Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

Martin, Bruno; Hirota, Keiji; Cua, Daniel J.; Stockinger, Brigitta; Veldhoen, Marc

doi:10.1016/j.immuni.2009.06.020

Cited by 822Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

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Martin, Bruno, Hirota, Keiji, Cua, Daniel J., Stockinger, Brigitta, Veldhoen, Marc·2009·Immunity

DOI 10.1016/j.immuni.2009.06.020

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Abstract

Gammadelta T cells are an innate source of interleukin-17 (IL-17), preceding the development of the adaptive T helper 17 (Th17) cell response. Here we show that IL-17-producing T cell receptor gammadelta (TCRgammadelta) T cells share characteristic features with Th17 cells, such as expression of chemokine receptor 6 (CCR6), retinoid orphan receptor (RORgammat), aryl hydrocarbon receptor (AhR), and IL-23 receptor. AhR expression in gammadelta T cells was essential for the production of IL-22 but not for optimal IL-17 production. In contrast to Th17 cells, CCR6(+)IL-17-producing gammadelta T cells, but not other gammadelta T cells, express Toll-like receptors TLR1 and TLR2, as well as dectin-1, but not TLR4 and could directly interact with certain pathogens. This process was amplified by IL-23 and resulted in expansion, increased IL-17 production, and recruitment of neutrophils. Thus, innate receptor expression linked with IL-17 production characterizes TCRgammadelta T cells as an efficient first line of defense that can orchestrate an inflammatory response to pathogen-derived as well as environmental signals long before Th17 cells have sensed bacterial invasion.

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Expression of IL-22 requires AhR.
“it was demonstrated that expression of IL-22 requires the AhR (Martin et al., 2009; Veldhoen et al., 2008).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Martin et al., 2009

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Authors: Martin, B., Hirota, K., Cua, D. J., Stockinger, B., & Veldhoen, M.
Affiliations: National Institute for Medical Research (GB)
Corresponding author: Veldhoen, Marc
ORCID: Hirota, Keiji
Stockinger, Brigitta
Veldhoen, Marc
Venue: Immunity
Publisher: Elsevier BV
Published: 2009-08
Volume: 31
Issue: 2
Pages: 321-330
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2009.06.020
OpenAlex: W2014913358
Cited by: 822
References: 57
Citations by year: 2026: 12 · 2025: 16 · 2024: 27 · 2023: 29 · 2022: 36 · 2021: 32 · 2020: 33 · 2019: 27 · 2018: 41 · 2017: 54 · 2016: 48 · 2015: 53 · 2014: 68 · 2013: 80 · 2012: 86
FWCI: 38.18
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1446 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: γδ T cells, IL-17, Th17 cells, aryl hydrocarbon receptor, CCR6, RORγ, IL-23, IL-22, Toll-like receptors, Dectin-1, innate immunity, neutrophil recruitment, pathogen recognition, environmental cues, inflammation
MeSH terms: Interleukin-22, Dectin-1, Animals, Bacterial Infections, T-Lymphocytes, Helper-Inducer, Interleukins, Membrane Proteins, Mice, Inbred C57BL, Nerve Tissue Proteins, Neutrophils, Receptors, Thyroid Hormone, Interleukin-6, T-Lymphocyte Subsets, Receptors, Antigen, T-Cell, gamma-delta, Receptors, Retinoic Acid, Receptors, Aryl Hydrocarbon, Interleukin-17, Lectins, C-Type, Toll-Like Receptor 1, Toll-Like Receptor 2, Mice, Basic Helix-Loop-Helix Proteins, Interleukin-23, Receptors, CCR6, Nuclear Receptor Subfamily 1, Group F, Member 3

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Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

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