Role of Stat3 in Lipopolysaccharide-Induced IL-10 Gene Expression

Benkhart, Elke M; Siedlar, Maciej; Wedel, Angela; Werner, Thomas; Ziegler-Heitbrock, H W Loems

doi:10.4049/jimmunol.165.3.1612

Cited by 249Cytokine Signaling Pathways and InteractionsGenomics and Chromatin DynamicsNF-κB Signaling Pathways

Role of Stat3 in Lipopolysaccharide-Induced IL-10 Gene Expression

Benkhart, Elke M, Siedlar, Maciej, Wedel, Angela, Werner, Thomas, Ziegler-Heitbrock, H W Loems·2000·The Journal of Immunology

DOI 10.4049/jimmunol.165.3.1612

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Abstract

IL-10 is a unique cytokine because it is anti-inflammatory and immunosuppressive. IL-10 is regulated at the level of transcription, but the critical motifs and the relevant transcription factors controlling this gene have remained elusive to date. We now report that a sequence at −120 bp in the human IL-10 promoter binds Stat3 but no other Stat proteins. Mutation of this motif abrogates LPS-induced trans-activation. Overexpression of dominant negative Stat3 suppresses promoter activity, while wild-type Stat3 leads to an enhancement of this activity. Our results show that Stat3, by binding to a single motif in the IL-10 promoter, is controlling expression of the human IL-10 gene.

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Molecular mechanisms in down-regulation of IL-10 gene expression by IFN-gamma
Schaefer, A. E. (2005) · OpenGrey (Institut de l'Information Scientifique et Technique)

Authors: Benkhart, E. M., Siedlar, M., Wedel, A., Werner, T., & Ziegler-Heitbrock, H. W. L.
Affiliations: Institut für Immunologie (DE)
Instituto de Medicina Genómica (ES)
Institute for Immunology, University of Munich , Munich ,
Corresponding author: Siedlar, Maciej
Wedel, Angela
ORCID: Siedlar, Maciej
Werner, Thomas
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2000-08-01
Volume: 165
Issue: 3
Pages: 1612-1617
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.165.3.1612
OpenAlex: W1591670144
Cited by: 249
References: 24
Citations by year: 2026: 5 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 9 · 2013: 8 · 2012: 19
FWCI: 3.38
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Site cant be reached (submittedVersion)
Topics: Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: STAT3, IL-10, lipopolysaccharide, transcriptional regulation, promoter elements, dominant-negative STAT3, transcriptional activation, anti-inflammatory cytokines, transcription factors
MeSH terms: Cell Line, DNA-Binding Proteins, Gene Expression Regulation, Genetic Vectors, Humans, Lipopolysaccharides, Promoter Regions, Genetic, Structure-Activity Relationship, Transcription, Genetic, Transfection, Signal Transduction, Transcriptional Activation, Trans-Activators, Mutagenesis, Site-Directed, Interleukin-10, Sequence Deletion, STAT3 Transcription Factor

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Role of Stat3 in Lipopolysaccharide-Induced IL-10 Gene Expression

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