The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guérin Infection
Open accessAbstract
IL-17 is a cytokine that induces neutrophil-mediated inflammation, but its role in protective immunity against intracellular bacterial infection remains unclear. In the present study, we demonstrate that IL-17 is an important cytokine not only in the early neutrophil-mediated inflammatory response, but also in T cell-mediated IFN-γ production and granuloma formation in response to pulmonary infection by Mycobacterium bovis bacille Calmette-Guérin (BCG). IL-17 expression in the BCG-infected lung was detected from the first day after infection and the expression depended on IL-23. Our observations indicated that γδ T cells are a primary source of IL-17. Lung-infiltrating T cells of IL-17-deficient mice produced less IFN-γ in comparison to those from wild-type mice 4 wk after BCG infection. Impaired granuloma formation was also observed in the infected lungs of IL-17-deficient mice, which is consistent with the decreased delayed-type hypersensitivity response of the infected mice against mycobacterial Ag. These data suggest that IL-17 is an important cytokine in the induction of optimal Th1 response and protective immunity against mycobacterial infection.
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Cites
Cua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
Murphy, C. A., Langrish, C. L., Chen, Y., Blumenschein, W., McClanahan, T., Kastelein, R. A., Sedgwick, J. D., & Cua, D. J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030896 · Cited by 1,669
T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J. J., Garrone, P., Garcia, E., Saeland, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2593 · Cited by 1,526 · cited 1×
“It has been reported that IL-17 is produced by TCR CD4 CD8 thymocytes (54) as well as by activated CD4 and CD4 CD45RO memory T cells (9).”
BackgroundRequirement of Interleukin‐17A for Systemic Anti– Candida albicans Host Defense in Mice
Huang, W., Na, L., Fidel, P. L., & Schwarzenberger, P. (2004) · The Journal of Infectious Diseases · doi:10.1086/422329 · Cited by 859
Microbial lipopeptides induce the production of IL-17 in Th cells
Infante-Duarte, C., Horton, H. F., Byrne, M. C., & Kamradt, T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6107 · Cited by 586 · cited 1×
“This finding is consistent with a report showing that exogenously added IL-17 affected neither Th1/Th2 phenotype differentiation nor IL-17 production (62).”
ResultAntonysamy, M. A., Fanslow, W. C., Fu, F., Li, W., Qian, S., Troutt, A. B., & Thomson, A. W. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.1.577 · Cited by 293
Cited by
Cell-Mediated Immune Responses in Tuberculosis
Cooper, A. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132703 · Cited by 1,162
Martin, B., Hirota, K., Cua, D. J., Stockinger, B., & Veldhoen, M. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.020 · Cited by 822
Saijo, S., Ikeda, S., Yamabe, K., Kakuta, S., Ishigame, H., Akitsu, A., Fujikado, N., Kusaka, T., Kubo, S., Chung, S.-H., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.001 · Cited by 733
Self-citationJetten, A. M. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07003 · Cited by 673
Ribot, J. C., deBarros, A., Pang, D. J., Neves, J. F., Peperzak, V., Roberts, S. J., Girardi, M., Borst, J., Hayday, A. C., Pennington, D. J., et al. (2009) · Nature Immunology · doi:10.1038/ni.1717 · Cited by 628
Metadata
- Authors
- Umemura, M., Yahagi, A., Hamada, S., Begum, M. D., Watanabe, H., Kawakami, K., Suda, T., Sudo, K., Nakae, S., Iwakura, Y., & Matsuzaki, G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-03
- Volume
- 178
- Issue
- 6
- Pages
- 3786-3796
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1553227656
- Cited by
- 519
- References
- 6
- FWCI
- 29.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guérin Infection. https://app.cochat.ai/papers/10.4049/jimmunol.178.6.3786
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- Umemura, M., Yahagi, A., Hamada, S., Begum, M. D., Watanabe, H., Kawakami, K., Suda, T., Sudo, K., Nakae, S., Iwakura, Y., & Matsuzaki, G. (2007). IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guérin Infection. The Journal of Immunology. https://doi.org/10.4049/jimmunol.178.6.3786
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
