Cited by 187Cytokine Signaling Pathways and InteractionsNF-κB Signaling PathwaysT-cell and B-cell Immunology

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Cutting Edge: A Transcriptional Repressor and Corepressor Induced by the STAT3-Regulated Anti-Inflammatory Signaling Pathway

El Kasmi, Karim C, Smith, Amber M, Williams, Lynn, Neale, Geoffrey, Panopolous, Athanasia, Watowich, Stephanie S, Häcker, Hans, Foxwell, Brian M J, Murray, Peter J·2007·The Journal of Immunology

DOI 10.4049/jimmunol.179.11.7215

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Abstract

IL-10 regulates anti-inflammatory signaling via the activation of STAT3, which in turn controls the induction of a gene expression program whose products execute inhibitory effects on proinflammatory mediator production. In this study we show that IL-10 induces the expression of an ETS family transcriptional repressor, ETV3, and a helicase family corepressor, Strawberry notch homologue 2 (SBNO2), in mouse and human macrophages. IL-10-mediated induction of ETV3 and SBNO2 expression was dependent upon both STAT3 and a stimulus through the TLR pathway. We also observed that ETV3 expression was strongly induced by the STAT3 pathway regulated by IL-10 but not by STAT3 signaling activated by IL-6, which cannot activate the anti-inflammatory signaling pathway. ETV3 and SBNO2 repressed NF-kappaB- but not IFN regulatory factor 7 (IRF7)-activated transcriptional reporters. Collectively our data suggest that ETV3 and SBNO2 are components of the pathways that contribute to the downstream anti-inflammatory effects of IL-10.

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Long, P., Wang, Q., Zhang, Y., Zhu, X., Yu, K., Jiang, H., Liu, X., Zhou, M., Yuan, Y., Liu, K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13647178
Additional file 1 of Functional screen of inflammatory bowel disease genes reveals key epithelial functions
Ntunzwenimana, J. C., Boucher, G., Paquette, J., Gosselin, H., Alikashani, A., Morin, N., Beauchamp, C., Thauvette, L., Rivard, M.-È., Dupuis, F., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16986877
Additional file 3 of Functional screen of inflammatory bowel disease genes reveals key epithelial functions
Ntunzwenimana, J. C., Boucher, G., Paquette, J., Gosselin, H., Alikashani, A., Morin, N., Beauchamp, C., Thauvette, L., Rivard, M.-È., Dupuis, F., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16986883
Additional file 4 of Functional screen of inflammatory bowel disease genes reveals key epithelial functions
Ntunzwenimana, J. C., Boucher, G., Paquette, J., Gosselin, H., Alikashani, A., Morin, N., Beauchamp, C., Thauvette, L., Rivard, M.-È., Dupuis, F., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16986886
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Li, M.-H., & Salehian-Dehkordi, H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-43994-0.00017-4
Additional file 1 of A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer
Mayoh, C., Gifford, A. J., Terry, R. L., Lau, L. M. S., Wong, M., Rao, P., Shai-Hee, T., Saletta, F., Khuong-Quang, D.-A., Qin, V. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22625752
Additional file 1 of Reconstructing the ancestral gene pool to uncover the origins and genetic links of Hmong–Mien speakers
Gao, Y., Zhang, X., Chen, H., Lu, Y., Ma, S., Yang, Y., Zhang, M., & Xu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26692618
Additional file 1 of Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome
Long, P., Wang, Q., Zhang, Y., Zhu, X., Yu, K., Jiang, H., Liu, X., Zhou, M., Yuan, Y., Liu, K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13647169
Additional file 2 of Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome
Long, P., Wang, Q., Zhang, Y., Zhu, X., Yu, K., Jiang, H., Liu, X., Zhou, M., Yuan, Y., Liu, K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13647172
Additional file 2 of Reconstructing the ancestral gene pool to uncover the origins and genetic links of Hmong–Mien speakers
Gao, Y., Zhang, X., Chen, H., Lu, Y., Ma, S., Yang, Y., Zhang, M., & Xu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26692621
Additional file 3 of Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome
Long, P., Wang, Q., Zhang, Y., Zhu, X., Yu, K., Jiang, H., Liu, X., Zhou, M., Yuan, Y., Liu, K., et al. (2021) · Figshare · doi:10.6084/m9.figshare.13647175
Additional file 2 of Functional screen of inflammatory bowel disease genes reveals key epithelial functions
Ntunzwenimana, J. C., Boucher, G., Paquette, J., Gosselin, H., Alikashani, A., Morin, N., Beauchamp, C., Thauvette, L., Rivard, M.-È., Dupuis, F., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16986880
Caractérisation phénotypique des anomalies de développement et d'homéostasie du lignage mélanocytaire de deux lignées de souris transgéniques
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Studies on allergic diseases and B cells in the past 20 years: a bibliometric analysis via CiteSpace and VOSviewer
Mai, W., Chen, X., Ye, W., Zhang, G., & 梁文瑜 (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1760388
The Convergence of Tumor-Specific Promoters and Nanodelivery Systems in Precision Cancer Gene Therapy
Han, X., Ping, Y., Xu, Y., Zhu, Y., Teng, X., & Du, S. (2026) · SynBio · doi:10.3390/synbio4020010

Authors: El Kasmi, K. C., Smith, A. M., Williams, L., Neale, G., Panopolous, A., Watowich, S. S., Häcker, H., Foxwell, B. M. J., & Murray, P. J.
Affiliations: Department of Infectious Diseases, St. Jude Children’s Research Hospital , Memphis, TN 38105
St. Jude Children's Research Hospital (US)
Imperial College London (GB)
The University of Texas MD Anderson Cancer Center (US)
ORCID: Smith, Amber M
Williams, Lynn
Neale, Geoffrey
Watowich, Stephanie S
Murray, Peter J
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 2007-12-01
Volume: 179
Issue: 11
Pages: 7215-7219
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.179.11.7215
OpenAlex: W2127303484
Cited by: 182
References: 30
Citations by year: 2026: 5 · 2025: 10 · 2024: 13 · 2023: 15 · 2022: 9 · 2021: 15 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 5 · 2016: 8 · 2015: 10 · 2014: 6 · 2013: 11 · 2012: 14
FWCI: 4.89
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (T32CA009598, P 30CA 21765, P30CA021765, T32 CA09598-16)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: IL-10, STAT3 signaling, transcriptional repressor, corepressors, anti-inflammatory signaling, macrophages, NF-κB, IRF7, interleukin-6
MeSH terms: Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Line, Gene Expression Regulation, Humans, Macrophages, Mice, Inbred C57BL, Repressor Proteins, RNA, Messenger, Time Factors, Transcription Factors, Signal Transduction, Interleukin-10, Mice, Knockout, RNA, Small Interfering, Proto-Oncogene Proteins c-ets, STAT3 Transcription Factor, Mice

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Cutting Edge: A Transcriptional Repressor and Corepressor Induced by the STAT3-Regulated Anti-Inflammatory Signaling Pathway

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