The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
IL-10 Induces IL-10 in Primary Human Monocyte-Derived Macrophages via the Transcription Factor Stat3
Open accessAbstract
IL-10 is an important immunosuppressive cytokine that can down-regulate expression of other cytokines and has been shown to down-regulate itself. We show, in this study, that treatment of human monocyte-derived macrophages with IL-10 induces IL-10 mRNA in a dose- and time-dependent manner with an optimum induction at 100 ng/ml and at 6 h, whereas IL-10-induced IL-10 protein can be detected at 18 h. In the same cells, IL-10 can partially suppress IL-10 mRNA induced by LPS, but only down to the level of IL-10-induced IL-10. An adenoviral luciferase reporter construct driven by the −195 IL-10 promoter, which contains a Stat motif, was readily induced by both IL-10 and LPS. Mutation of this Stat motif ablated IL-10 activation of this promoter, but not the LPS activation. Finally, we show that overexpression of a dominant-negative Stat3 protein will prevent IL-10 induction, but not LPS induction, of IL-10 mRNA. These data show that IL-10 induces IL-10 in monocyte-derived macrophages in an autocrine manner via activation of the transcription factor Stat3.
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The role of STATs in transcriptional control and their impact on cellular function
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STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-α3
Liu, L., McBride, K. M., & Reich, N. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501643102 · Cited by 348
IL-10 Gene Expression Is Controlled by the Transcription Factors Sp1 and Sp3
Tone, M., Powell, M. J., Tone, Y., Thompson, S. A. J., & Waldmann, H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.286 · Cited by 250
Role of Stat3 in Lipopolysaccharide-Induced IL-10 Gene Expression
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The STAT3 isoforms α and β have unique and specific functions
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The regulation of IL-10 production by immune cells
Saraiva, M., & O'Garra, A. (2010) · Nature Reviews Immunology · doi:10.1038/nri2711 · Cited by 3,164
Interleukin‐10: new perspectives on an old cytokine
Mosser, D. M., & Zhang, X. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00706.x · Cited by 1,077
Cytokine Signaling Modules in Inflammatory Responses
O'Shea, J. J., & Murray, P. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.002 · Cited by 818
Awasthi, A., Carrier, Y., Peron, J. P. S., Bettelli, E., Kamanaka, M., Flavell, R. A., Kuchroo, V. K., Oukka, M., & Weiner, H. L. (2007) · Nature Immunology · doi:10.1038/ni1541 · Cited by 804
Zheng, L., Kelly, C. J., Battista, K. D., Schaefer, R., Lanis, J. M., Alexeev, E. E., Wang, R. X., Onyiah, J. C., Kominsky, D. J., & Colgan, S. P. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700105 · Cited by 549
Metadata
- Authors
- Staples, K. J., Smallie, T., Williams, L. M., Foey, A., Burke, B., Foxwell, B. M. J., & Ziegler-Heitbrock, L.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-04
- Volume
- 178
- Issue
- 8
- Pages
- 4779-4785
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1841338648
- Cited by
- 160
- References
- 7
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: IL-10 Induces IL-10 in Primary Human Monocyte-Derived Macrophages via the Transcription Factor Stat3. https://app.cochat.ai/papers/10.4049/jimmunol.178.8.4779
- The paper
- Staples, K. J., Smallie, T., Williams, L. M., Foey, A., Burke, B., Foxwell, B. M. J., & Ziegler-Heitbrock, L. (2007). IL-10 Induces IL-10 in Primary Human Monocyte-Derived Macrophages via the Transcription Factor Stat3. The Journal of Immunology. https://doi.org/10.4049/jimmunol.178.8.4779
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
