2014) · Nottingham ePrints (University of Nottingham) · Cited by 4 · see citing works

Get Spliced: Uniting Alternative Splicing and Arthritis

van Haaren, M. J. H., Steller, L. B., Vastert, S. J., Calis, J. J. A., & van Loosdregt, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158123 · Cited by 3 · see citing works

Comparative Serum Proteomic Analysis of Differentially Regulated Proteins in Patients with Rheumatoid Arthritis and Healthy Volunteers

Vasko, R., & Blaschke, S. (2016) · Journal of Arthritis · doi:10.4172/2167-7921.1000201 · Cited by 3 · see citing works

Apo J/clusterin expression and secretion: Evidence for 15-deoxy-Δ12,14-PGJ2-dependent mechanism

Gates, D., Dollin, K., Connolly, R. M., Young, I. S., Powell, L. A., McEneny, J., Gleave, M. E., & McGinty, A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.11.004 · Cited by 2 · see citing works

The Therapeutic and Prognostic Role of Clusterin in Diverse Musculoskeletal Diseases: A Mini Review

Zhang, K. M., Liu, K., Yu, D., Tang, Y., Geng, B., Xia, Y., & Xu, P. (2022) · Physiological Research · doi:10.33549/physiolres.934908 · Cited by 2 · see citing works

Clusterin secretion is attenuated by pro-inflammatory cytokines in culture models of cartilage degradationPreprint

Matta, C., Fellows, C. R., Quasnichka, H. L., Williams, A., Jeremiasse, B., Allaway, D., & Mobasheri, A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.05.078105 · Cited by 2 · see citing works

Trappin-2/Elafin and Clusterin serum levels in pemphigus vulgaris and correlation with the severity score

Aya, B. Y., Shehata, R. R., Alaa, A.-E. S., Amira, K. A., Fatma, A.-E. S., & Gomaa, A. S. (2021) · Egyptian Journal of Dermatology and Venerology · doi:10.4103/ejdv.ejdv_7_21 · Cited by 1 · see citing works

The genes behind rheumatology

Häupl, T., Grützkau, A., Stuhlmüller, B., Skriner, K., Burmester, G. R., & Radbruch, A. (2008) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8334-3_13 · Cited by 1 · see citing works

Transcriptomic analysis reveals distinct molecular signatures and regulatory networks of osteoarthritic chondrocytes versus mesenchymal stem cells during chondrogenesis

Lin, T.-Y., Mishra, V. K., Dubey, R., Chaturvedi, T. P., Narayan, S. A., Fang, H.-W., Tsai, L.-W., & Dubey, N. K. (2025) · Biomedical Papers · doi:10.5507/bp.2025.008 · Cited by 1 · see citing works

Clusterin (CLU) and its interacting proteins in cell signalling and neuroblastoma

Chaiwatanasirikul, K. (2012) · UCL Discovery (University College London)

The Role of Diet, Erythrocyte Membrane Fatty Acid Composition, and Alzheimer's-related Genes in Systemic Inflammation in the Cache County Memory Study

Jalloun, R. A. (2021) · Digital Commons - USU (Utah State University) · doi:10.26076/4558-0376

Neuroblastoma: Role of Clusterin as a Tumor Suppressor Gene

Sala, A., & Chaiwatanasirikul, K. (2011) · Pediatric cancer · doi:10.1007/978-94-007-2418-1_16

Longitudinal blood based biomarkers of Alzheimer's disease pathology in healthy elderly individuals

Westwood, S. (2014)

Biomarkers of Anterior Cruciate Ligament Injury and Recovery

Chng, Y. L. (2019) · Queensland University of Technology · doi:10.5204/thesis.eprints.134198

Clusterin, a potential pathophysiological actor in rheumatoid arthritis

Devauchelle‐Pensec, V., Bréban, M., Dougados, M., Fournier, C., & Chiocchia, G. (2004) · Arthritis Research · doi:10.1186/ar1404 · Cited by 1 · see citing works

The role of clusterin in the pathophysiology of selected rheumatic diseases

Kropáčková, T. (2025) · Digital Repository (National Repository of Grey Literature)

Implication of clusterin in TNF-α response of rheumatoid synovitis: lesson from in vitro knock-down of clusterin in human synovial fibroblast cells

Falgarone, G., Essabbani, A., Dumont, F., Cagnard, N., Mistou, S., & Chiocchia, G. (2011) · Physiological Genomics · doi:10.1152/physiolgenomics.00095.2010 · Cited by 8 · see citing works

Clusterin exacerbates interleukin-1β-induced inflammation via suppressing PI3K/Akt pathway in human fibroblast-like synoviocytes of knee osteoarthritis

Ungsudechachai, T., Honsawek, S., Jittikoon, J., & Udomsinprasert, W. (2022) · Scientific Reports · doi:10.1038/s41598-022-14295-7 · Cited by 17 · see citing works

Exploring the translational potential of clusterin as a biomarker of early osteoarthritis

Kalvaityte, U., Matta, C., Bernotienė, E., Pushparaj, P. N., Kiapour, A. M., & Mobasheri, A. (2021) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2021.10.001 · Cited by 24 · see citing works