TLR9 Contributes to Antiviral Immunity during Gammaherpesvirus Infection
Open accessAbstract
The human gammaherpesviruses Kaposi’s sarcoma-associated herpesvirus and EBV cause important infections. As pathogenetic studies of the human infections are restricted, murine gammaherpesvirus 68 serves as a model to study gammaherpesvirus pathogenesis. TLRs are a conserved family of receptors detecting microbial molecular patterns. Among the TLRs, TLR9 recognizes unmethylated CpG DNA motifs present in bacterial and viral DNA. The aim of this study was to assess the role of TLR9 in gammaherpesvirus pathogenesis. Upon stimulation with murine gammaherpesvirus 68, Flt3L-cultured bone marrow cells (dendritic cells) from TLR9−/− mice secreted reduced levels of IL-12, IFN-α, and IL-6, when compared with dendritic cells from wild-type mice. Intranasal infection of TLR9−/− and wild-type mice did not reveal any differences during lytic and latent infection. In contrast, when infected i.p., TLR9−/− mice showed markedly higher viral loads both during lytic and latent infection. Thus, we show for the first time that TLR9 is involved in gammaherpesvirus pathogenesis and contributes to organ-specific immunity.
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EBV is the most commonly implicated virus in the development of HLH in humans and is a DNA virus that triggers TLR9.
“The most commonly implicated virus in the development of HLH in humans is EBV, a DNA virus that triggers TLR9 (32).”
From Repeated TLR9 stimulation results in macrophage activation syndrome–like disease in mice (2011) · cites this paper as [32]
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Saghafian‐Hedengren, S. (2009)
- Authors
- Guggemoos, S., Hangel, D., Hamm, S., Heit, A., Bauer, S., & Adler, H.
- Affiliations
- Helmholtz Munich (DE)
- Technical University of Munich (DE)
- Philipps University of Marburg (DE)
- Corresponding author
- Guggemoos, Simone
- Adler, Heiko
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-01-01
- Volume
- 180
- Issue
- 1
- Pages
- 438-443
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1496860963
- Cited by
- 83
- References
- 55
- Citations by year
- 2026: 1 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 9 · 2014: 9 · 2013: 5 · 2012: 7
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Keywords
- TLR9, gammaherpesvirus infection, murine gammaherpesvirus 68, Kaposi's sarcoma-associated herpesvirus, Epstein-Barr virus, antiviral immunity, dendritic cells, CpG DNA, IL-12, interferon-alpha, interleukin-6, viral load, organ-specific immunity, TLR9-deficient mice
- MeSH terms
- Animals, Dendritic Cells, Herpesviridae Infections, Humans, Mice, Mutant Strains, Interleukin-6, Interferon-alpha, Gammaherpesvirinae, Interleukin-12, Toll-Like Receptor 9, Mice
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