The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
NKT Cell Activation Mediates Neutrophil IFN-γ Production and Renal Ischemia-Reperfusion Injury
Open accessAbstract
Previous work has shown that ischemia-reperfusion (IR) injury (IRI) is dependent on CD4+ T cells from naive mice acting within 24 h. We hypothesize that NKT cells are key participants in the early innate response in IRI. Kidneys from C57BL/6 mice were subjected to IRI (0.5, 1, 3, and 24 h of reperfusion). After 30 min of reperfusion, we observed a significant increase in CD4+ cells (145% of control) from single-cell kidney suspensions as measured by flow cytometry. A significant fraction of CD4+ T cells expressed the activation marker, CD69+, and adhesion molecule, LFA-1high. Three hours after reperfusion, kidney IFN-γ-producing cells were comprised largely of GR-1+CD11b+ neutrophils, but also contained CD1d-restricted NKT cells. Kidney IRI in mice administered Abs to block CD1d, or deplete NKT cells or in mice deficient of NKT cells (Jα18−/−), was markedly attenuated. These effects were associated with a significant decrease in renal infiltration and, in activation of NKT cells, and a decrease in IFN-γ-producing neutrophils. The results support the essential role of NKT cells and neutrophils in the innate immune response of renal IRI by mediating neutrophil infiltration and production of IFN-γ.
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Cites
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
Human neutrophils produce interferon gamma upon stimulation by interleukin-12
Ethuin, F., Gérard, B., Benna, J. E., Boutten, A., Gougereot-Pocidalo, M.-A., Jacob, L., & Chollet-Martin, S. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700148 · Cited by 141
Cited by
Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
Gelderblom, M., Leypoldt, F., Steinbach, K., Behrens, D., Choe, C.-U., Siler, D. A., Arumugam, T. V., Orthey, E., Gerloff, C., Tolosa, E., et al. (2009) · Stroke · doi:10.1161/strokeaha.108.534503 · Cited by 1,066
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
Brennan, P. J., Brigl, M., & Brenner, M. B. (2013) · Nature Reviews Immunology · doi:10.1038/nri3369 · Cited by 835
Inflammation in Acute Kidney Injury
Kinsey, G. R., Li, L., & Okusa, M. D. (2008) · Nephron Experimental Nephrology · doi:10.1159/000142934 · Cited by 417
Self-citationLi, L., Huang, L., Sung, S.-S. J., Vergis, A. L., Rosin, D. L., Rose, C. E., Lobo, P. I., & Okusa, M. D. (2008) · Kidney International · doi:10.1038/ki.2008.500 · Cited by 393
Self-citationKIM-1–mediated phagocytosis reduces acute injury to the kidney
Yang, L., Brooks, C. R., Xiao, S., Sabbisetti, V., Yeung, M. Y., Hsiao, L.-L., Ichimura, T., Kuchroo, V., & Bonventre, J. V. (2015) · Journal of Clinical Investigation · doi:10.1172/jci75417 · Cited by 366
Metadata
- Authors
- Li, L., Huang, L., Sung, S.-S. J., Lobo, P. I., Brown, M. G., Gregg, R. K., Engelhard, V. H., & Okusa, M. D.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-05-01
- Volume
- 178
- Issue
- 9
- Pages
- 5899-5911
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1752304426
- Cited by
- 331
- References
- 2
- FWCI
- 14.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, L., Huang, L., Sung, S.-S. J., Lobo, P. I., Brown, M. G., Gregg, R. K., Engelhard, V. H., & Okusa, M. D. (2007). NKT Cell Activation Mediates Neutrophil IFN-γ Production and Renal Ischemia-Reperfusion Injury. The Journal of Immunology. https://doi.org/10.4049/jimmunol.178.9.5899
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