The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Inflammation in Acute Kidney Injury
Open accessAbstract
Ischemia-reperfusion injury (IRI) is one of the major causes of acute kidney injury (AKI) and evidence supporting the involvement of both innate and adaptive immunity in renal IRI has accumulated in recent years. In addition to leukocytes, kidney endothelial cells promote inflammation after IRI by increasing adhesion molecule expression and vascular permeability. Kidney tubular epithelial cells increase complement binding and upregulate toll-like receptors, both of which lead to cytokine/chemokine production in IRI. Activation of kidney resident dendritic cells, interferon-γ-producing neutrophils, infiltrating macrophages, CD4+ T cells, B cells and invariant natural killer T cells are all implicated in the pathogenesis of AKI. The complex interplay between innate and adaptive immunity in renal IRI is still not completely understood, but major advances have been made. This review summarizes these recent advances to further our understanding of the immune mechanisms of acute kidney injury.
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Self-citationInjury of the renal microvascular endothelium alters barrier function after ischemia
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Cited by
Mechanisms and therapeutic targets of ischemic acute kidney injury
Han, S. J., & Lee, H. T. (2019) · Kidney Research and Clinical Practice · doi:10.23876/j.krcp.19.062 · Cited by 258
Hepcidin Mitigates Renal Ischemia-Reperfusion Injury by Modulating Systemic Iron Homeostasis
Scindia, Y., Dey, P., Thirunagari, A., Liping, H., Rosin, D. L., Floris, M., Okusa, M. D., & Swaminathan, S. (2015) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014101037 · Cited by 141
Self-citationThe aging kidney: increased susceptibility to nephrotoxicity
Wang, X., Bonventre, J., & Parrish, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150915358 · Cited by 132
Ibrahim, Y. F., Moussa, R. A., Bayoumi, A. M. A., & Ahmed, A.-S. F. (2020) · Inflammopharmacology · doi:10.1007/s10787-019-00628-y · Cited by 75
Vormann, M. K., Tool, L. M., Ohbuchi, M., Gijzen, L., van Vught, R., Hankemeier, T., Kiyonaga, F., Kawabe, T., Goto, T., Fujimori, A., et al. (2022) · Kidney360 · doi:10.34067/kid.0003622021 · Cited by 39
Metadata
- Authors
- Kinsey, G. R., Li, L., & Okusa, M. D.
- Venue
- Nephron Experimental Nephrology
- Publisher
- S. Karger AG
- Published
- 2008-09-18
- Volume
- 109
- Issue
- 4
- Pages
- e102-e107
- ISSN
- 1660-2129 (ISSN-L)
- OpenAlex
- W2162724808
- Cited by
- 417
- References
- 23
- FWCI
- 17.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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