The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
An IL-17F/A Heterodimer Protein Is Produced by Mouse Th17 Cells and Induces Airway Neutrophil Recruitment
Abstract
IL-17A and IL-17F are related homodimeric proteins of the IL-17 family produced by Th17 cells. In this study, we show that mouse Th17 cells also produce an IL-17F/A heterodimeric protein. Whereas naive CD4+ T cells differentiating toward the Th17 cell lineage expressed IL-17F/A in higher amounts than IL-17A/A homodimer and in lower amounts than IL-17F/F homodimer, differentiated Th17 cells expressed IL-17F/A in higher amounts than either homodimer. In vitro, IL-17F/A was more potent than IL-17F/F and less potent than IL-17A/A in regulating CXCL1 expression. Neutralization of IL-17F/A with an IL-17A-specific Ab, and not with an IL-17F-specific Ab, reduced the majority of IL-17F/A-induced CXCL1 expression. To study these cytokines in vivo, we established a Th17 cell adoptive transfer model characterized by increased neutrophilia in the airways. An IL-17A-specific Ab completely prevented Th17 cell-induced neutrophilia and CXCL5 expression, whereas Abs specific for IL-17F or IL-22, a cytokine also produced by Th17 cells, had no effects. Direct administration of mouse IL-17A/A or IL-17F/A, and not IL-17F/F or IL-22, into the airways significantly increased neutrophil and chemokine expression. Taken together, our data elucidate the regulation of IL-17F/A heterodimer expression by Th17 cells and demonstrate an in vivo function for this cytokine in airway neutrophilia.
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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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Transforming growth factor-β induces development of the TH17 lineage
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Interleukin-17 Family Members and Inflammation
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Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
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Cited by
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Functional Specialization of Interleukin-17 Family Members
Iwakura, Y., Ishigame, H., Saijo, S., & Nakae, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.02.012 · Cited by 1,289
Late Developmental Plasticity in the T Helper 17 Lineage
Lee, Y. K., Turner, H., Maynard, C. L., Oliver, J. R., Chen, D., Elson, C. O., & Weaver, C. T. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.005 · Cited by 1,053
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Self-citationThe roles of IL‐17A in inflammatory immune responses and host defense against pathogens
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Metadata
- Authors
- Liang, S. C., Long, A. J., Bennett, F., Whitters, M. J., Karim, R., Collins, M., Goldman, S. J., Dunussi-Joannopoulos, K., Williams, C. M. M., Wright, J. F., & Fouser, L. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-12-01
- Volume
- 179
- Issue
- 11
- Pages
- 7791-7799
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2134728320
- Cited by
- 371
- References
- 41
- FWCI
- 11.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: An IL-17F/A Heterodimer Protein Is Produced by Mouse Th17 Cells and Induces Airway Neutrophil Recruitment. https://app.cochat.ai/papers/10.4049/jimmunol.179.11.7791
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- Liang, S. C., Long, A. J., Bennett, F., Whitters, M. J., Karim, R., Collins, M., Goldman, S. J., Dunussi-Joannopoulos, K., Williams, C. M. M., Wright, J. F., & Fouser, L. A. (2007). An IL-17F/A Heterodimer Protein Is Produced by Mouse Th17 Cells and Induces Airway Neutrophil Recruitment. The Journal of Immunology. https://doi.org/10.4049/jimmunol.179.11.7791
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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