The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Unravelling the Complexity of T Cell Abnormalities in Common Variable Immunodeficiency
Abstract
We investigated several phenotypic and functional parameters of T cell-mediated immunity in a large series of common variable immunodeficiency (CVID) patients. We demonstrated that the vast majority of CVID patients presented multiple T cell abnormalities intimately related among them, the severity of which was reflected in a parallel loss of CD4+ naive T cells. A strong correlation between the number of CD4+ naive T cells and clinical features was observed, supporting the subgrouping of patients according to their number of naive CD4+ T lymphocytes. A reduced thymic output and disrupted CD4+ and CD8+ TCR repertoires paralleled the contraction of CD4+ naive T cell pools. The evaluation of activation markers and cytokine production indicated a strong T cell activation that was significantly related to the increased levels of T cell turnover and apoptosis. Finally, discrete genetic profiles could be demonstrated in groups of patients showing extremely diverse T cell subset composition and function. Naive CD4+ T cell levels were significantly associated with the switched memory B cell-based classification, although the concordance between the respective subgroups did not exceed 58.8%. In conclusion, our data highlight the key role played by the T cell compartment in the pathogenesis of CVID, pointing to the need to consider this aspect for classification of this disease.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Common Variable Immunodeficiency: Clinical and Immunological Features of 248 Patients
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Immunomodulation of Autoimmune and Inflammatory Diseases with Intravenous Immune Globulin
Kazatchkine, M. D., & Kaveri, S. V. (2001) · New England Journal of Medicine · doi:10.1056/nejmra993360 · Cited by 1,209
Diagnostic Criteria for Primary Immunodeficiencies
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Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency
Grimbacher, B., Hutloff, A., Schlesier, M., Glocker, E., Warnatz, K., Dräger, R., Eibel, H., Fischer, B., Schäffer, A. A., Mages, H. W., et al. (2003) · Nature Immunology · doi:10.1038/ni902 · Cited by 733
TACI is mutant in common variable immunodeficiency and IgA deficiency
Castigli, E., Wilson, S. A., Garibyan, L., Rachid, R., Bonilla, F., Schneider, L., & Geha, R. S. (2005) · Nature Genetics · doi:10.1038/ng1601 · Cited by 702
Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans
Salzer, U., Chapel, H. M., Webster, A. D. B., Pan-Hammarström, Q., Schmitt-Graeff, A., Schlesier, M., Peter, H. H., Rockstroh, J. K., Schneider, P., Schäffer, A. A., et al. (2005) · Nature Genetics · doi:10.1038/ng1600 · Cited by 673
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T Cell Dynamics in HIV-1 Infection
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Cited by
A Homozygous CARD9 Mutation in a Family with Susceptibility to Fungal Infections
Glocker, E.-O., Hennigs, A., Nabavi, M., Schäffer, A. A., Woellner, C., Salzer, U., Pfeifer, D., Veelken, H., Warnatz, K., Tahami, F., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810719 · Cited by 800
Varzaneh, F. N., Keller, B., Unger, S., Aghamohammadi, A., Warnatz, K., & Rezaei, N. (2014) · Journal of Clinical Immunology · doi:10.1007/s10875-014-0053-0 · Cited by 62
Metadata
- Authors
- Giovannetti, A., Pierdominici, M., Mazzetta, F., Marziali, M., Renzi, C., Mileo, A. M., De Felice, M., Mora, B., Esposito, A., Carello, R., Pizzuti, A., Paggi, M. G., Paganelli, R., Malorni, W., & Aiuti, F.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-03
- Volume
- 178
- Issue
- 6
- Pages
- 3932-3943
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1605796307
- Cited by
- 273
- References
- 42
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Giovannetti, A., Pierdominici, M., Mazzetta, F., Marziali, M., Renzi, C., Mileo, A. M., De Felice, M., Mora, B., Esposito, A., Carello, R., Pizzuti, A., Paggi, M. G., Paganelli, R., Malorni, W., & Aiuti, F. (2007). Unravelling the Complexity of T Cell Abnormalities in Common Variable Immunodeficiency. The Journal of Immunology. https://doi.org/10.4049/jimmunol.178.6.3932
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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