The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
T Cell Dynamics in HIV-1 Infection
Abstract
▪ Abstract In the absence of antiretroviral treatment, HIV-1 establishes a chronic, progressive infection of the human immune system that invariably, over the course of years, leads to its destruction and fatal immunodeficiency. Paradoxically, while viral replication is extensive throughout the course of infection, deterioration of conventional measures of immunity is slow, including the characteristic loss of CD4+T cells that is thought to play a key role in the development of immunodeficiency. This conundrum suggests that CD4+T cell–directed viral cytopathicity alone cannot explain the course of disease. Indeed, recent advances now indicate that HIV-1 pathogenesis is likely to result from a complex interplay between the virus and the immune system, particularly the mechanisms responsible for T cell homeostasis and regeneration. We review these data and present a model of HIV-1 pathogenesis in which the protracted loss of CD4+T cells results from early viral destruction of selected memory T cell populations, followed by a combination of profound increases in overall memory T cell turnover, damage to the thymus and other lymphoid tissues, and physiological limitations in peripheral CD4+T cell renewal.
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Cites
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Self-citationVisualizing the generation of memory CD4 T cells in the whole body
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HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function
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Cited by
Moore, J. P., Kitchen, S. G., Pugach, P., & Zack, J. A. (2004) · AIDS Research and Human Retroviruses · doi:10.1089/088922204322749567 · Cited by 494
CD8+ T cell efficacy in vaccination and disease
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Self-citationInduction of HIV-1 latency and reactivation in primary memory CD4+ T cells
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Peripheral Blood CCR4+CCR6+ and CXCR3+CCR6+ CD4+ T Cells Are Highly Permissive to HIV-1 Infection
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Metadata
- Authors
- Douek, D. C., Picker, L. J., & Koup, R. A.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2003-04
- Volume
- 21
- Issue
- 1
- Pages
- 265-304
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2159578627
- Cited by
- 571
- References
- 16
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- closed
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